Yazar "Ozkul, Faruk" seçeneğine göre listele
Listeleniyor 1 - 16 / 16
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A new technique to simplify the minimally invasive parathyroidectomy: Ultrasound-assisted guided wire localization for solitary parathyroid adenomas(Pakistan Medical Assoc, 2016) Ozkul, Faruk; Arik, Muhammed Kasim; Eroglu, Mustafa; Faydaci, Umut; Toman, Huseyin; Tas, Sukru; Ukinc, KubilayObjective: To investigate the benefits of ultrasound-assisted guided wire localization in MIP for selected cases. Methods: In this prospective, nonrandomised study, we included 36 patients with solitary parathyroid adenomas diagnosed preoperatively by 99m Tc sesta MIBI scintigraphy and/or neck ultrasonography. An ultrasound-guided wire was placed in the solitary parathyroid adenoma preoperatively. MIPs were performed under local anaesthesia plus sedation. After the excision, the parathyroidectomy was confirmed with postoperative ultrasonography. Results: There were 36 patients included in our study. The mean age was 54.89 +/- 11.28 years, and 30 patients were females (83.3%). Preoperative PTH and calcium (Ca) levels were 269.5 pg/mL (83.5-5,000 pg/mL) and 12.2 mg/dL (11.1-20 mg/dL), respectively. Postoperative serum PTH and Ca levels were 42.04 +/- 26.65 pg/mL and 8.95 +/- 0.74 mg/dL, respectively. The mean operation time was 21.69 +/- 6.4 minutes and the average hospitalisation time was 18 hours (range: 10-72 hours). Conclusions: Ultrasound-assisted guided wire localization may be useful in selected MIP cases. The MIP advantages include higher success rates and being easy to learn and practise.Öğe Agenesis of Isthmus of the Thyroid Gland in a Patient with Graves-Basedow Disease and a Solitary Nodule(Hindawi Ltd, 2013) Ozkan, Omer Faruk; Asik, Mehmet; Toman, Huseyin; Ozkul, Faruk; Cikman, Oztekin; Karaayvaz, MuammerThe thyroid is a vascular endocrine gland with two lateral lobes connected by a narrow, median isthmus. Although a wide range of congenital anomalies of the thyroid gland has been reported in the literature, agenesis of the thyroid isthmus is a very rare congenital anomaly Thyroid isthmus agenesis does not manifest clinical symptoms, and it can be confused with other thyroid pathologies. We describe a patient with no isthmus of the thyroid, associated with Graves-Basedow disease. Thyroid isthmus agenesis should be kept in mind in order for surgical procedures involving thyroid pathologies to be carried out safely.Öğe Co-occurrence of Papillary and Follicular Thyroid Carcinoma in a Patient with Hodgkin's Disease(Galenos Yayincilik, 2013) Asik, Mehmet; Ozkul, Faruk; Toman, Huseyin; Durmus, Ahmet; Anaforoglu, Inan; Gunes, Fahri; Akbal, Erdem[Anstract Not Available]Öğe Delayed graft function in living-donor renal transplantation: a single-center experience with 1537 patients(E-Century Publishing Corp, 2016) Ozkul, Faruk; Erbis, Halil; Yilmaz, Vural Taner; Ozturk, Bunyamin; Kocak, Huseyin; Osmanoglu, Ibrahim Ali; Dinckan, AyhanObjectives: To analyze the incidence, clinical characteristics and possible causes of delayed graft function (DGF) among a large number of living kidney transplant recipients at a single center. Patients and Methods: We analyzed the medical records of 1537 patients over 18 years of age who received a kidney transplant from a living donor between January 2003 and June 2014. The demographic characteristics of the patients, graft survivals, acute rejection rates and renal functions were compared between patients with and without DGF. Results: Longer dialysis time before transplantation (50.6 +/- 53.1 vs. 31.4 +/- 42.9 months; P<0.001) and lower donor GFR (48.2 +/- 10.2 vs. 45.4 +/- 13 months; P=0.014) were associated with a greater incidence of DGF in this series. The DGF cases showed a higher incidence of acute rejection episodes (19.9% vs. 4.8%), chronic graft dysfunction (10% vs. 1%), prolonged hospitalization (16.8 +/- 6.7 days vs. 8.3 +/- 5.6 days), and worse renal function after 1-year follow-up period compared with non-DGF patients. Conclusions: Longer dialysis time before transplantation and lower donor GFR were associated with a higher risk for DGF, with prolonged hospitalization time, worse graft prognosis and higher rates of acute rejection episodes and chronic graft dysfunction.