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Öğe Alterations in sexual functions during and after pregnancy: Prejudice? Or Real?(Klinik Psikiyatri Dergisi, 2018) Beyazit, Fatma; Pek, Eren; Sahin, BasakSexual function in women is a complex and dynamic interaction of multiple variables including physical, emotinal, social, and physiological states. Moreover, sexual function is a key part of each human being's personality and a cornerstone in the overall couple relationship with an obvious affect on health related quality of life. A dysfunction in female sexual cycle can result in lack of desire for sexual contact, arousal and an inability to have an orgasm. Pregnancy is a period with many alterations in human physiology leading to challenges in sexual function. Endocrine, biologic, psychosomatic and social factors as well as anatomical alteations during pregnancy and the different mode of delivery may aggravate female sexual dysfunction. This literature review examines research articles that investigated female sexual function, sexual dysfunction, and sexual functioning in pregnancy in order to obtain how these parameters affect a woman's sexual related quality of life.Öğe An assessment of marital adjustment in patients with rheumatoid arthritis(Medical Association of Zenica-Doboj Canton, 2017) Resorlu, Hatice; Sahin, Basak; Ertekin, Hulya; Bilim, Serhad; Savas, YılmazAim To investigate marital adjustment in patients with rheumatoid arthritis and factors affecting this. Methods A total of 32 patients diagnosed with Steinbrocker class 1-2 rheumatoid arthritis and 32 healthy individuals from a similar age group were included. Sociodemographic characteristics, the Beck Depression Inventory (BDI), short–form 36(SF-36) and the dyadic adjustment scale (DAS) were evaluated in both groups. A visual analogue scale (VAS), the disease activity score 28 (DAS28) and a health assessment questionnaire (HAQ) were also investigated in the patient group. Results Mean ages were 46.5±9.2 years in the patient group and 47.7±8.1 in the control group (p=0.5). No significant difference was determined between the two groups in terms of sociodemographic characteristics. No statistically significant correlation was observed between erythrocyte sedimentation rate (ESR), patient and physician global VAS, DAS28, HAQ and morning stiffness and DAS total score. Comparison of DAS subunits revealed a significant difference in dyadic satisfaction and affectional expression in the patient and control groups (p=0.046 and p=0.037). A statistically significant negative correlation was observed between duration of the disease and marital adjustment (p=0.01;r= -0.58). Conclusion Due to its progressive and prolonged course rheumatoid arthritis can also affect individuals’ social relationships besides restricted daily living activities. Activation of rheumatoid arthritis did not affect marital adjustment in this study, but adjustment decreased with duration of the disease. © 2017, Medical Association of Zenica-Doboj Canton. All rights reserved.Öğe An Evaluation of Sexual Functions and Marital Adjustment in Female Patients with Fibromyalgia Syndrome(Galenos Yayincilik, 2019) Doner, Davut; Resorlu, Hatice; Zateri, Coskun; Sahin, Basak; Ertekin, Hulya; Oymak, SibelObjective: The purpose of this study was to investigate sexual functions and marital adjustment which are neglected issue in married female patients diagnosed with Fibromyalgia syndrome (FMS) and to reveal the factors affecting these. Materials and Methods: Sexually active, 47 married females who diagnosed with FMS and 50 healthy volunteers in a similar age group were included in the study. Beck anxiety inventory, beck depression inventory, female sexual function index (FSFI) and dyadic adjustment scale (DAS) evaluations were also performed for both groups. In the patient group, the severity of pain was evaluated by the visual analogue scale and functional impairment due to the disease was assessed by the fibromyalgia impact questionnaire (FIQ). Results: No significant difference was determined between the two groups in terms of socio-demographic features. FSFI and DAS total scores were significantly lower in the patient group compared to the controls (p<0.001, p=0.028, respectively). Low DAS scores were determined in patients with low FSFI scores (p=0.003, r=+0.043). Neither FSFI nor DAS scores have exhibited correlation with duration of disease and FIQ scores. Depression was correlated with both FSFI and DAS (p<0.001, r=-0.569; p<0.001, r=-0.546, respectively). Conclusion: In this study, sexual functions and marital adjustment were adversely affected in patients with FMS. This effect was found closely related to depression. However, there was no relationship determined between duration of the disease, the severity of pain and the functional impact.