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Öğe A Rare Association of Rheumatoid Arthritis with Crohn's Disease(Galenos Yayincilik, 2016) Resorlu, Hatice; Akbal, Erdem; Gokmen, Ferhat; Savas, Yilmaz[Anstract Not Available]Öğe A rare cause of low back pain: primary Ewing sarcoma of the lumbar spine(Elsevier Science Inc, 2016) Resorlu, Hatice; Aras, Adem B.; Zateri, Coskun; Goksel, Ferdi[Anstract Not Available]Öğe A rare cause of spinal dysraphism: lipomeningomyelocele(Elsevier Science Inc, 2016) Resorlu, Hatice; Gokmen, Ferhat; Resorlu, Mustafa; Akbal, Ayla; Bozkurt, Emre[Anstract Not Available]Öğe An assessment of marital adjustment in patients with rheumatoid arthritis(Medical Association of Zenica-Doboj Canton, 2017) Resorlu, Hatice; Sahin, Basak; Ertekin, Hulya; Bilim, Serhad; Savas, YılmazAim To investigate marital adjustment in patients with rheumatoid arthritis and factors affecting this. Methods A total of 32 patients diagnosed with Steinbrocker class 1-2 rheumatoid arthritis and 32 healthy individuals from a similar age group were included. Sociodemographic characteristics, the Beck Depression Inventory (BDI), short–form 36(SF-36) and the dyadic adjustment scale (DAS) were evaluated in both groups. A visual analogue scale (VAS), the disease activity score 28 (DAS28) and a health assessment questionnaire (HAQ) were also investigated in the patient group. Results Mean ages were 46.5±9.2 years in the patient group and 47.7±8.1 in the control group (p=0.5). No significant difference was determined between the two groups in terms of sociodemographic characteristics. No statistically significant correlation was observed between erythrocyte sedimentation rate (ESR), patient and physician global VAS, DAS28, HAQ and morning stiffness and DAS total score. Comparison of DAS subunits revealed a significant difference in dyadic satisfaction and affectional expression in the patient and control groups (p=0.046 and p=0.037). A statistically significant negative correlation was observed between duration of the disease and marital adjustment (p=0.01;r= -0.58). Conclusion Due to its progressive and prolonged course rheumatoid arthritis can also affect individuals’ social relationships besides restricted daily living activities. Activation of rheumatoid arthritis did not affect marital adjustment in this study, but adjustment decreased with duration of the disease. © 2017, Medical Association of Zenica-Doboj Canton. All rights reserved.Öğe An Evaluation of Provoked Vulvodynia, Pelvic Floor Muscles and Sexual Functions in Female Patients with Fibromyalgia Syndrome(Galenos Yayincilik, 2017) Resorlu, Hatice; Beyazit, Fatma; Doner, Davut; Oymak, Sibel; Zateri, CoskunObjective: The aim of our study is to investigate the genital origin of pain, particularly provoked vulvodynia (PVD) in female patients with Fibromyalgia syndrome (FMS), to reveal the relationship between PVD and pelvic floor muscle functions and to evaluate patients' sexual functions. Materials and Methods: Twenty four female patients who were diagnosed with FMS and who had not yet been treated, sexually active and 24 control cases were included to study. Severity of dyspareunia and dysmenorrhea was evaluated with a visual analogue scale, PVD was assessed using the cotton swab exam of vulva and sexual functions were evaluated with using the Female Sexual Function Index (FSFI). Additionally, pelvic floor muscles were graded using Brink scoring. Results: The severity means of menstrual term pain and dyspareunia severity were significantly higher in the patients than the control group (p=0.003, p=0.006). Significant differences were observed between the patient and control group in terms of vulvar pain in cotton swab exam and total Brink scores (both p<0.001). FSFI score was lower in the patient group than in the control group (p=0.001). A powerful correlation in the negative direction was determined between the result of cotton swab exam and Brink score (p<0.001, r=-0.575). Conclusion: The result of our study showed that dysmenorrhea, dyspareunia and PVD were significantly high in the FMS patients than in the control group. Pelvic floor muscle functions were affected in the FMS patients, and PVD was closely associated with the pelvic floor muscle functions.