Öğe Effect of age on the outcome of renal transplantation: A single-center experience(Professional Medical Publications, 2016) Ozkul, Faruk; Erbis, Halil; Yilmaz, Vural Taner; Kocak, Huseyin; Osmanoglu, Ibrahim Ali; Dinckan, AyhanObjectives: To analyze the effects of old age on renal transplantation (Tx) results and graft survival, and compared elderly patient population with the young patients. Methods: A total of 1946 renal transplant were performed from 1537 living and 409 cadaveric donors between 2003 and 2014. The recipients were divided into two groups according to their age at the time of transplantation. The young age group consisted of 18 -59-year-old, and the elderly group consisted of the ones >= 60 years. Results: Acute rejection was seen in 19.5% of the young age group while this rate was 16.7% in the old age group (p=0.535). DGF was seen in 6.3% of the young age group, and in 13.5% of the old age group (p<0.001). Analysis of the overall survival rates demonstrated that 1.6% of the patients in the young age group and 6.8% of the patients in the old age groups died (p=0.003). Conclusions: Renal transplant had high graft survival rates in the elderly as in the young patients. However, the risks for complications were higher in the older age group compared to the younger age group. Thus, it is important to make a careful selection among elderly candidates for renal transplantation.Öğe Effects of sugammadex on the prevention of postoperative peritoneal adhesions(Wiley, 2015) Sahin, Hasan; Toman, Huseyin; Kiraz, Hasan Ali; Simsek, Tuncer; Erbas, Mesut; Ozkul, Faruk; Arik, Muhammet KasimMany materials and techniques have been used to prevent and repair intra-abdominal adhesions, but an effective solution has not been found. The aim of this study is to research the effect of sugammadex on intra-abdominal adhesions in an experimentally induced intraabdominal adhesion model. Twenty-four female Wistar albino rats were included in the study. The experimental animals were randomly divided into three groups: the sugammadex group (Group SX, n=8), the control group (Group C, n=8), and the shamgroup (Group S, n=8). After starvation for 1 night, the rats were injected with a 50 mg/kg intramuscular dose of ketamine and a 5 mg/kg intramuscular dose of xylazine for anesthesia. The rats in the SX group were given 3 mL sugammadex into the peritoneal cavity, while rats in the control group were given 3 mL 0.9% sodium chloride. In the sham group, the peritoneal cavity was opened, but no chemicals were administered. All rats were sacrificed on the 10th postoperative day. The adhesions were staged as 0, 1, 2, and 3 according to Evans et al.'s model. Our evaluation of macroscopic adhesion intensity found statistically significant differences between the groups. The sugammadex group was observed to have fewer adhesions in a statistically significant manner compared with the control group (p < 0.05). In our experimental intra-abdominal adhesion model in rats, we observed that sugammadex prevented postoperative intra-abdominal adhesions. Copyright (C) 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.Öğe EVALUATION OF EPICARDIAL FAT TISSUE THICKNESS AND CAROTID INTIMA MEDIA THICKNESS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM AFTER PARATHYROIDECTOMY(Carbone Editore, 2017) Eroglu, Mustafa; Ozkul, Faruk; Erbag, Gokhan; Temiz, Ahmet; Altun, Burak; Arik, Kasim; Sen, HacerIntroduction: It has been shown that epicardial fat tissue (EFT) thickness in primary hyperparathyroidism (PHPT) is increased and that this is closely associated with cardiovascular disease and atherosclerosis. However, EFT thickness in patients with hyperparathyroidism who were treated with parathyroidectomy has not yet been studied. In this study we aimed to examine whether carotid intima-media thickness (CIMT) and EFT thickness would be affected after treatment of PHPT by parathyroidectomy. Materials and methods: 27 patients with PHPT who were diagnosed with a parathyroidectomy indication and 39 healthy volunteers were included in the study. For all patients with PHPT, anthropometric measurements were made before and 12 months after parathyroidectomy, and