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Öğe A giant chorioangioma of the placenta with favorable outcome: a rare case presentation with literature review(2016) Beyazit, Fatma; Göret, Ceren Canbey; Pek, Eren; Gencer, MeryemChorioangioma, or hemangioma of the placenta, is the most frequent non-trophoblastic tumor of the placenta consisting of blood vessels and stroma. A great proportion of these tumors are small and well delineated within the placental parenchyma and have no or minimal adverse impact on the fetus. Unfortunately, large tumor size is linked to serious complications such as fetal anemia, hydrops and intrauterine death. This is probably because of arteriovenous shunts leading to progressive heart failure of the fetus. With the increasing rates of antenatal screenings with ultrasonography, prenatal diagnosis of these tumors is widely achieved. Here we report a case of giant placental chorioangioma diagnosed in the second trimester of pregnancy. The size of the tumor minimally increased during follow-up and at term, uncomplicated labor was achieved. Macroscopic and histologic examination confirmed the diagnosisÖğe A rare case of complete penoscrotal transposition with hypospadias in a newborn(Galenos Yayincilik, 2017) Beyazit, Fatma; Pek, Eren; Aylanc, Hakan[Anstract Not Available]Öğe Alterations in sexual functions during and after pregnancy: Prejudice? Or Real?(Klinik Psikiyatri Dergisi, 2018) Beyazit, Fatma; Pek, Eren; Sahin, BasakSexual function in women is a complex and dynamic interaction of multiple variables including physical, emotinal, social, and physiological states. Moreover, sexual function is a key part of each human being's personality and a cornerstone in the overall couple relationship with an obvious affect on health related quality of life. A dysfunction in female sexual cycle can result in lack of desire for sexual contact, arousal and an inability to have an orgasm. Pregnancy is a period with many alterations in human physiology leading to challenges in sexual function. Endocrine, biologic, psychosomatic and social factors as well as anatomical alteations during pregnancy and the different mode of delivery may aggravate female sexual dysfunction. This literature review examines research articles that investigated female sexual function, sexual dysfunction, and sexual functioning in pregnancy in order to obtain how these parameters affect a woman's sexual related quality of life.Öğe Can hysteroscopy be substituted to hysterosalpingography in the assessment of infertility? Methods of showing tubal transition as hysteroscopic(Imr Press, 2022) Yanar, Buket Aydin; Pek, Eren; Unsal, Mesut A.Background: The main goal of this study was to prove that hysteroscopy is a superior method compared to hysterosalpingography in the evaluation of tubal passage and the uterine cavity in infertile women. Methods: The study was carried out on 30 volunteer women for whom evaluation of the uterine cavity and transit through the tubules was required due to infertility. In the evaluation of the hysteroscopic tubal passage, a 6Fr feeding cannula was advanced from the hysteroscope barrel, and firstly methylene blue and then an air bubble were applied to the fluid-filled uterine cavity through this flexible cannula. Results: When the reference method was taken as hysterosalpingography, the specificity of hysteroscopy was found to be 85.71% (95% CI (confidence interval): 42.13% 99.64%), sensitivity 94.74% (95% CI: 85.38-98.90%). The positive predictive value of hysteroscopy was calculated as 98.18% (95% CI: 89.78%-99.70%) and the negative predictive value was 66.67% (95% CI: 38.96%-86.24%). Observing the bubble and swirl effect together in the evaluation of the tube opening increases the diagnostic accuracy. And benefit of hysteroscopy in the evaluation of tubal passage was statistically significantly higher than hysterosalpingography. Conclusion: Considering the cellular damages that can be caused by hysterosalpingraphy and the real observation power provided by hysteroscopy, simultaneous evaluation and the comfort of making intervention possible, hysteroscopy will be a more useful and useful application.