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    Antioxidant Activity of Syringic Acid Prevents Oxidative Stress in L-arginine-Induced Acute Pancreatitis: An Experimental Study on Rats
    (Int College Of Surgeons, 2015) Cikman, Oztekin; Soylemez, Omer; Ozkan, Omer Faruk; Kiraz, Hasan Ali; Sayar, Ilyas; Ademoglu, Serkan; Taysi, Seyithan
    The aim of this study was to investigate the possible protective role of antioxidant treatment with syringic acid (SA) on L-arginine-induced acute pancreatitis (AP) using biochemical and histopathologic approaches. A total of 30 rats were divided into 3 groups. The control group received normal saline intraperitoneally. The AP group was induced by 3.2 g/kg body weight L-arginine intraperitoneally, administered twice with an interval of 1 hour between administrations. The AP plus SA group, after having AP induced by 3.2 g/kg body weight L-arginine, was given SA (50 mg kg(-1)) in 2 parts within 24 hours. The rats were killed, and pancreatic tissue was removed and used in biochemical and histopathologic examinations. Compared with the control group, the mean pancreatic tissue total oxidant status level, oxidative stress index, and lipid hydroperoxide levels were significantly increased in the AP group, being 30.97 +/- 7.13 (P < 0.05), 1.76 +/- 0.34 (P < 0.0001), and 19.18 +/- 4.91 (P < 0.01), respectively. However, mean total antioxidant status and sulfhydryl group levels were significantly decreased in the AP group compared with the control group, being 1.765 +/- 0.21 (P < 0.0001) and 0.21 +/- 0.04 (P < 0.0001), respectively. SA reduces oxidative stress markers and has antioxidant effects. It also augments antioxidant capacity in L-arginine-induced acute toxicity of pancreas in rats.
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    Öğe
    Determination of the prognostic importance of ostrogen and progesteron receptors on gastric cancer
    (2013) Çikman, Öztekin; Söylemez, Ömer; Sayar, Ilyas; Karaayvaz, Muammer
    Presently, gastric cancers solution to early diagnose and resection is surgery. In local-regional-advanced stage (Stage 3A and especially stage 3B) cases, it's quite difficult to decide absolute indication of surgery. In our study, we aimed to show the importance of the prognosis by investigating the presence of ostrogen and progesteron receptors and their effects on the survival of stage 3A and 3B gastric cancers patiens. The survivability rates of 20 cases with Stage 3A and 3B gastric cancer have been analyzed. In the course of our clinical research we prepared the cancerous and the normal tissue samples in paraphine blocks with immunohistochemical methods and analyzed under photomicroscope ER and PR were evaluated being based on the stain of breast cancers. Of the 20 patients 2 (10%) of them were observed to have had ER possitive 5 (25%) of them PR possitive and 2 (10%) of them were observed to had both ER and PR possitive. Of the 16 patients who were in Stage 3B 7 of them produced receptor possitive results both in proximal and distal tumours (in proximal tumours, 1 case was ER possitive 1 PR possitive; in distal tumours 1 case was ER possitive 4 cases were PR possitive). Life expectancy in these cases who produced receptor possitive results was determined to be approximately 3 years. Although the same surgical procedures are applied to all of the cases the increase in life expectancy in those cases with possitive receptors brings to mind that prognosis would also be better in such cases. we found in the course of our study that the life expectancy was remarkably higher in those cases of Stage 3B, that are ER and/or PR possitive. Therefore we are of the conviction that such procedures as total gastrectomy and DII dissection would be beneficial in increasing the survivability in such cases.