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    Effect of high sound wave on ovarian tissue: an experimental study
    (Diagnosis Press, 2021) Kanbur, Savas; Sagir, Dilek
    After air pollution, the most important environmental factor threatening human health is noise. Physiologic damage or psychological damage can occur because of noise. Increased oxidative stress, vascular changes and mechanical trauma may be responsible for the physiologic damage mechanism of noise. This study aimed to reveal the effect of noise on follicles in ovaries. In the study, a total of 30 female Wistar albino rats (12 weeks old) were randomly divided into three groups (n = 10): the control group, no treatment; the sham group, exposed to stress conditions (but not to any high waves) in a special room at the same time as the high sound wave group; and the high sound wave (HSW) group, exposed to HSW in a special room for 28 days. At the end of the 28th day, the rats were sacrificed and ovarian tissues were harvested. Stereologic and biochemical analyses were performed. All stereologic volumetric parameters and Gonadal Somatic Index (GSI) values, lipid peroxidation (LPO) and glutathione (GSH) levels in all groups were evaluated statistically, and significant differences were found between the control and HSW, sham and HSW groups, respectively. However, no statistical difference was found between the control and sham groups. A decrease in catalase (CAT) and superoxide dismutase (SOD) activities were found in the HSW group compared with the control and sham groups, suggesting that noise can cause oxidative stress and damage to the ovaries.
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    Öğe
    Effects of supplementing the rainbow trout (Oncorhynchus mykiss) diet with Spirulina and Chlorella on the tissue's cadmium detoxification capacity, growth performance, fatty acid composition, antioxidant defense system and liver histology
    (Elsevier, 2025) Harmantepe, Fatma Burcu; Gundogdu, Ayse; Karsli, Zafer; Sagir, Dilek
    This study aimed to determine the effects of the addition of Spirulina and Chlorella of the diets of rainbow trout (Oncorhynchus mykiss) on their growth, nutrient composition, the parameters of their antioxidant defense systems, liver histology, and the cadmium removal process of their tissues. Fish with an average weight of 84.25 +/- 3.55 g containing Cd in their tissues were distributed in 15 tanks with 18 fish per tank. The fish were fed diets consisting of 0% (Control-1), 0% (Control-2), 4% Chlorella, 4% Spirulina and Chlorella +2% Spirulina twice a day until they were satiated for a period of 80 days. At the conclusion of the experiment, it was determined that diets containing microalgae demonstrated increased growth rates, and that the growth values obtained from the 4% Spirulina and the Control-1 were similar (p > 0.05). Regarding the fatty acid content, with the addition of microalgae to the diet, a significant (p < 0.05) decrease in SFA values and a significant (p < 0.05) increase in PUFA values were observed compared to the groups Control-1 and Control-2. On days 40 and 80, Cd levels in the muscle and liver tissue of the fish were found to be significantly (p < 0.05) lower in the groups that were fed diets containing microalgae in comparison with the Control-2 group. On days 40 and 80, the SOD, CAT, GSH, GST, and GPx values of liver tissues were higher (p < 0.05) than those of the Control-2 group. As a result of the semiquantitative histopathological evaluation of the liver tissues, improvements were observed in all groups containing microalgae; however, the most remarkable improvement was achieved in the Spirulina group. The results obtained in the study revealed that the addition of microalgae to rainbow trout feed removed Cd from liver and muscle tissues, reinforced the antioxidant defense system parameters, and increased growth. However, when the groups containing microalgae were compared among themselves, the diets containing 4 % Spirulina and 2 % Chlorella +2 % Spirulina were found to be more effective on these parameters.