Öğe Chitinase-3-like protein 1 levels in bipolar disorder(Saudi Med J, 2019) Sahin, Basak; Inanli, Ikbal; Caliskan, Ali M.; Uysal, SemaObjectives: To evaluate the relationship between the expression level and biologic role of YKL-40 in bipolar disorder (BD). Methods: This case-control study was conducted in the Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey in 2015. One hundred and four patients diagnosed as having bipolar disorder (DSM5 criteria), and 96 participants were included as healthy controls in this study. A human YKL-40 enzyme-linked immunosorbent assay (ELISA) kit was used to measure the serum YKL-40 levels. As independent variables, we collected data on C-reactive protein (CRP), demographic variables, and medications. Results: The mean YLK-40 levels for the BD was 2723.5 +/- 543.8 pg/ml and control groups was 2132.5 +/- 576.3 pg/ml (t=7.42, p<0.001). The mean CRP levels for the BD was 0.4 +/- 0.6 mg/dl and control groups was 0.4 +/- 0.7 mg/dl (t=0.02, p=0.985). The receiver operating characteristics (ROC) analysis revealed an area under the curve (AUC) of YKL-40 in the diagnosis of BD as 0.79 (95% confidence interval [CI]: 0.72-0.85) with a sensitivity of 82.7% and specificity of 68.1% at a cutoff level of 2307.1 pg/ml. The use of antidepressants, antipsychotics, mood modifiers, and the presence of any comorbidity was not related to the YKL-40 levels (p> 0.05). Conclusion: With acceptable sensitivity and specificity levels, the YKL-40 can be utilized as a marker in the diagnosis and follow-up of BD.Öğe Clozapine and Aripiprazole-Induced Stuttering: A Case Report of Turner Syndrome with Schizophrenia(Kure Iletisim Grubu A S, 2016) Ertekin, Hulya; Ertekin, Yusuf Haydar; Sahin, Basak; Yayla, Sinan; Turkyilmaz, Ersin; Kara, MedineTurner Syndrome (TS) is the most common chromosomal anomaly in women. Its psychiatric manifestations have not been clearly defined. Occurrence of schizophrenia is higher in patients with TS than in the normal population. The literature has reported instances associating stuttering as a side effect of antipsychotic drugs, particularly clozapine-induced stuttering. We found only one case report describing aripiprazole-associated stuttering. In the present case report, we present a female patient with TS-diagnosed schizophrenia who had been treated with aripiprazole because she developed stuttering during treatment with clozapine and then developed dose-dependent stuttering with aripiprazole.Öğe Determining the factors influencing the intimate relationship between sexual satisfaction and dyadic adjustment in postmenopausal women(Termedia Publishing House Ltd, 2018) Beyazit, Fatma; Sahin, BasakIntroduction: Identifying and characterizing sexual dysfunction is crucial in order to improve the quality of the marital relationship in postmenopausal women. Regarding this, the present study aimed to determine the association of menopausal characteristics with sexual satisfaction and marital adjustment. Material and methods: This cross-sectional study was conducted on 89 postmenopausal women chosen using an improbable randomized sampling method. A questionnaire that collects demographic characteristics, the Dyadic Adjustment Scale (DAS) and The Golombok Rust Inventory of Sexual Satisfaction (GRISS) index were used to collect relevant data during the survey. Results: The mean age of postmenopausal women recruited to the present study was 54.6 +/- 6.7. The overall mean GRISS score and DAS score were 5.6 +/- 1.7 and 92.1 +/- 11.2 respectively. The mean GRISS scores were found to significantly increase as the ages of the women increased (p = 0.044). Mean DAS scores were lower in postmenopausal women that have menopause duration longer than 10 years (p = 0.035). Higher education level of the spouse is associated with lower GRISS scores (p = 0.024). No correlation was observed between marital adjustment and sexual satisfaction. Conclusions: Although sexual satisfaction and marital adjustment levels are decreased in the postmenopausal period, these two parameters do not seem to be related to each other. Multidimensional factors must be taken into account when evaluating sexual and marital satisfaction in postmenopausal women.