Yazar "Sanati, Mehdi" seçeneğine göre listele

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  • Küçük Resim
    Öğe
    A novel approach to glioblastoma multiforme treatment using modulation of key pathways by naturally occurring small molecules
    (Springer Basel Ag, 2025) Afshari, Amir R.; Sanati, Mehdi; Aminyavari, Samaneh; Keshavarzi, Zakieh; Ahmadi, Seyed Sajad; Oroojalian, Fatemeh; Karav, Sercan
    Glioblastoma multiforme (GBM), the fatal primary brain malignancy in adults, represents significant health challenges, and its eradication has been the ultimate goal of numerous medical investigations. GBM therapy encompasses various interventions, e.g., chemotherapy by synthetic cytotoxic agents like temozolomide (TMZ), radiotherapy, and, more recently, immunotherapy. A notable focus has been on incorporating naturally occurring substances in treating malignancies. Polyphenols and terpenoids, widely present in fruits and vegetables, constitute primary categories of agents employed for this purpose. They pose direct and indirect impacts on tumor growth and chemoresistance, mainly through impacting the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling, crucial in cellular processes, metabolism, and programmed death. This paper thoroughly discusses the biologic effects and practical application of polyphenols and terpenoids on GBM through the PI3K/Akt/mTOR signaling in vitro and in vivo.
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    Öğe
    Repurposing ivermectin: a new hope for glioblastoma multiforme?
    (Springer Birkhauser, 2025) Mohtashami, Elmira; Bibak, Bahram; Sanati, Mehdi; Afshari, Sadaf; Kahkhaie, Kolsoum Rezaie; Vahedi, Mohammad Mahdi; Jalili-Nik, Mohammad
    Ivermectin is the most extensively researched macrocyclic lactone due to its potential anticancer and antiparasitic use. Nonetheless, there are more compounds within this family, including doramectin and abamectin. In the current era of medicinal repurposing, ivermectin has received renewed focus following its initial development for the treatment of parasitic conditions such as scabies, elephantiasis, and river blindness. Recent studies indicate that ivermectin may inhibit the proliferation of specific tumor cells by regulating many signaling pathways implicated in cancer progression. Despite the growing body of research on the topic, critical issues about its anticancer processes remain unresolved. Our study focused on ivermectin, its mechanisms of action, and its potential uses against glioblastoma multiforme (GBM).