Öğe Cervical Dysplasia Distress Questionnaire: Turkish validity and reliability study(Routledge, 2023) Yılmaz, Büşra; Pek, Eren; Alan, Handan; Oskay, ÜmranThe aim of this study was to determine the validity and reliability of the Turkish adaptation of the Cervical Dysplasia Distress Questionnaire (CDDQ) in women with abnormal Pap smear results. This validation study was conducted using a cross-sectional research design. A total of 115 patients who were being followed up in the obstetrics and gynecology outpatient clinic of a university hospital due to an abnormal Pap smear test were included. In the study, the results of language and content validity, item analysis, exploratory, and confirmatory factor analyses, internal consistency coefficients, and concurrent and convergent validity were assessed in order to adapt the CDDQ to the Turkish language and culture and to determine its reliability and validity. It was determined that all factor loads of the scale ranged from 0.13 to 0.85. The exploratory variance was found to be 29.986 for the first subscale, 19.734 for the second subscale, 16.551 for the third subscale, and 66.271 for the overall scale. Cronbach’s alpha values for the tension during the examination, concerns about health consequences, and concerns about sexual consequences were 0.92, 0.91, and 0.87, respectively. The desired level of correlation was achieved between the CDDQ and the Hospital Anxiety and Depression Scale (HADS). In the study, the Turkish adaptation of the CDDQ was found to be a valid and reliable instrument to assess psychological distress in women with abnormal Pap smear results.Öğe CTLA4+rs231775 gene polymorphism increases PCOS, regardless of the levels of interleukin-6 and tumor necrosis factor-? in the serum(Bayrakol Medical Publisher, 2023) Beyazit, Fatma; Cicekliyurt, Meliha Merve; Turkon, Hakan; Unsal, Mesut Abdulkerim; Pek, ErenAim: Polycystic ovarian syndrome (PCOS) is a long-standing inflammation-related disease with increased levels of circulating pro-inflammatory markers. By affecting inflammatory cytokine production, cytotoxic T lymphocyte-associated antigen (CTLA-4) polymorphism can alter the immune system and trigger distinct disease states. The aim of the study was to investigate if CTLA4 polymorphism is associated with PCOS, and if so, (2) whether this situation influences serum interleukin-6 (IL-6) and TNF-alpha in PCOS.Material and Methods: CTLA4+rs231775 gene polymorphism with IL-6 and TNF-a levels were determined in 92 PCOS women and 88 healthy controls. Study groups were further subdivided according to body mass index (BMI) and the degree of insulin resistance (IR), and comparisons were made within each study group.Results: The prevalence of the A allele of single nucleotide polymorphism (SNP) rs231775 was more frequent in PCOS women compared with healthy controls [OR: 1.99, 95% CI:1.273-3.107, p =0.0023]. The heterozygous genotype was also shown to be strongly associated with PCOS development [OR: 3.041, 95%CI:1.604-5.766, p=0.0005]. Although TNF-a levels of PCOS patients were detected to be elevated, no difference was found in the study groups with respect to serum IL-6 levels. In addition, no association was observed between CTLA4+rs231775 polymorphism and serum pro-inflammatory cytokine levels.Discussion: The present study demonstrates for the first time that CTLA4+rs231775 gene polymorphism increases susceptibility to PCOS 2 times more in the case of A allele carriage and 3 times more in heterozygous individuals, independent from the long-standing low-grade inflammatory disease state encountered in patients with PCOS.Öğe Effects of vitamin B12, folate, uric acid, and serum biomarkers of inflammation on bone mineral density in postmenopausal women(Termedia Publishing House Ltd, 2018) Beyazit, Fatma; Pek, ErenIntroduction: Despite the accumulating evidence suggesting a possible relationship between femur and lumbar bone mineral density (BMD) and serum uric acid (UA), it is unclear whether alterations in UA levels reflect any underlying subclinical inflammatory conditions in postmenopausal osteoporosis. In addition, the mechanistic link between osteoporosis and dietary factors including vitamin B-1(2), and folate in postmenopausal women is still obscure. The aim of the present study is to investigate the association between serum vitamin