Yazar "Ozsoy, Fatma" seçeneğine göre listele

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    Öğe
    Enhanced drug carrier capacity after post modification process for amino acid substitute phosphazene based microspheres with anticancer activity
    (Elsevier, 2023) Ozsoy, Fatma; Özay, Özgür
    In this study, drug carrier HCCP-PP-LEEMP microspheres were synthesized by using Hexachlorocyclotriphosphazene (HCCP), Phenolphthalein (PP) and L-Lysine Ethyl Ester Dihydrochloride (LEE) by polycondensation reaction. The synthesized spheres were modified in an acidic environment, and a cationic charge was formed on their surfaces. Synthesized and quaternized microspheres were characterized using FT-IR, SEM, TEM, TGA and Zeta (& zeta;) potentials analyzes. HCCP-PP-LEE-ATA-QMP microspheres with increased anionic drug carrying capacity as a result of quaternization were used as carriers for Sodium Diclofenac (NaDc) and Cimetidine drugs. While the unmodified HCCP-PP-LEEMP microspheres did not retain the NaDc drug, the NaDc drug retention capacity of the quaternized HCCP-PP-LEE-ATA-QMP microspheres was calculated as 99.6677 mg/ g. Thus, it was determined that the drug holding capacity of the microspheres could be increased tens of times compared to their initial state, thanks to the positive charges formed on the surface of the drug carrier micro spheres as a result of quaternization. At the same time, Cimetidine, a type of chemotherapeutic drug, was loaded into the microsphere using as drug delivery system. In vitro drug release behaviors of the developed phosphazene and amino acid-based delivery system were investigated and drug release kinetic models were determined. In addition, the antibacterial and antifungal effects of the microspheres were investigated with the effect of LEE in the structure of the microspheres. Then, the anticancer behavior of the cimetidine-loaded microspheres was tested on HT-29 colon cancer cell lines. Thus, a potential carrier system that can carry drugs for the treatment of a selective disease or chemotherapeutics for the treatment of cancer has been synthesized.
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    Öğe
    Graphene nanoplate incorporated Gelatin/poly(2-(Acryloyloxy)ethyl trimethylammonium chloride) composites hydrogel for highly effective removal of Alizarin Red S from aqueous solution
    (Springer, 2022) Ozsoy, Fatma; Ozdilek, Batuhan; Onder, Alper; Ilgin, Pinar; Ozay, Hava; Özay, Özgür
    The increasing water pollution day by day has increased the importance of developing new adsorbent materials. In this study, composite hydrogel containing gelatin, [2-(Acryloyloxy)ethyl] trimethylammonium chloride (AETAC) and Graphene Nanoplate (GNPt) was developed as an adsorbent for the removal of dyes from wastewater. Fourier Transform Infrared Spectrophotometer, Scanning Electron Microscope, X-Ray Diffractometer results confirmed the crosslinked polymer structure of Gelatin/p(AETAC)/GNPt composite hydrogel (Gel 5). In addition, equilibrium swelling ratio, which is a parameter affecting the adsorption behavior, was 48.22 g(water) /g(gel). The adsorption behavior of Alizarin Red S anionic dyestuff on composite hydrogel from aqueous solutions was investigated under various experimental conditions such as initial dye concentration of solution, amount of adsorbent, contact time, pH of solution, temperature of solution. ARS dye adsorption on composite hydrogel is consistent with Pseudo-Second-Order kinetic model and Langmuir isotherm with max adsorption capacity of 649.35 mg/g. The composite hydrogel with high mechanical strength has high dye removal ability in the ranging pH from 4 to 8. Therefore, it can be said that Gelatin/p(AETAC)/GNPt composite hydrogel has a substantial potential for the removal of anionic dyes from wastewater in a wide pH range.
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    Öğe
    Self-assembled silibinin-containing phosphazene/cystamine hybrid nanospheres as biodagradable dual-drug carriers with improved anticancer activity on a breast cancer cell line
    (Elsevier, 2023) Ozsoy, Fatma; Onder, Ferah Comert; Ilgin, Pinar; Ozay, Hava; Onder, Alper; Özay, Özgür
    In this study, pH and redox sensitive biodegradable PPZs@Silibinin polymeric nanospheres were synthesized by the polymerization reaction of Hexachlorocyclotriphosphazene (HCCP), Cystamine dihydrochloride (CA) and the anticancer drug Silibinin as monomers. Later designed as a therapeutic system, this nano drug-carrier was also loaded with Doxorubicin (Dox), a type of cancer drug. As a result, a drug self-delivery system (DSDS) was developed, which had the property of biodegradation in tumor tissues thanks to the redox active disulfide bonds in its structure from pH-sensitive nanospheres containing two anticancer drugs. Biodegradation-associated in vitro release of cancer drug (Dox) from the Dox loaded PPZs@Silibinin nano drug-carrier was performed in the presence of glutathione (GSH) at pH 6.5 and pH 7.4. While 93.06% Dox release was observed in pH 6.5 medium containing 10 mM GSH in 24 h, this value was 56.60% in pH 7.4 + 10 mM GSH medium. In addition, clonogenic analysis and cytotoxicity studies were performed on the MDA-MB-231 cell line to determine the anticancer properties of PPZs@Silibinin loaded with Dox. It was determined that PPZs@Silibinin@Dox nanospheres containing 20.5 nM Dox for 0.75 mu L are highly effective in MDA-MB-231 cells than free Dox.