Öğe Effect of Nausea and Vomiting on Anxiety and Depression Levels in Early Pregnancy(Ataturk Univ, 2018) Beyazit, Fatma; Sahin, BasakObjective: Nausea and vomiting of pregnancy (NVP) have been reported to be associated with distinct physiological responses to psychosocial stress. In this study, we aimed to evaluate the impact of nausea and vomiting on anxiety and depression during pregnancy. Materials and Methods: Eighty-three pregnant women with nausea and vomiting and 83 healthy pregnant women were included. All participants completed the demography- and pregnancy-related questionnaire, including Rhodes Index of Nausea and Vomiting, Beck Anxiety Inventory (BAI), and Edinburgh Postnatal Depression Scale (EPDS). Results: The median BAI and EPDS levels were 13 (min-max: 0-43) and 7 (min-max: 0-20) for the study group and 4 (min-max: 0-26) and 4 (min-max: 0-16) for control group, respectively. A univariate analysis revealed a statistically significant increase in terms of BAI levels (p<0.001) between the groups, but no significant difference was observed in terms of EPDS. In a logistic regression analysis, both anxiety (p=0.018) and depression (p=0.022) were found to be affected by NVP The BAI levels of the NVP group correlated with the severity of NVP. Conclusion: According to the results of the present study, women with severe NVP experienced a higher level of anxiety and depression which necessitates an extra awareness from healthcare professionals in order to be able to contribute effectively.Öğe Herbal remedies for perceived inadequate milk supply are perhaps not as safe as women think: A brief case report(Elsevier Science Bv, 2016) Sahin, Basak; Kaymaz, Nazan; Yildirim, Sule[Anstract Not Available]Öğe Increased Pathological Worry Levels in Patients with Alopecia Areata(Derman Medical Publ, 2017) Sahin, Basak; Soydas, Esra Akyol; Oguz, Sevilay; Isik, Selda; Ertekin, HulyaAim: Alopecia Areata (AA) is a type of hair loss that has been considered to have associations with various psychiatric disorders. In this study, we aimed to compare pathological worry levels between patients with AA and healthy controls (HC). Material and Method: Sixty-three patients with AA and 90 HCs were included in the present study after applying inclusion and exclusion criteria. The socio-demographic characteristics, some clinical characteristics, and the scores from the Penn State Worry Questionnaire (PSWQ) were compared between groups. Results: The demographic characteristics were found to be similar between groups except for gender. The family history of AA was significantly higher in the AA group. The mean score of PSWQ in the AA group was 44.02 +/- 11.59, compared to 39.71 +/- 7.77 in the HC group. The mean score of PSWQ was significantly higher in the AA group (t=-3.27, p= 0.001). Discussion: The present study is the first to compare pathological worry between patients with AA and HCs. We suggest that pathological worry should be more thoroughly investigated in patients with AA to improve their quality of life. Also, this can be an effective approach to targeting the patients who may develop anxiety disorder.Öğe Increased serum G72 protein levels in patients with schizophrenia: a potential candidate biomarker(Cambridge Univ Press, 2017) Akyol, Esra Soydas; Albayrak, Yakup; Aksoy, Nurkan; Sahin, Basak; Beyazyuz, Murat; Kuloglu, Murat; Hashimoto, KenjiObjective: The product of the G72 gene is an activator of d-amino acid oxidase and has been suggested to play a role in the pathogenesis of schizophrenia. Increased G72 protein levels may be associated with disturbed glutamatergic transmission and increased reactive oxygen species. Only one pilot study by Lin et al. has investigated the potential role of serum G72 protein levels as a biomarker for schizophrenia. In this study, we aimed to compare serum G72 protein levels between patients