Öğe An Evaluation of Sexual Functions and Marital Adjustment in Female Patients with Fibromyalgia Syndrome(Galenos Yayincilik, 2019) Doner, Davut; Resorlu, Hatice; Zateri, Coskun; Sahin, Basak; Ertekin, Hulya; Oymak, SibelObjective: The purpose of this study was to investigate sexual functions and marital adjustment which are neglected issue in married female patients diagnosed with Fibromyalgia syndrome (FMS) and to reveal the factors affecting these. Materials and Methods: Sexually active, 47 married females who diagnosed with FMS and 50 healthy volunteers in a similar age group were included in the study. Beck anxiety inventory, beck depression inventory, female sexual function index (FSFI) and dyadic adjustment scale (DAS) evaluations were also performed for both groups. In the patient group, the severity of pain was evaluated by the visual analogue scale and functional impairment due to the disease was assessed by the fibromyalgia impact questionnaire (FIQ). Results: No significant difference was determined between the two groups in terms of socio-demographic features. FSFI and DAS total scores were significantly lower in the patient group compared to the controls (p<0.001, p=0.028, respectively). Low DAS scores were determined in patients with low FSFI scores (p=0.003, r=+0.043). Neither FSFI nor DAS scores have exhibited correlation with duration of disease and FIQ scores. Depression was correlated with both FSFI and DAS (p<0.001, r=-0.569; p<0.001, r=-0.546, respectively). Conclusion: In this study, sexual functions and marital adjustment were adversely affected in patients with FMS. This effect was found closely related to depression. However, there was no relationship determined between duration of the disease, the severity of pain and the functional impact.Öğe Association between apparent diffusion coefficient and intervertebral disc degeneration in patients with ankylosing spondylitis(E-Century Publishing Corp, 2015) Resorlu, Mustafa; Gokmen, Ferhat; Resorlu, Hatice; Adam, Gurhan; Akbal, Ayla; Cevizci, Sibel; Sariyildirim, AbdullahPurpose: To assess the relation between ankylosing spondylitis (AS) and degenerative disc disease emerging in association with various intrinsic and extrinsic factors and to evaluate the correlation between degree of degeneration in intervertebral discs and apparent diffusion coefficient (ADC) values. Methods: Thirty-five patients with AS and a control group of 35 patients were included in the study. Three hundred fifty intervertebral discs were assessed in terms of degeneration by analyzing signal intensities and morphologies on T2 weighted series of a 1.5 Tesla magnetic resonance scanner. ADC values were determined in diffusion weighted images (DWI) using a b value of 500 s/mm(2). Patients in the AS and control groups were compared in terms of intervertebral disc degeneration, and association between degree of degeneration and ADC values was analyzed. Results: The mean of total degeneration degrees for five lumbar intervertebral discs was significantly higher in the patients with AS compared to the control group (16.77 +/- 4.67 vs 13.00 +/- 4.08, respectively; P=0.001). When intervertebral discs were analyzed separately, disc degeneration was again significantly higher in patients with AS compared to the control group, with the exception of L5-S1. Age, cholesterol level, triglyceride level, duration of disease and BASFI index were significantly associated with degree of degeneration in patients with AS. A negative correlation was determined between disc degeneration and ADC value. Conclusion: AS is a risk factor for degenerative disc disease due to its systemic effects, the fact it leads to posture impairment and its inflammatory effects on the vertebrae. A decrease in ADC values is observed as degeneration worsens in degenerative disc disease.Öğe Association between mean platelet volume and bone mineral density in patients with ankylosing spondylitis and diagnostic value of diffusion-weighted magnetic resonance imaging(Soc Physical Therapy Science, 2015) Resorlu, Hatice; Resorlu, Mustafa; Gokmen, Ferhat; Akbal, Ayla; Adam, Gurhan; Komurcu, Erkam; Goksel, Ferdi[Purpose] The aim this study was to assess the relation between bone mineral density (BMD) and mean platelet volume (MPV) in ankylosing spondylitis (AS) patients, and evaluate the diagnostic role of the diffusion-weighted magnetic resonance imaging (MRI). [Subjects and Methods] Fifty patients diagnosed with AS were divided into two groups on the basis of BMD, a normal group (n=30) and an osteopenic (n=20) group. [Results] Duration of disease in the group with a normal BMD was 10.3 +/- 7.0 years, while it was 16.7 +/- 12.2 years in the osteopenia group. MPV was high in the osteopenia group, while no significant differences were observed between the groups in terms of apparent diffusion coefficient (ADC) and platelet distribution width (PDW). There was a positive correlation between MPV and duration of disease. Correlations between ADC value and the lumbar T score, femoral neck T score, and duration of disease were insignificant. A negative correlation was observed between BMD and disease duration. [Conclusion] Diffusion-weighted imaging provides valuable results in osteoporosis but is not a suitable technique for evaluating BMD in patients with AS because of the local and systemic inflammatory effects in the musculoskeletal system. The common pathophysiology of atherosclerosis and osteoporosis plays an important role in the negative correlation observed between MPV and BMD in patients with AS.