Yazar "Ozleyen, Adem" seçeneğine göre listele

Listeleniyor 1 - 5 / 5
  • [ X ]
    Öğe
    In vitro and in silico studies of nitrobenzamide derivatives as potential anti-neuroinflammatory agents
    (Taylor & Francis Inc, 2020) Kulabas, Seda Savranoglu; Onder, Ferah Comert; Yilmaz, Yakup Berkay; Ozleyen, Adem; Durdagi, Serdar; Sahin, Kader; Ay, Mehmet
    Communicated by Ramaswamy H. Sarma
  • [ X ]
    Öğe
    Multitarget Profiling of a Strigolactone Analogue for Early Events of Alzheimer's Disease: In Vitro Therapeutic Activities against Neuroinflammation
    (Amer Chemical Soc, 2020) Kurt, Begum; Ozleyen, Adem; Antika, Gizem; Yilmaz, Yakup Berkay; Tumer, Tugba Boyunegmez
    Neuropathological changes in Alzheimer's disease (AD) are directly linked to the early inflammatory microenvironment in the brain. Therefore, disease-modifying agents targeting neuroinflammation may open up new avenues in the treatment of AD. Strigolactones (SLs), subclasses of structurally diverse and biologically active apocarotenoids, have been recently identified as novel phytohormones. In spite of the remarkable anticancer capacity shown by SLs, their effects on the brain remained unexplored. Herein, the SIM-A9 microglial cell line was used as a phenotypic screening tool to search for the representative SL, GR24, demonstrating marked potency in the suppression of lipopolysaccharide (LPS)-induced neuroinflammatory/neurotoxic mediators by regulating NF-kappa B, Nrf2, and PPAR gamma signaling. GR24 also in the brain endothelial cell line bEnd.3 mitigated the LPS-increased permeability as evidenced by reduced Evans' blue extravasation through enhancing the expression of tight junction protein, occludin. Collectively, the present work shows the anti-neuroinflammatory and glia/neuroprotective properties of GR24, making SLs promising scaffolds for the development of novel anti-AD candidates.
  • [ X ]
    Öğe
    Natural Products and Synthetic Analogs as a Source of Antitumor Drugs
    (Mdpi, 2019) Sharifi-Rad, Javad; Ozleyen, Adem; Tumer, Tugba Boyunegmez; Adetunji, Charles Oluwaseun; El Omari, Nasreddine; Balahbib, Abdelaali; Taheri, Yasaman
    Cancer is a heterogeneous disease and one of the major issues of health concern, especially for the public health system globally. Nature is a source of anticancer drugs with abundant pool of diverse chemicals and pharmacologically active compounds. In recent decade, some natural products and synthetic analogs have been investigated for the cancer treatment. This article presents the utilization of natural products as a source of antitumor drugs.
  • [ X ]
    Öğe
    Plants of the genus Spinacia: From bioactive molecules to food and phytopharmacological applications
    (Elsevier Science London, 2019) Salehi, Bahare; Tumer, Tugba Boyunegmez; Ozleyen, Adem; Peron, Gregorio; Dall'Acqua, Stefano; Rajkovic, Jovana; Naz, Rabia
    Background: Spinacia plants, including the most recognized species of the genus Spinacia oleacea L. (spinach), have high nutritional value and high content in phytochemicals, such as flavonoids, polyphenols, carotenoids, and ascorbic acid. However, the amount of these phytochemicals depends on several factors, such as genotype, climatic conditions, and agronomic practices, harvesting, storage temperature and time. Scope and approach: This review focus on the therapeutic role of Spinacia genus as well as its contribution as food in industry. A special emphasis is also given to its biological activities including antioxidant and antimicrobial effects. Finally, the clinical efficacy of Spinacia plants, the respective roles, and mechanisms of bioactive compounds on human health are covered. Key findings and conclusions: Spinacia plants are rich in nitrate, thylakoids, glycoglycerolipids and their natural antioxidant mixture (NAO) shows renowned antioxidant, antiproliferative, anti-inflammatory, antimicrobial, anticancer and cardioprotective effects. Thus, the nutritional value and phytochemical composition of Spinacia plants make them an excellent matrix to be used in traditional medicine as also as a natural preservative ingredient in food.
  • [ X ]
    Öğe
    Symphytum Species: A Comprehensive Review on Chemical Composition, Food Applications and Phytopharmacology
    (Mdpi, 2019) Salehi, Bahare; Sharopov, Farukh; Tumer, Tugba Boyunegmez; Ozleyen, Adem; Rodriguez-Perez, Celia; Ezzat, Shahira M.; Azzini, Elena
    Symphytum species belongs to the Boraginaceae family and have been used for centuries for bone breakages, sprains and rheumatism, liver problems, gastritis, ulcers, skin problems, joint pain and contusions, wounds, gout, hematomas and thrombophlebitis. Considering the innumerable potentialities of the Symphytum species and their widespread use in the world, it is extremely important to provide data compiling the available literature to identify the areas of intense research and the main gaps in order to design future studies. The present review aims at summarizing the main data on the therapeutic indications of the Symphytum species based on the current evidence, also emphasizing data on both the efficacy and adverse effects. The present review was carried out by consulting PubMed (Medline), Web of Science, Embase, Scopus, Cochrane Database, Science Direct and Google Scholar (as a search engine) databases to retrieve the most updated articles on this topic. All articles were carefully analyzed by the authors to assess their strengths and weaknesses, and to select the most useful ones for the purpose of review, prioritizing articles published from 1956 to 2018. The pharmacological effects of the Symphytum species are attributed to several chemical compounds, among them allantoin, phenolic compounds, glycopeptides, polysaccharides and some toxic pyrrolizidine alkaloids. Not less important to highlight are the risks associated with its use. In fact, there is increasing consumption of over-the-counter drugs, which when associated with conventional drugs can cause serious and even fatal adverse events. Although clinical trials sustain the folk topical application of Symphytum species in musculoskeletal and blunt injuries, with minor adverse effects, its antimicrobial potency was still poorly investigated. Further studies are needed to assess the antimicrobial spectrum of Symphytum species and to characterize the active molecules both in vitro and in vivo.