with schizophrenia and healthy controls, and to retest the results of the previous pilot study. Materials and methods: In total, 107 patients with a diagnosis of schizophrenia according to the inclusion and exclusion criteria and 60 age-sex-matched healthy controls were included in the study. The groups were compared regarding serum G72 protein levels. Results: The mean serum G72 protein values were 495.90 +/- 152.03 pg/ml in the schizophrenia group and 346.10 +/- 102.08 pg/ml in the healthy control group. The mean serum G72 protein level was significantly increased in the schizophrenia group compared with the healthy control group (t=-3.89, p<0.001). A receiver operating characteristics analysis was performed to compare the schizophrenia and healthy control groups. It was determined that the cut-off value was 141.51 pg/ml with a sensitivity of 0.991 and a specificity of 0.821. Conclusion: We suggest that serum G72 protein levels may represent a candidate biomarker for schizophrenia and have confirmed the results of the previous preliminary study. Additional studies with larger sample sizes and the inclusion of first episode schizophrenia patients are required to clarify the reliability and validity of serum G72 protein levels as a biomarker for schizophrenia.Öğe Metabolic syndrome and vaspin in patients with bipolar disorder(Elsevier Taiwan, 2018) Ertekin, Hulya; Sahin, Basak; Caliskan, Ali Metehan; Inanli, Ikbal; Ertekin, Yusuf HaydarMetabolic disorders and abnormal levels of circulating adipokines have been reported in patients with bipolar disorder (BD). The aim of this study was to investigate the differences in the correlations of vaspin plasma levels and metabolic parameters between two groups: patients with BD and mentally healthy persons. We measured plasma levels of vaspin, metabolic parameters, and metabolic syndrome (MS) in 101 patients with BD and 90 healthy control (HC) subjects. Patients with BD were evaluated with the Young Mania Rating Scale (YMRS) to assess manic symptoms and the Hamilton Depression Scale (HDS) to assess depressive symptoms. The Global Assessment of Functioning (GAF) was used to evaluate the general functions of the patients. Body mass index (BMI), weight, waist circumference (WC), fasting glucose, and triglyceride levels of the study group were statistically higher than those of the healthy controls (p = 0.001, p < 0.001, p < 0.001, p = 0.027, and p = 0.001 respectively). Plasma levels of vaspin were 0.978 ng/ml in patients with BD and 0.292 in the HC group (p < 0.001). Our study revealed associations between metabolic parameters/metabolic syndrome and vaspin plasma concentrations in patients with BD. Vaspin can play a specific role in the pathogenesis of metabolic disorders in these subjects and can be a specific indicator substance in BD. Copyright (C) 2018, Kaohsiung Medical University. Published by Elsevier Taiwan LLC.Öğe Profile differences of medical doctors from three different hospitals in Turkey concerning burnout, job satisfaction, and depression(Klinik Psikiyatri Dergisi, 2019) Sahin, Basak; Musaoglu, Esra; Dogan, Bilge; Yildirim, Armagan; Arslan, Tayyibe; Sahin, HasanObjective: This study aimed to compare job satisfaction, burnout, and depression scores of medical doctors from different regions in Turkey. Method: A cross-sectional study was performed during October 2013 in three cities from Turkey. Participants were asked to self-administer a demographic information questionnaire, the Minnesota Satisfaction Questionnaire (Internal work satisfaction-IWS and External work satisfaction-EWS), the Beck Depression Inventory (BDI), the Maslach Burnout Inventory (MBI), Maslach Emotional Exhaustion Score (MEES), and Maslach Personal Accomplishment Score (MPAS). Results: Mean (+/- SD) Total work satisfaction score was 66.2 +/- 12.6.118 participants had BDI scores of 10 or less while 40 participants had 11 or higher scores. Proportions for poor depersonalization, emotional exhaustion, and personal accomplishment were 18.6% (n=29), 5.8% (n=9), and 81.9% (n=127) respectively. There were significant differences concerning some variables between the three cities. Most of the doctors in Sirnak and Hakkari were younger, single, and less experienced compared to the more developed Canakkale (p<0.05). Discussion: In a hierarchical regression analysis, independent of the other factors, MPAS and MEES were predictors of the total job satisfaction score. MPAS and MEES are the most significant independent variables affecting job satisfaction. Decreasing stressors and assuring a motivating and supportive environment may prove to be helpful in the enhancement of job satisfaction.