Öğe Association between mean platelet volume and disease severity in patients with psoriasis and psoriatic arthritis(Termedia Publishing House Ltd, 2017) Kilic, Sevilay; Resorlu, Hatice; Isik, Selda; Oymak, Sibel; Akbal, Ayla; Hiz, Meliha Merve; Ogretmen, ZerrinIntroduction: Mean platelet volume (MPV) is an important marker that shows the activation and function of the platelets, which is effective in the inflammatory diseases. Aim: To show the relationship between MPV and the development of psoriatic arthritis (PA) in patients with psoriasis vulgaris (PV) and the correlation between MPV and psoriasis severity score (PASI). Material and methods: Our study included 116 patients with psoriatic arthritis (68 female, 48 male) and 41 patients in the psoriasis group (19 female, 22 male) and 90 subjects in the control group (55 female, 35 male). The demographic data of the patients, duration of disease, PAS', the nature of the disease were evaluated retrospectively. Results: Mean platelet volume levels of both the PV group (8.79 +/- 0.86 fl) and the PA group (9.18 +/- 1.26 fl) were significantly higher compared to the control group (8.42 +/- 0.74 fl). There was a weak statistically positive correlation between the PASI and the MPV according to the correlation analysis (r = 0.165; p = 0.046). Conclusions: Our results show that MPV may be helpful as an indicator of the clinical course of PV and PA. In this regard, that study should be supported by prospective studies to find strong correlations.Öğe C-reactive protein gene and Toll-like receptor 4 gene polymorphisms can relate to the development of psoriatic arthritis(Springer London Ltd, 2015) Akbal, Ayla; Oguz, Sevilay; Gokmen, Ferhat; Bilim, Serhat; Resorlu, Hatice; Sılan, Fatma; Uludağ, AhmetWe aimed to determine in psoriatic arthritis (PsA) patients the Toll-like receptor (TLR) 4 and C-reactive gene (CRP) polymorphisms and allele frequency and to investigate the relationship between clinical parameters and gene polymorphisms. We enrolled in this study 31 PsA and 41 healthy control subjects. PsA diagnosis was according to CASPAR criteria. Bath ankylosing spondylitis diseases activity index, Maastricht ankylosing spondylitis enthesitis score, and Bath ankylosing spondylitis functional index were measured. C, A, and T alleles of CRP and A and G alleles of TLR 4 were determined using the analysis of melting curves after real-time PCR. CRP A, C, and T allele frequency in controls was 26.8, 73.2, and 36.6 %, respectively. In the PsA patient group, A, C, and T allele frequency was 9.7, 87.1, and 12.9 %, respectively. Between control and PsA groups, there was a significant difference in A, C, and T allele frequency (P = 0.008, 0.038, and 0.001, respectively). The frequency of CRP gene polymorphisms (CA, AA, CT, TA, and TT alleles) in the control group was 56.1 % and in the PsA group was 22.6 %. There was a significant difference between the two groups (P = 0.004). The absence of a CRP gene polymorphism was a risk factor for PsA (odds ratio 4.3, 95 % CI; 1.5-12.4, P = 0.005). TLR gene haploid frequency was investigated, and all control subjects had the wild-type AA allele. PsA patient GA allele frequency was 6.5 %. There was no significant difference between the two groups (P = 0.182). GA mutant allele frequency was related to PsA (odds ratio 7.03, 95 % CI; 0.32-151.9, P = 0.214). We have shown that CRP gene polymorphisms are higher in control subjects than PsA patients, and TLR 4 gene polymorphisms were found to be related to PsA.Öğe Cubital tunnel syndrome secondary to gouty tophi: A case report(Pakistan Medical Assoc, 2017) Resorlu, Hatice; Zateri, Coskun; Akbal, Ayla; Gokmen, Ferhat; Adam, Gurhan; Bilim, Serhad; Bozkurt, EmreGout is a chronic rheumatic disease resulting from accumulation of monosodium urate crystals in tissues. The most important risk factor for the disease is hyperuricaemia. Precipitation of uric acid in the joint in the form of monosodium urate crystals is the main factor responsible for triggering attacks of arthritis. Tophi occur as a result of urate crystals that precipitate into joints and surrounding tissues. Tophi can erode the bone where they are located and cause compression in soft tissue due to a mass effect. The following case report describes a case of cubital tunnel syndrome developed in association with tophaceous compression and resolved with surgical decompression in a patient with chronic gouty arthritis.