folate, UA, and subclinical inflammatory markers and BMD measurements in postmenopausal women. Material and methods: One hundred and eighty-four postmenopausal women were recruited for the present study. Clinical data, as well as serum vitamin B-12, folate, UA, conventional inflammatory markers, and other related biochemical markers, were assessed for each subject. Bone mineral density measurements of proximal femur and lumbar spine were taken using dual-energy X-ray absorptiometry. Correlation analysis was performed between serum vitamin B-12, folate, UA and other biochemical and metabolic parameters. Results: Although no association was found between serum inflammatory markers, vitamin B-12 and folate levels with femur neck and lumbar spine BMD measurements, elevated UA levels were observed in subjects with normal BMD values. Higher BMD values were obtained in higher UA tertiles. UA (p < 0.001) and BMI (p = 0.003) were found to be correlated with femur neck BMD measurements. Conclusions: The femoral and lumbar BMD measurements were associated with serum UA levels. Higher serum UA levels were found to have a protective effect on postmenopausal osteoporosis irrespective of inflammation and dietary factors.Öğe Ektopik Gebelik Klinik Seyrini ve Tedavi Sonuçlarını Etkileyen Faktörlerin Retrospektif Analizi(2017) Beyazıt, Fatma; Pek, Eren; Çakır, Ayşenur Güngör; Gencer, Meryem; Uysal, Ahmet; Hacıvelioğlu, Servet; Ünsal, Mesut AbdulkerimAmaç: Ektopik gebelik (EG) embryonun uterin kavite dışında bir yerde implante olmasıyla karakterize ciddi bir medikal durumdur. Uygun tedavi verilmediğinde artmış morbidite ve mortalite ile ilişkilidir. Bu retrospektif çalışmanın amacı bir üçüncü basamak tedavi merkezi olan hastanemizde EG insidansı, klinik karakteristikleri, ve tedavi sonuçlarını analiz etmektir.Gereç ve Yöntemler: Bu çalışmada Çanakkale Onsekiz Mart Üniversitesi Kadın Hastalıkları ve Doğum kliniğinde 2011ve 2015 yılları arasında EG tanısı alan 79 hasta retrospektif olarak incelendi. EG hastalarının tıbbi bilgileri hastane kayıt sisteminden alınarak bu çalışma için tasarlanmış formlara kayıt edildi.Bulgular: Beş yıllık sürede kliniğimizde gerçekleşen 1920 doğum içinde 79 EG vakası saptandı. EG insidansı %4.1 olarak kayıt edildi. Tanı alan hastaların en sık gözlendiği yaş aralığı 30-34 (34.2%) yıl idi. Abdominal ve/veya pelvik ağrı %56.9 ile en sık gözlenen şikayetti. Tanı sıklıkla ultrasonografik incelemeler ve seri ?hCG ölçümleri ile konuldu. Tıbbi ve cerrahi yöntemler en sık başvurulan tedavi şekilleri idi.EG hastalarında mortalite izlenmedi.Sonuç: EG belirgin morbidite ve mortalite ile seyreden ciddi bir sağlık sorunu olmaya devam etmektedir. Ciddi komplikasyonların önlenmesi için erken ve uygun tedavi verilmesi son derece önemlidir. Bununla birlikte EG'den korunma ve erken tanı, tüplerin korunması ve cerrahi ihtiyacının azaltılması açısından özel bir önem taşımaktadır.Öğe Elevated circulating nitric oxide levels correlates with enhanced oxidative stress in patients with hyperemesis gravidarum(Taylor & Francis Inc, 2018) Beyazit, Fatma; Turkon, Hakan; Pek, Eren; Ozturk, Filiz Halici; Unsal, MesutSince the biochemical and molecular mechanisms responsible for ongoing oxidative stress in hyperemesis gravidarum (HEG) patients have not yet been fully elucidated, the aim of this study was to evaluate the possible role of nitric oxide (NO), malondialdehyde (MDA) and other oxidative stress markers in the disease pathophysiology. Moreover, the relation between oxidative stress markers and Helicobacter pylori (H. pylori) infection was also investigated. Women with pregnancies complicated by HEG (n=33) were compared with pregnant women without HEG (n=30) and with healthy non-pregnant women (n=31). Serum NO, MDA, total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and H. pylori infection status were determined for each subject. Serum NO levels and OSI index were found to be increased (p=.001 and .013, respectively) and TAS levels were decreased (p<.001) in HEG patients compared with both controls regardless of H. pylori infection status. Serum MDA and TOS levels were not different between the study groups. Helicobacter pylori infection rates were similar in each group. The reduced antioxidant activities, as well as the