Öğe Psychiatric Disorders and Demographic Characteristics Among Geriatric Outpatients in Canakkale State Hospital(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2016) Ertekin, Hulya; Ertekin, Yusuf Haydar; Sahin, Basak; Kolat, Esra; Uludag, AysegulObjective: The elderly population in Turkey and in the world is progressively increasing and the increase is expected to be more prominent in the future. As the elderly population grows, there will be an increasing demand on health services, resulting in rapidly rising medical, psychiatric, and social healthcare problems. The aim of the present study is to determine the distribution of psychiatric illness, including gender-based differences, demographic characteristics and prevalence within all elderly age groups, among patients visiting the general psychiatry outpatient clinic. Method: This was a retrospective study using the data of the patient registry system for elderly patients who visited the general psychiatry outpatient clinic between September 2013 and February 2014. Patients were >= 65 years of age. Patients' demographic characteristics and their Axis I diagnoses according to DSM-IV-TR were recorded. Results: Of the 1044 patients who visited the general psychiatry outpatient clinic during the 6-month period, 15% (n=158) were aged >= 65 years; 62% of the 158 patients included in the study were female and 38% were male. Depression was present in 41% of patients; 21% had generalized anxiety disorder (GAD); 8% had adjustment disorder (AD), and 7% had schizophrenia. GAD was statistically significantly higher in females and AD was statistically significantly higher in males. Conclusion: Assessing demographic data including common diagnoses and diagnostic differences between genders in elderly patients is important to improve new diagnosis and treatment strategies.Öğe Quality of Life and Depression in Schizophrenia Patients Living in a Nursing Home(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2015) Ertekin, Hulya; Er, Mehmet; Ozayhan, Hatice Yardim; Yayla, Sinan; Akyol, Esra; Sahin, BasakObjective: Nursing homes are seen as alternative housing for patients with schizophrenia. However, it has not yet been established how suitable this accommodation is for schizophrenia patients. First aim of this study is to assess the quality of life and depression level in schizophrenic patients and compare this data with that of patients living with their families. Second aim is to assess factors related to the quality of living and depression state in all participants of this study. Method: This is a cross-sectional study conducted with patients presenting to the Psychotic Disorders Policlinic of the Beyhekim Psychiatric Clinic of Konya Training and Research Hospital consecutively between December 2012 and May 2013 who had received a diagnosis of schizophrenia according to DSM IV-TR. All participants were administered a sociodemographic data form, Brief Psychiatric Rating Scale (BPRS), Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), and Quality of Life Scale for Schizophrenia Patients (QLSSP). Results: CDSS scores were found to be significantly increased in schizophrenic patients living in nursing homes. Their QLSSP scores, including interpersonal relations, occupational role, mental symptoms, personal belongings/activity scores, and total scores were statistically significantly low. A significant negative correlation was observed between negative symptom levels and occupational area, mental findings, and the personal belongings/activity areas of quality of life. Between positive symptom levels and quality of life, only scores in the occupational area showed a significant negative correlation. A significant negative correlation between CSDS and QLS was observed in all areas. Conclusion: Quality of life and depression need to be evaluated in all schizophrenia patients, as they are conditions that significantly affect treatment and prognosis.