Öğe Dramatic Response to Methyl Prednisolone of Sacroiliitis due to Isotretinoin Theraphy: A Case Report(Galenos Yayincilik, 2020) Resorlu, Hatice; Kilic, Sevilay; Zateri, CoskunAcne vulgaris is a disorder that affects the pilosebaceous follicles on the skin. Isotretinoin is used in the treatment of severe acne and it may have side effects such as arthritis, myalgia, hyperostosis, sacroiliitis in the musculoskeletal system. Rarely seen sacroiliitis is usually recovered by discontinuation of isotretinoin. In this article, it was presented that a 19-year-old patient with bilateral and widespread sacroiliitis as a result of isotretionin use. Despite the use of non-steroidal anti-inflammatory drugs, sacroiliitis, which did not regress, responded dramatically to methyl prednisolone treatment.Öğe Effect of Systemically Used Anti-Tumor Necrosis Factor- Medication on the Corneal Epithelium and Stroma of Patients with Ankylosing Spondylitis(Taylor & Francis Inc, 2017) Arikan, Sedat; Gokmen, Ferhat; Ersan, Ismail; Akbal, Ayla; Resorlu, Hatice; Gencer, Baran; Ali Tufan, HasanPurpose: To evaluate the effect of systemically used anti-tumor necrosis factor alpha (TNF-alpha) medication on the thickness of corneal epithelium and stroma in patients with ankylosing spondylitis (AS). Methods: A total of 125 eyes of 69 participants were included in this retrospective study of three groups: healthy participants (Group 1), AS patients receiving anti-TNF-alpha medication (Group 2), and AS patients receiving a nonsteroidal anti-inflammatory medication (Group 3). Results: According to anterior segment optical coherence tomography, the mean thickness of the corneal epithelium was significantly thicker in Group 2 than in Group 3 (51.6 +/- 3.2 mu m versus 50.4 +/- 3 mu m, p = 0.01), as was that of the stroma (475 +/- 33 mu m versus 443 +/- 29 mu m, p = 0.002). Conclusions: Anti-TNF-alpha medication and/or avoidance of nonsteroidal anti-inflammatory drugs could improve the thickness of both the corneal epithelium and stroma in AS patients.Öğe Effect of Using High-Speed Drill in Anterior Cervical Discectomy and Fusion(Turkish Neurosurgical Soc, 2016) Guven, Mustafa; Ceylan, Davut; Aras, Adem Bozkurt; Akbal, Ayla; Gokmen, Ferhat; Resorlu, Hatice; Alkan, BahadirAIM: The objective of this study was to investigate the effect of using 2 different surgical techniques (curette or high-speed drill) in anterior cervical discectomy surgery on the healing of cases. MATERIAL and METHODS: Fifty-four operated cervical disc hernia cases were retrospectively examined in 2 groups. Discectomy and osteophytectomy were carried out in Group A by using a high-speed drill, while a curette was used for group B. Preoperative and postoperative computerized tomography and direct radiography were performed. Cervical disc height, cervical and segmental lordotic angles were calculated. The visual analogue scale and Odom's criteria were used in the assessment of pain and clinical healing. The fusion ratio of both groups was compared. The Mann-Whitney U test was used to compare data from the groups. RESULTS: Satisfactory results were obtained in the groups where high-speed drill and curette were used. Independently from the surgical technique, pain scores were significantly reduced in both groups after surgery. No radiologically significant differences were identified between the two groups within the postoperative period. CONCLUSION: Either high-speed drill or curette can be chosen for the osteophytectomy and discectomy stages of anterior cervical discectomy operations.