increased OSI and NO levels in HEG patients indicate possible oxidative stress conditions in HEG patients. Moreover, serum NO levels may be used as an adjunctive marker to distinguish HEG patients from other causes of emesis during pregnancy.Impact statementWhat is already known on this subject? Current evidence suggests that oxidative stress is a significant factor responsible for a number of complications during pregnancy.What do the results of this study add? Hyperemesis gravidarum is an oxidative stress condition, as reflected by increased nitric oxide (NO) and decreased total antioxidant status activity, regardless of H. Pylori infection.What are the implications for clinical practice and/or further research? Full disclosure of the association between circulating NO and hyperemesis gravidarum would shed light on underlying biological mechanisms and could help clinical management of similar pregnancy-associated morbidity states.Öğe Evaluation of the hematologic system as a marker of subclinical inflammation in hyperemesis gravidarum: a case control study(Via Medica, 2017) Beyazit, Fatma; Ozturk, Filiz Halici; Pek, Eren; Unsal, Mesut AbdulkerimObjectives: Current evidence suggests that subclinical inflammation plays a significant role in the development of hyperemesis gravidarum (HEG). Simple hematological markers, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have been shown to reflect inflammatory burden and disease activity in several disorders. This study aimed to determine the diagnostic value of these hematological parameters for HEG. Material and methods: A total of 54 HEG patients and 58 age-and gestational-age-matched control subjects were studied. NLR, MPV, PLR, platelet distribution width (PDW), and red cell distribution width (RDW) values in all patients were calculated and recorded from complete blood cell counts. Results: For HEG patients, the median NLR was 3.2 (1.6-7.1), and the median PLR was 143.7 (78.1-334.6); for control subjects, the values were 2.1 (1.0-4.7) and 93.1 (47.3-194.7), respectively. Although both the NLR and PLR of HEG patients were found to be significantly higher than in the controls, no significant difference was found between the study groups in terms of MPV, RDW, or PDW. Correlation analysis revealed a significant correlation between NLR and CRP (r = 0.872, p < 0.001). Conclusions: Our results show that peripheral blood NLR and PLR values can reflect inflammatory burden in HEG patients and can be used as markers for HEG.Öğe Impact of distinct factors affecting serum homocysteine levels in preeclamptic women(Springer Heidelberg, 2018) Pek, Eren; Beyazit, Fatma[Anstract Not Available]Öğe Infertility Associated with the Familial Mediterranean Fever (vol 20, 2019)(Galenos Yayincilik, 2019) Hacivelioglu, Servet; Gungor, Ayse Nur Cakir; Pek, Eren[Anstract Not Available]Öğe Is it possible to predict the success of single dose methotrexate in the treatment of tubal ectopic pregnancies?(Via Medica, 2023) Pek, Eren; Beyazıt, Fatma; Sıddıkoğlu, DuyguObjectives: In this study, the aim was to determine whether the use of endometrial thickness or neutrophil/lymphocyte and platelet/lymphocyte ratio would be useful in predicting the success of methotrexate in the treatment of ectopic pregnancies located in the fallopian tubes.Materal and methods:This study was carried out by retrospectively examining 68 study group cases with an ultrasono-graphically detectable gestational sac in the fallopian tubes and 189 control group cases with an unruptured ectopic pregnancy diagnosis at any location. The cut-off value of endometrial thickness was calculated as a new marker between the cases in which single-dose methotrexate treatment was successful and the cases with treatment failure. Treatment success was evaluated with different models including endometrial thickness, fetal cardiac activity status, measurable crown-rump length, and [3-hCG.Result: The cut-off value of [3-hCG for treatment success was determined as 2960.5 ng/mL, and the cut-off value for endometrial thickness was determined as 10.5 mm. Although NLR seems to be a marker with a cut-off value of 2.49, it does not provide an extra benefit in combined use as it is not a specific predictor. The highest success in predicting treat-ment success was achieved in the modeling in which crown-rump length + fetal cardiac activity + [3-hCG + endometrial thickness were used together.Conclusions: The use of endometrial thickness as a marker seems to be quite reliable in predicting treatment success. And we think it would be beneficial to thin the endometrium before using methotrexate.