Yazar "Sahin, Mustafa" seçeneğine göre listele

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    Öğe
    Multi-Partied Quantum Digital Signature Scheme Without Assumptions On Quantum Channel Security
    (Iop Publishing Ltd, 2016) Sahin, Mustafa; Yilmaz, Ihsan
    In this study, we generalized quantum digital signature scheme for three-partied[5] to the multi-partied. Also we analyzed this scheme for repudiation, forgery and colluding adversaries.
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    Öğe
    Temporal Variation of Biochemical Markers and Adenoma Predictors in Normocalcemic Primary Hyperparathyroidism: A Multicenter Retrospective Analysis
    (Wiley, 2025) Aycicek, Bercem; Tuna, Mazhar Muslum; Engin, Ismail; Sahin, Mustafa; Zuhur, Sayid; Gulcelik, Nese Ersoz; Yagci, Huseyin
    Objective: This study aimed to evaluate the diagnostic performance of biochemical markers in normocalcemic primary hyperparathyroidism (nPHPT), analyse their temporal variations, and assess their correlation with adenoma localisation and size. Methods: In this multicenter retrospective study-the largest patient cohort reported in the literature to date (n = 474) we comprehensively profiled normocalcemic patients diagnosed with primary hyperparathyroidism nPHPT was diagnosed based on persistently elevated PTH levels with normal serum calcium after excluding secondary causes such as vitamin D deficiency, renal impairment, and other conditions. This retrospective multicenter study included a large cohort of patients whose biochemical markers-including serum calcium, phosphorus, magnesium, vitamin D, parathyroid hormone (PTH), and glomerular filtration rate (GFR)-were measured at three time points, using standardised laboratory protocols. Although in routine clinical practice these measurements are typically performed at regular intervals of 3-6 months, resulting in approximately three assessments during an 18-month follow-up period. Urinary calcium and creatinine levels were also determined, and imaging modalities (ultrasonography, sestamibi scintigraphy, and computed tomography) were employed for adenoma detection. Statistical analyses comprised repeated measures ANOVA, logistic regression, correlation analysis, and ROC analysis, performed using Jamovi software. Results: Serial evaluations revealed significant temporal changes in key biochemical parameters, including a significant decline in serum calcium and PTH levels alongside a significant increase in urinary calcium excretion. Logistic regression analysis identified higher PTH levels, higher corrected calcium, and larger adenoma size as independent predictors of adenoma localisation, while ROC analysis confirmed that PTH exhibited the highest diagnostic accuracy (AUC = 0.91, 95% CI: 0.84-0.95, p < 0.001). Conclusion: The large scale of our patient cohort reinforces the robustness of our statistical analyses and provides comprehensive insight into the dynamic nature of nPHPT.
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    Öğe
    The Antibody Response to Endoplasmic Reticulum Stress in Hashimoto's Thyroiditis
    (Galenos Yayincilik, 2013) Asik, Mehmet; Sahin, Mustafa; Anaforoglu, Inan; Arikan, Serap; Haydardedeoglu, Filiz Eksi; Ertugrul, Taner Derun; Tutuncu, Neslihan Bascil
    Purpose: We aimed to investigate the presence of antibodies (Anti-BIP) against binding immunoglobulin protein (BIP), an endoplasmic reticulum (ER) chaperone with immune modulator and anti-apoptotic effects in Hashimoto's thyroiditis (HT) patients. Material and Method: We included sixty-two autoimmune thyroiditis patients, 20 with euthyroid autoimmune thyroiditis, 27 with subclinical hypothyroidism and 15 with hypothyroid, and a control group of 37 healthy subjects. Results: No statistically significant difference was determined in anti-BIP levels among the HT subgroups or in comparison with the control group (p= 0.889). Discussion: Although BIP activation has been shown in vitro in thyroid cells, no difference was determined in our study in anti-BIP levels between the HT patient subgroups and the control group. This suggests that antibodies developing against BIP through apoptosis and/or T cell response are either not related to HT or at levels that cannot be determined by measuring serum.