EFT thickness, CIMT, serum parathormone (PTH), calcium and lipid levels were measured. Results: It was observed that preoperative CIMT and EFT thickness in patients with PHPT were significantly higher than the control group (for both p<0.001). Although hyperparathyroidism and hypercalcemia of the patients improved after parathyroidectomy, no significant change in the thickness of CIMT or EFT was determined. Conclusions: CIMT and EFT thickness seem to be good cardiovascular indicators for diagnosis of patients with PHPT. Nevertheless, this study raises the question of the reliability of a decrease in these parameters in patient follow-up. It is therefore necessary to be more careful in evaluating these parameters after treatment of patients with PHPT.Öğe Evaluation of epicardial fat tissue thickness in patients with Hashimoto thyroiditis(Wiley-Blackwell, 2013) Asik, Mehmet; Sahin, Sinan; Ozkul, Faruk; Anaforoglu, Inan; Ayhan, Semiha; Karagol, Sukriye; Gunes, FahriObjective Hypothyroidism, whether overt or subclinical, has multiple effects on the cardiovascular system. Epicardial fat tissue (EFT) is closely related to cardiovascular disorders and atherosclerosis. Our study aimed to assess EFT thickness and carotid artery intima-media thickness (CIMT) in patients with Hashimoto's thyroiditis (HT) displaying overt and subclinical hypothyroidism (SCH). Design and patients The study included 33 patients with SCH and 24 patients with overt hypothyroidism (OH) with HT as well as 32 healthy controls. EFT thickness, CIMT, thyroid hormone levels and lipid parameters were measured in all subjects. Correlation analysis and linear regression analysis were performed for EFT thickness. Results Mean EFT thickness was 2.89 +/- 0.38, 3.53 +/- 0.92 and 4.56 +/- 1.61mm in control, SCH and OH groups, respectively (P < 0.001). EFT thickness of OH patients was high compared with SCH and control subjects (P < 0.01 and < 0.001, respectively). CIMT of OH patients was high compared with SCH and control subjects (P < 0.01 and < 0.001, respectively). In addition, EFT was significantly thicker in SCH patients than in controls (P < 0.05). Correlation analysis showed that EFT thickness was significantly positively correlated with CIMT, age, body mass index, systolic blood pressure, thyroid-stimulating hormone, total and LDL cholesterol and triglyceride and negatively correlated with free T4. In the regression analysis, EFT thickness retained its independent and positive association with CIMT, patient group (particularly OH) and systolic blood pressure. Conclusions Epicardial fat tissue thickness may be a useful indicator of early atherosclerosis in SCH and OH patients with HT.Öğe EVALUATION OF EPICARDIAL FAT TISSUE THICKNESS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM(Amer Assoc Clinical Endocrinologists, 2014) Asik, Mehmet; Sahin, Sinan; Temiz, Ahmet; Ozkaya, Mesut; Ozkul, Faruk; Sen, Hacer; Binnetoglu, EmineObjective: Primary hyperparathyroidism (pHPT) affects the cardiovascular system, and epicardial fat tissue (EFT) thickness is closely associated with cardiovascular diseases and atherosclerosis. Despite this, the association between EFT thickness and pHPT has not been studied in a clinical setting. This study aimed to assess EFT thickness in patients with pHPT. Methods: The study included 38 patients with pHPT and 40 healthy controls. EFT thickness, carotid intimamedia thickness (CIMT), serum levels of parathormone (PTH) and calcium, and blood chemistry profiles were determined in all subjects. Correlation and regression analyses were performed with EFT thickness and CIMT as dependent variables and age; systolic and diastolic blood pressure; body mass index (BMI); presence of diabetes mellitus; and free plasma glucose (FPG), PTH, and serum calcium (Ca) levels as independent variables. Results: Both the mean EFT thickness and the mean CIMT were significantly greater in the pHPT group than the control group (P<.001 for both). Correlation analysis showed that EFT thickness was significantly correlated with CIMT, age, systolic blood pressure, and PTH and serum Ca levels. Furthermore, the regression analysis revealed that EFT thickness retained its independent and positive association with FPG and serum Ca levels. Conclusions: The results of this study indicate that EFT thickness may be a useful marker of early atherosclerosis in patients with pHPT. Furthermore, the increase in EFT thickness appears to be due to hypercalcemia.