Öğe Epicardial adipose tissue thickness in patients with ankylosing spondylitis(Springer London Ltd, 2015) Resorlu, Hatice; Akbal, Ayla; Resorlu, Mustafa; Gokmen, Ferhat; Ates, Can; Uysal, Fatma; Adam, GurhanThe purpose of our study was to measure epicardial adipose tissue (EAT) thickness as a novel indicator of atherosclerosis and cardiovascular risk factor in ankylosing spondylitis (AS) patients and to show the relationship with clinical parameters and inflammatory markers. Forty AS patients (42.75 +/- 12.43 years) and 40 healthy individuals with no cardiovascular risk factor as the control group (43.02 +/- 14.78 years) were included in the study. Carotid intima-media thickness (CIMT) and EAT thickness were measured in AS patients and the control group. Total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, glucose, erythrocyte sedimentation rate, urea, and blood pressure were investigated in both groups. In addition, the Bath Ankylosing Spondylitis Functional Index (BASFI) and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were used to evaluate the association between clinical findings and CIMT and EAT in the patient group. CIMT and EAT thickness were higher in the AS patients compared to the control group. CIMT was 0.76 +/- 0.19 and 0.57 +/- 0.12 mm (p < 0.001) and EAT thickness was 4.35 +/- 1.56 and 3.03 +/- 0.94 mm (p < 0.001) in the AS and control groups, respectively. A correlation was determined between EAT thickness and CIMT. Triglyceride level, patient age, blood pressure, and duration of disease were correlated with both CIMT and EAT thickness. Increased CIMT and EAT thickness in AS patients compared to the control group shows a risk for subclinical atherosclerosis and cardiovascular disease.Öğe Evaluation of paravertebral muscle atrophy and fatty degeneration in ankylosing spondylitis(Taylor & Francis Ltd, 2017) Resorlu, Hatice; Savas, Yilmaz; Aylanc, Nilufer; Gokmen, FerhatAim: The purpose of this study was to assess morphological changes in the paravertebral muscles in patients with ankylosing spondylitis. Materials and methods: Fifty-one patients diagnosed with ankylosing spondylitis and a 50 member control group were included in the study. The surface area of the multifidus and erector spinae muscles was measured at four levels between L1 and L5, and fatty degeneration in these muscles was scored. Lumbosacral and lumbar lordotic angles were determined for the patient and control groups. Results: Loss of muscle cross-sectional area compatible with atrophy was present at all four levels in the paraspinal muscles in patients with ankylosing spondylitis. A negative correlation was observed between paravertebral muscle area and duration of disease at three levels, but not at L1-2. Although muscle area decreased with the duration of disease at the L1-2 level, this was not statistically significant (r=-0.195, p=0.171). Comparison of intramuscular fatty degeneration between the groups revealed increased intramuscular fat at all levels in patients with ankylosing spondylitis, with the exception of L3-4, and a positive correlation between fatty degeneration and duration of disease was determined at all levels. Conclusion: Chronic inflammation, cytokine-mediated fibrosis, immobilization, and postural changes in ankylosing spondylitis contribute to fatty degeneration and atrophy in the paravertebral muscles.Öğe Evaluation the outcomes of patients with ankylosing spondylitis and rheumatoid arthritis treating with tumor necrosis factor-alpha blockers(Anatolian Journal of Clinical Investigation, 2015) Resorlu, Hatice; Kaya, Taciser; Günaydin, Rezzan; Göksel Karatepe, AltinayThe aim of this study were to monitor the clinical activity of the disease for 24 months in patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) treating with TNF-a blockers, to evaluate the response to treatment and effect to quality of life, to determine the side effect profile and frequency and to evaluate the cases decided to make switches due to side effects or ineffectiveness. Seventeen AS and 8 Ra patients were added to the study. All the parameters monitored throughout 24 months were recorded at 0, 3, 6, 12, 18 and 24 th months. Monitorization of the cases were carried out utilizing assesment parameters and response criteria recommended by ASAS for AS patient and using ACR disease activity measures and treatment response criteria for RA patients. Disability and quality of life of all patients were evaluated by Health Assessment Questionnaire-HAQ) ve short form- 36 (SF-36). The side effects observed along with treatment period were recorded. Seventeen patients with AS (4 female, 13 male) and 8 patients with RA (7 female, 1 male) were recruited into the study. The mean disease duration were 121.41 ±92.67 months and 162.50±131.91 months for patients with AS and RA respectively. Improvements at varying degrees were observed for disease activity, quality of life and disability status in AS and RA patients who were treated with TNF-a blockers. Particularly, improvement was more evident in self assessment scales. However, exacerbations were noted from time to time in the course of treatment, resulting in a need of a switch. Patients in an early disease stage and those with a better initial functional condition were found to reveal a beter treatment response. No serious infections, tuberculosis or no other severe side effects were observed. In the present study TNF-? blocker treatment was observed to be effective in inhibiting disease activity in AS and RA patients. Moreover, improvements were recorded for level of quality of life and disability status and no severe side effects were experienced. © 2015, Anatolian Journal of Clinical Investigation. All rights reserved.