Öğe Letter to the Editor: the effect of folic acid supplementation on oxidative stress is strictly related to serum homocysteine levels(Springer Heidelberg, 2022) Beyazit, Fatma; Pek, Eren; Beyazit, Yavuz[Anstract Not Available]Öğe Maternal and foetal risks associated with teenage pregnancy - a comparative retrospective study in Turkey(Taylor & Francis Inc, 2024) Duran, Mehmet Nuri; Pek, Eren; Demir, Sureyya Saridas; Karacaer, Kubra Ozkan; Demir, BulentBackgroundAdolescent pregnancy is defined as pregnancy occurring in young women between the ages of 10 and 19 years. Adolescent pregnancies, which are among the social healthcare concerns in developed and developing countries, have negative effects on maternal and infant health. Pregnancy in adolescence puts the health of both the mother and child at risk, as adolescent pregnancies have higher rates of eclampsia, systemic infection, low birth weight, and preterm delivery compared to other pregnancies. In this study, the effects of education level, smoking, and marital status on maternal and foetal outcomes in adolescent pregnancies were evaluated.MethodsThe records of a total of 960 pregnant women (480 pregnant adolescents aged 15-19 years and 480 pregnant adult women aged 20-26 years) were examined retrospectively. The demographic data of the groups and maternal and foetal outcomes of the pregnancies were compared. A logistic regression model was established as a statistical method for reducing confounding effects.ResultsUnmarried women were statistically significantly more prevalent in the adolescent group (38.3% vs. 7.3%). Among the considered risk factors, preeclampsia (2.9% vs. 0.8%) and smoking (29.8% vs. 9.8%) were statistically significantly more common in the adolescent group. When the groups were compared in terms of risk factors in pregnancy, it was found that pregnancy in adolescence was associated with a 3.04-fold higher risk of smoking, 5.25-fold higher risk of being unmarried, 3.50-fold higher risk of preeclampsia, and 1.70-fold higher risk of intrauterine growth retardation (IUGR).ConclusionsThis study demonstrates an increased risk of preeclampsia, IUGR, and smoking during pregnancy in adolescent pregnant women. These findings can be used to identify adolescent pregnancies requiring specific assistance and to take measures to reduce the probability of adverse outcomes. In this study, we examine the risks of adolescent pregnancies. Adolescent pregnancy is a public health problem, and it is more common in underdeveloped or developing countries. We believe that non-governmental organisations and governments should take precautions regarding adolescent pregnancies and protect this legally vulnerable sociodemographic group from pregnancy. For healthier and more conscientious pregnancy experiences, mothers must be of appropriate age, having passed the period of adolescence. Adolescent pregnancies, which come with many risks, and especially risks of preeclampsia, premature birth, and maternal death, should be minimised or prevented.Öğe Postpartum Depression, Hypomania, Emotion Regulation Difficulties and Evaluation of Their Relationships(2022) Pek, Eren; Taş, Halil Ibrahim; Altınbaş, KürşatIntroduction: Postpartum depression is associated with complications that can endanger the health of both the mother and indirectly the baby. It is especially important to screen for hypomanic symptoms in this period and to differentiate between unipolar and bipolar bi polar disorders. On the other hand, difficulties experienced in the regulation of emotions may be important in describing unip olar or bipolar disorders that may be observed in this period. For this reason, it is aimed to investigate how postpartum depr ession, hypoman ic symptoms and emotions are regulated in the postpartum period and the relationships between these phenomenologies. Materials and Methods: This study was carried out by evaluating 164 