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    Alpha-synuclein levels in multiple sclerosis patients with restless leg syndrome
    (Cukurova Univ, Fac Medicine, 2020) Cakina, Suat; Yucel, Selma; Polat, Cemre Cagan; Ozturk, Samil
    Purpose: The restless legs syndrome is more frequent and critical in Multiple Sclerosis patients, and it harms their general well-being and life quality. Alpha-synuclein is a synuclein protein that can have an impact on the pathway of signaling, affecting the Dopamin 2 receptor and its receptor trafficking. Studies have shown that the decrease in dopamine 2 receptor and Restless Legs Syndrome disease are correlated. This study is aimed to ascertain the alpha-synuclein level in multiple sclerosis patients with restless legs syndrome. Materials and Methods: We took blood samples from 40 multiple sclerosis patients and 20 healthy individuals. Half of the patient group had Multiple Sclerosis with restless leg syndrome. In the study groups, the alpha-synuclein level was determined by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-dependent immunosorbent assay (ELISA). Results: Alpha-synuclein gene expression level was found or be significantly lower in restless leg syndrome patients with multiple sclerosis than the Alpha-synuclein gene expression level in the control group. Conclusion: Alpha-synuclein may have an impact on the pathogenesis of the restless leg syndrome of multiple sclerosis disease. Further investigations are required to determine the impact of alpha-synuclein in the pathogenesis of restless leg syndrome in multiple sclerosis disease.
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    Epilepsy After Bee Sting: Case Report
    (Kare Publ, 2018) Polat, Cemre Cagan; Yucel, Selma; Tan, Tulay; Ozisin Karaman, Handan Isin
    Bee envenomations are one of the most common in all insect venomations. The usual clinical manifestation is local inflamation findings with a sudden burning pain. Rarely anaphylaxis, anxiety disorders, headache, chest pain, myocardial infarction, organ dysfunction and neurological disorders are reported. Bee venom has many components and these components have different effect on nervous system.
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    OXIDATIVE STRESS PARAMETERS IN PATIENTS WITH MIGRAINE WITHOUT
    (2020) Cakina, Suat; Yücel, Selma; Polat, Cemre Cagan; Oztürk, Şamil
    Aim: Migraine is a multifaceted neurological disease whose molecular mechanisms are not yet clearly defined. Oxidative stress is also believed to play a role in the pathogenesis of migraine. The purpose of this study was to evaluate serum paraoxonase (PON) and arylesterase (ARE) activities, thiols levels, ischemia-modified albumin (IMA), the total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in patients with migraine without aura. Materials and Methods: 30 patients (5 males and 25 females) and 30 matched healthy controls (8 males and 22 females) were enrolled. Serum PON and ARE activities, thiols levels, IMA, TAS, TOS and OSI were determined by using the spectrophotometric method in the study groups. Statistical analysis was conducted using Mann–Whitney U test and independent samples t-test, and p<0.05 was considered as statistically significant. Results: PON and ARE levels were significantly lower in the migraine without aura group compared with the control group p<0.05. Conclusion: Our results suggested that the PON and ARE levels might be associated with migraine without aura. In migraine patients, it is recommended that oxidative stress markers be investigated with a larger population and these parameters are taken into consideration.
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    Review of Seizures That Triggered by Energy Drinks With Two Cases
    (Kare Publ, 2020) Polat, Cemre Cagan; Yucel, Selma; Ozisik Karaman, Handan Isin
    Epilepsy is a disease that occur with abnormal discharge of brain neurons.Energy drinks use ise common in young people nowadays and that can trigger epileptic seizure.Taurine and caffeine as intense ingredients are being hold responsible of abnormal discharge.In this case we review relationship between seizures and energy drink with two cases.