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    Assessment of ADAM17 and ADAM10 proteins with CXCL10 and thyroid autoimmunity in vitiligo pathogenesis
    (Termedia Publishing House Ltd, 2022) Kilic, Sevilay; Sehitoglu, Hilal; Gul, Ceren
    Introduction: Vitiligo is an acquired chronic pigmentation disorder. The etiopathogenesis is still not fully understood. Aim: To research the correlation of ADAM proteins, shown to be associated with autoimmune diseases like rheumatoid arthritis and lupus erythematosus, with vitiligo also considered to be an autoimmune disease. Material and methods: The study included a patient group of 45 patients with the diagnosis of vitiligo and a control group of 45 healthy adults. The ADAM10 and ADAM17 protein serum levels and CXCL10 and thyroid autoantibody anti-TG and anti-TPO levels along with FT3, FT4, and TSH hormone levels were determined with the ELISA method. Statistical analysis of results was made with the SPSS 22.0 program. Results: In vitiligo patients, the ADAM10 levels (2.34 +/- 0.80 pg/ml) were statistically significantly low compared to the control group (10.29 +/- 1.71 pg/ml) (p < 0.05), while the ADAM17 levels (128.51 +/- 14.37 pg/ml) were statistically significantly high compared to the control group (16.30 +/- 6.31 pg/ml) (p < 0.05). Additionally, the CXCL10 levels were observed to be statistically significantly higher in the patient group (275.11 +/- 62.36) than in the control group (107.08 +/- 33.12). Thyroid autoimmunity test results (anti-TG, anti-TPO, and TSH) were shown to be different to a statistically significant degree in the patient group compared to the control group (p < 0.001, p < 0.000, p = 0.003, respectively). Statistical analyses used the Kolmogorov-Smirnov, Mann-Whitney U test, and the independent T-test. Conclusions: We obtained data that are important in terms of understanding the pathogenesis. ADAM10 and ADAM17 proteins may be new targets for future therapeutic approaches.
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    Protective Effect of Possible Olive Oil, Olive Leaves and Olive Seeds on Ethanol Induced Experimental Ulcer Model in Rats
    (Wiley-Blackwell, 2015) Vural, Zehra; Kahraman, Mustafa; Sehitoglu, Hilal; Vural, Ahmet; Arik, Kasim; Simsek, Tuncer; Cetiner, Sule
    [Anstract Not Available]
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    The Effect of Oleuropein on the Treatment of Allergic Rhinitis
    (Georg Thieme Verlag Kg, 2025) Cil, Ozge Caglar; Buyuk, Basak; Eroglu, Huseyin Avni; Sehitoglu, Hilal
    Introduction Allergic rhinitis is a disease that negatively affects social and work life and sometimes does not respond to many treatments. Therefore, new treatments are needed. For the prevention and treatment of allergies, oleuropein has been emphasized, and positive results have been shown in the literature. Objective To investigate the effects of general and topical oleuropein during the allergic rhinitis period and the histopathological changes in the nasal mucosa compared with steroid nasal sprays and control group in rats. Methods We developed an experimental animal model with 44 rats divided into 6 groups. Except for the control group, the allergic rhinitis in the other five groups was created with ovalbumin. As treatment, saline was administered to group 3, steroids, to group 4, oleuropein, to group 5, and steroids and oleuropein were administered to group 6. The effects of the drugs were examined histopathologically and the levels of immunoglobulin E (IgE) in the blood were compared. Results Considering the symptomatic findings in rats, we could observe that allergic rhinitis occurred. Based on the IgE levels and histopathological findings, we have statistically shown that oleuropein may be effective in treatment of allergy rhinitis. Conclusion Oleuropein has been shown to be useful in the treatment of allergic rhinitis in an animal model, but further studies are needed before it is introduced into the medical practice.