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    A new candidate for wound dressing materials: s-IPN hydrogel-based highly elastic and pH-sensitive drug delivery system containing pectin and vinyl phosphonic acid
    (Pergamon-Elsevier Science Ltd, 2024) Seref, Elif; Ilgin, Pinar; Özay, Özgür; Ozay, Hava
    In this study, we developed pH-sensitive semi-interpenetrating network (s-IPN) hydrogels, composed of pectin, 2hydroxyethyl methacrylate (HEMA), and vinyl phosphonic acid (VPA) using N,N'-methylene bis(acrylamide) (MBA) as a cross-linker with the free-radical polymerization method. The formation of s-IPNs was confirmed by FTIR studies. SEM images showed the addition of VPA to the polymeric matrix of s-IPN hydrogels formed additional microporous structures within the hydrogel network. The s-IPN hydrogel had perfect mechanical features like stretchability, compressibility and elasticity. Additionally, the swelling behavior of s-IPN hydrogels in deionized water and solutions with diverse pH was assessed. To research use as a controlled drug delivery material, the hydrogel was loaded with cimetidine and trimethoprim. At pH 7.2, the in vitro drug release profile was observed and nearly 60 % of the drugs were released from s-IPN hydrogel within 10 h. Additionally, the most appropriate kinetic release model was Higuchi, followed by Korsmeyer-Peppas. Finally, silver sulfadiazine (SSD) was added to s-IPN hydrogel for use as a smart wound dressing material. Antimicrobial analysis of the SSDloaded s-IPN hydrogel found it had antimicrobial features, inducing 15, 17 and 23 mm inhibition zones against Staphylococcus aureus (gram-positive), Escherichia coli (gram -negative) and Candida albicans (fungus) microorganisms, respectively. In light of the obtained results, based on being easily shapable with appropriate mechanical and physical features, pectin/p(HEMA-co-VPA) and pectin/p(HEMA-co-VPA)@SSD s-IPN hydrogels are potential candidates for use as controlled drug delivery and wound dressing materials in the biomedical field.
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    Green synthesized silver nanoparticles based on N-3-(dimethylamino)propyl methacrylamide/2-hydroxyethyl methacrylate hydrogels for antibacterial wound dressing material
    (Taylor & Francis Inc, 2024) Seref, Elif; Özay, Özgür
    In this study, hydrogels were synthesized using Prunus persica ev. Bayrami & ccedil; Beyaz & imath; extract as a crosslinker. N-3-(Dimethylamino)propyl methacrylamide (DMAPMA) and 2-Hydroxyethyl methacrylate (HEMA) monomers were used in hydrogels synthesized by redox polymerization. Hydrogel@Ag composites were created by synthesizing Ag-0 nanoparticles within hydrogel network structures cross-linked with plant extract using an in-situ green synthesis method. These hydrogels and composites were characterized by swelling, FTIR, TEM, XRD, TGA methods. The synthesized hydrogels and hydrogel@Ag composites were loaded with Naproxen and Cefazolin drugs. The in-vitro drug release profiles of the hydrogels were examined in a pH = 5.5 and PBS environment, and it was determined that approximately 75% of the drugs were released within 5 h. The release kinetics model for the hydrogels was the Higuchi model, followed by the Korsmeyer-Peppas model. Ag-0 nanoparticle encapsulation significantly affected the degree of swelling. The hydrogel cross-linked with MBA showed a swelling capacity of 370.16% by mass, while the hydrogel cross-linked with fruit extract exhibited a swelling capacity of 1000.78% by mass. The silver-encapsulated hydrogel demonstrated an even higher swelling capacity of 2313% by mass. Additionally, antibacterial tests against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis microorganisms, showed that Ag-free hydrogels did not exhibit antibacterial activity. [GRAPHICS] .
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    Öğe
    Rapid preparation of Ru(0) nanoparticles stabilized with water-soluble biopolymer for hydrogen production from ammonia borane: Development of battery-like hydrolysis media
    (Pergamon-Elsevier Science Ltd, 2023) Seref, Elif; Tercan, Melek; Ozay, Hava; Ilgin, Pinar; Özay, Özgür
    The biohybrid Na-Alg@Ru catalyst was prepared as a result of stabilizing Ru(0) nano particles with biopolymer chains of sodium alginate. The in-situ prepared Ru(0) nano particles had an average particle size of 1.023 & PLUSMN; 0.097 nm. The monodisperse Ru(0) nanoparticles prepared with a very practical, inexpensive and rapid method were used as a catalyst in hydrogen production by the hydrolysis reaction of ammonia borane (AB). The Na-Alg@Ru catalyst containing 3 mg Ru(0) metal catalyzed the hydrolysis of 50 mM AB with 100% yield, and the activation energy (Ea) of the reaction was estimated as 61.05 kJ mol-1. In addition, the Na-Alg@Ru nanoparticles were prepared with acrylamide as p(AAm)/NaAlg@Ru hydrogel films suitable for use in hydrogen production in fuel cells, which represents a battery-like environment, and used for hydrogen production from AB. Thus, it was shown that the catalysts prepared in a few nm size could easily be used in battery-like environments.& COPY; 2023 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.