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Öğe Assessment of Temperament and Character of Rheumatoid Arthritis Patients(Georg Thieme Verlag Kg, 2015) Gokmen, F.; Altinbas, K.; Akbal, A.; Celik, M.; Resorlu, H.; Gokmen, E.; Savas, Y.Objective: It is widely known that perception of disease affects clinical course and treatment response in patients with rheumatoid arthritis (RA). In this study we aim to define temperament and character properties of RA patients and to discuss the relation between these specific temperament and character properties and clinic variables. Methods: Study involved 93 RA patients. Temperament and character properties of patients were evaluated using Temperament and Character Inventory. Associations of clinical variables and specific temperament characteristics were evaluated using correlation and association analyses. Approval was obtained from institutional ethical commitee. Results: 74 (79.6 %) of study subjects were females and 19 (20.4 %) were males. Mean age of the patients was 53.3 +/- 11.5 years. There wasn't any difference between sociodemographic and clinical variables and temperament scores of patients according to gender (p > 0.05). Comparison of temperament features and clinical variables showed that there was a weak correlation between harm avoidance and Anticitrullinated Peptide Antibodies (p = 0.04, r = 0.22) and between reward dependance and Disease Activity Score (DAS 28). Regression analysis showed an association between reward dependance and DAS-28. Conclusion: Our findings indicated that there is an association between harm avoidance and reward dependance temperament properties of RA patients and disease activation, and disease course is more severe in patients who have high scores in these temperament dimensions. Therefore, adding assessment of temperament and character properties will help clinicians while evaluating treatment compliance and motivation of patients at initial and later stages of disease.Öğe Evaluation of the temperament and character properties of patients with ankylosing spondylitis(Springer Heidelberg, 2014) Gokmen, F.; Altinbas, K.; Akbal, A.; Celik, M.; Savas, Y.; Gokmen, E.; Resorlu, H.Purpose. The aim of this study was to evaluate temperament and character of ankylosing spondylitis (AS) patients and to examine the association between these specific temperament and character properties and clinical variables. Patients and methods. This study involved 73 AS patients. Temperament properties of patients were evaluated using Cloninger's Temperament and Character Inventory (TCI). Association between clinical variables and specific temperament features were evaluated using correlation and regression analyses. Results. Forty eight (65.8%) of the study participants were men and the mean age was 42+/-11.4 years. There was slight negative correlations between self directedness (S) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores (p=0.01, r=-0.30), and between the Visual Analog Scale (VAS) and reward dependence (RD) scores (p=0.03, r=-0.26). Regression analysis showed that correlations between BASDAI and S, and between VAS and RD scores were statistically significant. Conclusion. Our study showed that the dimensions temperament and character are related to disease activation, and disease course is more severe in patients who have low scores in these TCI dimensions. Therefore, we suggest that evaluating temperament and character properties of AS patients will help clinicians to predict treatment compliance and motivation of patients during disease course.Öğe Mean Platelet Volume and Neutrophil Lymphocyte Ratio as Related to Inflammation Markers and Anti-CCP in Rheumatoid Arthritis(Georg Thieme Verlag Kg, 2016) Gokmen, F.; Akbal, A.; Resorlu, H.; Binnetoglu, E.; Cevizci, S.; Gokmen, E.; Kose, M. M.Background: Various thrombocyte markers and white blood cell levels and their subtypes have recently been investigated in association with infl ammation. The purpose of this study was to determine the correlation of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) with disease activation and clinical parameters in rheumatoid arthritis (RA) patients. Methods: 84 RA patients and 60 healthy controls were included. Platelet, MPV, white cell, neutrophil and lymphocyte levels in full blood counts were investigated, and NLR was calculated. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), disease activation score (DAS 28) and a health assessment questionnaire (HAQ) were used in the evaluation of RA. Results: In the present study a total of 144 patients was enrolled, 84 with RA and 60 healthy individuals. 75.2 % (n = 108) were women and 24.8 % (n = 36) were men. The patients with RA had lower MPV than control individuals (MPV; 8.52 +/- 1.15 fL and 8.92 +/- 0.87 fL, respectively) and CRP (r: -0.234, p = 0.005). RA patients' mean NLR was signifi cantly higher than that of the control group (2.74 +/- 1.74 and 1.80 +/- 0.78, respectively; p < 0.001). Furthermore, anti-CCP positive patients had higher NLR than anti-CCP negative patients (NLR; 2.51 +/- 1.92 and 1.95 +/- 1.22, p = 0.019 respectively). NLR was positively correlated with ESR (r = 0.190, p = 0.023), CRP (r = 0.230, p = 0.035) and anti-CCP (r = 0.300, p = 0.005). Conclusion: In conclusion, MPV and NLR together with acute phase reactants can be a useful index for showing infl ammation in RA patients.Öğe Platelet indices can relate to bone mineralization: response to comments by Varol(Springer London Ltd, 2015) Akbal, A.; Resorlu, H.[Anstract Not Available]