Öğe Giant Fibrolipoma Extending Throughout a Whole Extremity: A Rare Child Case Report(Derman Medical Publ, 2016) Aylanc, Nilufer; Golge, Umut Hatay; Aylanc, Hakan; Resorlu, Hatice; Goksel, FerdiWe present the case of a 4-year-old boy with congenitally asymmetrical lower extremities, his left being bigger than his right. The patient underwent imaging modalities after birth; a huge lipomatoid proliferation on his left thigh extended throughout the limb from the hip to the distal foot, showing isointensity with lipoid tissue. After surgical resection of his left foot, fibrolipoma was diagnosed. A giant fibrolipoma of the whole extremity occurring in a pediatric patient is a rarity.Öğe Increased Levels of Serum Ischemia Modified Albumin in Patients with Ankylosing Spondylitis(Clin Lab Publ, 2016) Turkon, Hakan; Gokmen, Ferhat; Cakir, Dilek Ulker; Sehitoglu, Muserref Hilal; Resorlu, Hatice; Doner, Davut; Essizoglu, ErtanBackground: The aim of the study was to investigate oxidant/antioxidant status by determining serum ischemia-modified albumin (IMA) levels with oxidative/antioxidant parameters in patients with ankylosing spondylitis (AS) compared to the controls. Methods: The serum concentrations of IMA, IMA/albumin ratio (IMAR), malondialdehyde (MDA), total oxidant status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), glutathione peroxidase (GPx), and total antioxidant capacity (TAC) were measured in 40 AS patients and 35 healthy controls. Results: Mean serum IMA, IMAR, MDA, TOS, and OSI levels were increased in patients with AS when compared to the control group (p < 0.05 for all). Serum levels of SOD and GPx were significantly lower in the patient group than in the healthy subjects (p < 0.001 for both). Serum TAC levels were decreased in patients with AS compared to the controls but the statistical difference was not significant. Serum IMA levels were found to be positively correlated with BASDAI, BASFI, BASMI, and ASDAS-CRP (r = 0.356, r = 0.370, r = 0.412, r = 0.353, respectively, and p < 0.05 for all). IMAR values showed significant correlations with BASFI, BASMI, and ASDAS-CRP (r = 0.351, p = 0.026; r = 0.400, p = 0.010; and r = 0.379, p = 0.016, respectively). Conclusions: Depletion in antioxidant systems and overproduction of free radicals leading to formation of the oxidative stress may play a role in the development of AS. Increased levels of IMA might provide important contributions to the underlying oxidative stress in AS.Öğe Neutrophil-Lymphocyte Ratio Connected to Treatment Options and Inflammation Markers of Ankylosing Spondylitis(Wiley, 2015) Gokmen, Ferhat; Akbal, Ayla; Resorlu, Hatice; Gokmen, Esra; Guven, Mustafa; Aras, Adem Bozkurt; Erbag, GokhanBackgroundIn recent years, white blood cells (WBCs) and their subtypes have been studied in relation to inflammation. The aim of our study was to assess the relationship between neutrophil-lymphocyte ratio (NLR) and ankylosing spondylitis (AS). Materials and methodsWe enrolled a total of 177 patients, 96 AS and 81 healthy controls. Complete blood count, WBC, neutrophil and lymphocyte levels were measured, and the NLR was calculated. In the assessment of AS, we used the erythrocyte sedimentation rate, C-reactive protein (CRP), the Bath Ankylosing Spondylitis Disease Activity Index, and the Bath Ankylosing Spondylitis Functional Index. ResultsIn the present study, 96 AS and 81 healthy individuals were enrolled. The mean age was 43.8 12.9 and 46.5 +/- 11.2 years, respectively. Mean disease duration of AS patients was 6.9 +/- 5.6 years (median = 5, min-max = 1-25). The patients with AS had a higher NLR than the control individuals (mean NLR, 2.24 +/- 1.23 and 1.73 +/- 0.70, respectively, P < 0.001). A statistically significant positive correlation was observed between NLR and CRP (r = 0.322, P = 0.01). The patients receiving antitumor necrosis factor therapy had a lower NLR than the patients receiving nonsteroidal anti-inflammatory drug therapy (mean NLR, 1.71 +/- 0.62 and 2.41 +/- 1.33, respectively, P = 0.02). ConclusionNLR may be seen as a useful marker for demonstrating inflammation together with acute phase reactants such as CRP and in evaluating the effectiveness of anti-TNF- therapy.
