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Öğe Comparison of effects of classic LMA, cobraPLA and V-gel rabbit on QTc interval(Comenius Univ, 2015) Toman, H.; Erbas, M.; Kiraz, H. A.; Sahin, H.; Ovali, M. A.; Uzun, M.AIM: We aimed to compare the effects of three different supraglottic airway devices, the classic LMA, PLA, and V-gel, on hemodynamics and QTc in rabbits under general anesthesia. METHOD: The rabbits were divided into four groups: Group C (n = 5) control group with no airway device used, Group L (n = 5, classic LMA), Group P (n = 5, CobraPLA) and Group V (n = 5, V-gel-rabbit). Basal values of heart rate (HR), mean arterial pressure (MAP) and ECG for QTc interval were measured and the measurements were evaluated at 1, 5, 15, and 30 minutes after inserting the airway device RESULTS: The values of HR, MAP and QTc in Group V at minutes 1 and 5 were significantly different to those in Group L and Group P (p < 0.05). DISCUSSION: The classic-LMA and cobraPLA cover a wide part of the perilaryngeal area with cuffs inflated to about 60 cmH(2)O of pressure resulting in mucosal compression. As V-gel rabbit does not have a cuff, it covers a smaller part of the laryngopharyngeal area, and thus does not cause mucosal compression, and the hemodynamic response is weaker. CONCLUSION: When comparing hemodynamic responses to other supraglottic airway devices, the response to V-gel rabbit is minimal and we consider that similar studies using the I-gel on humans are required (Fig. 5, Ref. 31).Öğe Effects of tenoxicam in experimental corrosive esophagitis model(Oxford Univ Press Inc, 2015) Erbas, M.; Kiraz, H. A.; Kucuk, A.; Topaloglu, N.; Erdem, H.; Sahin, H.; Toman, H.Esophageal stricture, one of the important complications of corrosive esophagus, develops following edema and granulation tissue that forms during and after the inflammatory reactions. Tenoxicam, a non-steroid anti-inflammatory drug with a long half-life, prevents various leukocyte functions including phagocyte and histamine secretion by inhibiting prostaglandin synthesis and removes various oxygen radicals in the region of inflammation. We designed this as a histopathological study using tenoxicam in rats for which we created a corrosive esophagus model. After necessary authorizations were obtained, the study was performed in Canakkale 18 Mart University experimental animal laboratory. Twenty-four Wistar albino rats, weighing 220-240g, were used for the experiment. Experimental animals were randomized into three groups: tenoxicam group (group T, n:8), control group (group C, n:8), and sham group (group S, n:8). Tenoxicam 0.5mg/kg/day was administered to animals in group T, where esophageal burn was developed experimentally, 5mg/kg 0.9% NaCL was administered i.p. to rats in group C for 15 days, once in 24 hours. No procedure was applied to rats in group S. After 15 days, all animals were sacrificed under general anesthesia and their esophagi were extracted. As a result of histopathological evaluation, inflammation and fibroblast proliferation was not observed in rats in the sham group (group S). Intense inflammation was observed in six rats (6+/2-) in the control group, and fibroblast proliferation was observed as 5+/3-. And in treatment groups, inflammation was evaluated as 3+/5-, and fibroblast proliferation as 3+/5-. In our study, histopathologic damage score was higher in the control group (P < 0.005). We deduce that tenoxicam can be useful in the treatment of caustic esophageal injuries in the acute phase, but think that these drugs require further researches and clinical studies before routine clinical use.Öğe Investigation of the effects of oleuropein rich diet on rat enteric bacterial flora(Comenius Univ, 2016) Kiraz, A.; Simsek, T.; Tekin, S. Z.; Elmas, S.; Tekin, M.; Sahin, H.; Altinisik, H. B.OBJECTIVES AND BACKGROUND: Oleuropein is a phenolic compound of olive leaves. Enteric bacterial flora is very important for human health and diet is a directly affecting factor of enteric bacterial flora composition. In this study, it was hypothesized that oleuropein could reduce total aerobic bacterial count in rat caecal flora. METHODS: Twenty adult, male, Wistar albino rats were randomly divided into two groups. Group C (n=10) was fed with standard rat chow and water for 30 days. Group 0 (n=10) received olive leaf extract 20 mg/kg/day by intragastric gavage in addition to standard rat chow and water for 30 days. One gram of caecal content was collected from each rat and then consecutive 10-fold serial dilutions were prepared with a final concentration of 10(-8). Then 0.1 ml of each dilution were spread onto the surfaces of Plate Count Agar and Violet Red Bile Glucose Agar to enumerate the aerobic enteric bacteria. RESULTS: Total aerobic bacterial counts of Group 0 were significantly lower than of Group C in all agar plates inoculated with ceacal samples for every dilution (p<0.05). CONCLUSION: Adding oleuropein to enteral feeding solutions of critically ill patients may be adventageous in the presence of clinical conditions predisposing to bacterial translocation by reducing enteric bacterial counts (Tab. 1, Ref. 32). Text in PDF www.elis.sk.Öğe THE EFFECT OF OLEUROPEIN RICH DIET ON QTC INTERVAL IN ANESTHETIZED RABBITS(Lippincott Williams & Wilkins, 2016) Simsek, T.; Sahin, H.; Altinisik, H. B.; Altinisik, U.; Toman, H.; Kiraz, H. A.; Demiraran, Y.[Anstract Not Available]Öğe The impact of second-generation antipsychotics on psychosocial functioning in bipolar disorder(Elsevier Science Bv, 2014) Aydemir, O.; Cetinay-Aydin, P.; Gulec-Oyeckin, D.; Gulseren, S.; Putgul-Koybasi, G.; Sahin, H.[Anstract Not Available]