puerperant women who did not have any complicated or negative experiences during pregnancy and delivery, who did not have a family history in terms of psychiatric disorders, and who agreed to be a participant, on the tenth postpartum day. All cases read and answered by them; were evaluated with the Turkish versions of the modified hypomania checklist (mHCL), Edinburgh postpartum depression scale (EPDS), and difficulty in emotion regulation scales (DERS). Results: The mean EPDS score was 7.39 ± 2.45, and the results obtained in 7.9% of th e cases were above the cut-off point. The mean of hypomania evaluation scores was calculated as 5.14 ± 2.71. However, the rate of those with at least three hypomanic symptoms was 85.3%, and the rate of those with at least five hypomanic symptoms was 55.5%. Correlations were observed between ' impulse, clarity, and non-acceptance ' subtypes of the DERS scale and hypomanic symptoms. However, it was determined that they did not show any correlation with the scores obtained from EPDS. Conclusion: It seems that identifying difficulties in emotion regulation may be important in differentiating hypomanic symptoms in the postpartum period. In this period, the distinction between unipolar depression and bipolar disorder is particularly difficult and requires careful evaluation. For this reason, we believe that it would be more beneficial to use clinical interviews, which include emotion regulation difficulties, in evaluations.Öğe Predictive value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Vaginitis(Professional Medical Publications, 2021) Pek, Eren; Beyazit, Fatma; Şen Korkmaz, NilayObjectives: This study was conducted to evaluate the diagnostic value of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in vaginitis patients. Methods: This cross-sectional retrospective study was performed in Afyon Dinar State Hospital between July 2016 to August 2017. A total of 64 bacterial vaginosis (BV) patients, 66 vulvovaginal candidiasis (VVC) patients and 65 age-matched control subjects were enrolled. NLR, PLR, mean platelet volume (MPV), red cell distribution width (RDW) and other conventional inflammatory marker values were recorded for all patients before and after treatment. Results: In the BV group, NLR values were found to be elevated compared to VVC and healthy controls [2.9 (1.2-14.7), 2.1 (1.1-11.7) and 2.1 (0.8-7.0), respectively] (p=0.008). Although not found to be statistically significant, the median NLR levels of BV patients decreased from 2.9 (1.2-14.7) to 2.4 (1.2-7.0) after treatment. PLR levels did not show a statistically significant difference between the three groups (p=0.970). The cut-off value of the NLR for BV was 2.19, with 67.2% sensitivity and 63.8% specificity. Conclusions: The present study demonstrated that NLR levels are elevated in bacterial vaginosis and NLR levels can be used as a reflection of systemic inflammatory response in vaginosis patients.Öğe Recurrence of borderline ovarian tumors: clinical and pathological risk factors(IMR Press Limited, 2021) Şahin, Hacı Öztürk; Yılmaz, Alpay; Bayrak, Mehmet; Pek, Eren; Özerkan, Kemal; Ozan, HakanObjective: The objective of this study was to determine the impact of several clinic pathologic factors on the rate of recurrence of borderline ovarian tumors (BOT). Method: Patients, who were diagnosed in our clinic between October 1996 and April 2016 with a final diagnosis of BOT, were retrospectively investigated. Only patients with a primary diagnosis of BOT were included. A total of 147 patients were diagnosed with BOT and underwent surgical treatment. The pathological reports, medical records and operation notes of the included patients were obtained from the gynecological oncology electronic database system. Results: While 51.7% of all our patients had BOTs of serous histology, 34.6% had mucinous BOTs and 13.6% had seromucinous BOTs, and their bilaterality was 11.8%, 2% and 5%, respectively. After treatment, the clinical conditions of 96 patients could be followed and recurrence was observed in six (6.3%) of them. The median follow-up time was 66 months (range: 12–266 months). The median time to recurrence was 46 months (range: 14–100 months). For non-recurrence and recurrence cases, the median age was 42.0 years (range: 17–86) years and 29.0 years (range: 18–32 years), respectively a statistically significant difference (p = 0.005). Thirteen percent of the patients who underwent conservative surgery had recurrence, whereas no recurrence was observed in patients without conservative surgery (p = 0.009). While no recurrence was observed in patients who were surgically staged as stage 1, recurrences developed in cases with stage 2 and 3 disease (p = 0.040). In this cohort histologic type, surgical staging, presence of implants, size of the tumor, presence of micropapillary variants, and lymphadenectomy were not associated with recurrence. Conclusion: We found the recurrence of BOT is associated with younger age at diagnosis and conservative surgery. Although we found no statistically significant association of BOT recurrences with surgical staging, among those who were surgically stage recurrences only occured in patients with stage 2 or 3 disease.Öğe Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum(Galenos Yayincilik, 2018) Beyazit, Fatma; Pek, Eren; Turkon, HakanAim: Hyperemesis gravidarum (HEG) is characterized by severe nausea and vomiting, weight loss and nutritional deficiency. Although exact cause of this condition is still a matter of debate, contribution of oxidative stress to pathogenesis of HEG was demonstrated in some studies. The aim of this study was to investigate the diagnostic value of ischemia-modified albumin (IMA) concentration and IMA/albumin ratio (IMAR) in HEG patients. Methods: One patient group and two control groups were constituted. Pregnant subjects with HEG were included in HEG group (n=31) and age-, gestational age-, and body mass index (BMI)-matched healthy pregnant women in control group (n=30). The second control group was constituted from age- and BMI-matched non-pregnant women (n=30). Serum IMA, IMAR blood glucose, albumin, urea, creatinine, alanine aminotransferase and aspartate aminotransferase levels were measured in all subjects. Results: Serum median IMA levels [0.55 (0.43-0.68)] was found to be elevated in HEG patients compared with pregnant [0.52 (0.34-0.61)] and non-pregnant controls [0.48 (0.27-0.57)] (p=<0.001). IMAR levels were also found to be significantly elevated in HEG patients compared to both control groups. According to correlation analysis, IMA and IMAR levels were only correlated with C-reactive protein levels. Conclusion: Elevated levels of IMA and IMAR in HEG patients might be due to ischemic intrauterine environment.Öğe Sociodemographic and pathological characteristics of women who underwent endometrial curettage for abnormal uterine bleeding in a university referral center(2018) Beyazıt, Fatma; Aydın, Buket; Pek, Eren; Ünsal, MesutAbnormal uterine bleeding (AUB) is an important clinical concern among reproductive-aged women, and is usually associated with benign or malignant gynecologic conditions. The aim of the present study is to determine the clinical spectrum of AUB patients and to investigate the relationship between indications and histopathological results of AUB patients undergoing endometrial sampling. A total of 625 female patients who presented to Canakkale Onsekiz Mart University Hospital between October 2013 and October 2017 due to non-obstetric gynecological causes and underwent endometrial sampling included in the present study. The median age of patients was 46 years (min-max: 28-90 years) and the most common clinical presentation was represented by menometrorrhagia/menorrhagia (50.4%) followed by postmenopausal bleeding (38.6%), and myoma uteri (9.3%). Endometrial sampling evaluation revealed various patterns on histopathology. The most common encountered diagnosis was proliferative-secretory endometrium (41.3%), followed by endometrial polyp (20.2%) and simple hyperplasia without atypia (9.6%). Endometrial cancer was observed more frequently in the post-menopausal bleeding. AUB which often prevails as an important and common gynecological ailment in perimenopausal women is commonly due to dysfunctional in origin. Therefore routine endometrial biopsy should not be an initial clinical investigation for menorrhagia. It should be preferred in case of persistent menorrhagia in conjunction with presence of additional risk factors.