Öğe Isolated Left Sided Diaphragmatic Injury Due to Blunt Trauma(Modestum Ltd, 2014) Ozkan, Omer Faruk; Ozkul, Faruk; Guner, Ali; Cekic, Arif Burak; Cagilci, AyhanDiafragmatic injury presents acutely and be associated with other life threatening injury of other organs. Sudden increase in abdominal pressure may cause injury in the membranous or muscular part of the diaphragm. While isolated diaphragmatic rupture after blunt trauma is rarely seen, its diagnosis can be overlooked frequently. Early diagnosis is the most important step in the treatment. Cases with delayed diagnosis can result in a diaphragmatic hernia with high mortality and morbidity rates due to complications such as strangulation and incarceration. The most critical point during the diagnosis is the suspicion for clinical diaphragm injury. X-ray graphy and computed tomography can be a guide for identifying diaphragmatic injuries. In this case report we presented an isolated left side diaphragmatic rupture after blunt abdominal trauma and treated with an urgent surgical operation.Öğe Laparoscopic Repair of Combined Right Diaphragm and Liver Injuries with a Sharp Object: A Case Report(Hindawi Ltd, 2013) Arik, M. Kasim; Tas, Sukru; Ozkul, Faruk; Sahin, Hasan; Karatag, Ozan; Karaayvaz, MuammerIntroduction. Diaphragm injuries develop following penetrating or blunt traumas. The purpose of the case report is to present a 28 year old male patient with stable hemodynamic findings treated with laparoscopic approach following a liver injury combined with a right diaphragm injury caused by a sharp penetrating object. Case. 4 cm long transverse laceration was observed near the middle axillary line in the 6th right intercostal space in the examination performed on a 28 year old male patient who applied to the emergency service due to sharp penetrating object injury. Respiratory sounds were decreased in the right side and the examination revealed sensitivity in the abdomen. Elevation in the right diaphragmand hemopneumothorax was monitored in chest X-ray and computerized tomography. Closed subaqueous thorax drain was placed and the patient was taken to the surgery with a right diaphragm injury prediagnosis. Laparoscopic exploration was performed to the patient with stable hemodynamic findings by entering through 10 mm port above the abdomen. 6 cm long injury at the right side of diaphragm and approximately 2 cm deep at the deepest point and 5 cm long linear laceration was observed in the 7th segment of the liver. The diaphragm was repaired laparoscopically with sutures that do not melt on their own. Tampon was applied to the laceration in the liver and bleeding control was performed with suture. Patient was discharged on the 3rd day because he had no problems during postoperative follow-ups. Result. No noticed right side diaphragm rupture and possible concomitant visceral organ injuries following a penetrant injury that can cause significant mortality and morbidity should be definitely kept in mind. The detection of right side diaphragm and liver injury is vital with high mortality in case of delayed diagnosis, and direct radiography and computerized tomography are helpful in the diagnosis. Surgical treatment with laparoscopic approach is a method that leads to less hospitalization duration and less pain in cases that are hemodynamically stable.Öğe Left ventricle ejection fraction may predict mortality in renal transplant patients(Taylor & Francis Ltd, 2016) Ozkul, Faruk; Arik, Muhammmet Kasim; Erbis, Halil; Akbas, Alpaslan; Yilmaz, Vural Taner; Barutcu, Ahmet; Osmanoglu, Ibrahim AliPurpose: Mortality is a major problem in renal transplant patients, and appropriate preoperative evaluation is very important. We retrospectively reviewed the left ventricle ejection fraction (LVEF) of renal transplant patients.Material and methods: The clinical records of 1763 patients who had preoperative LVEF results and who underwent renal transplantation at Akdeniz University Faculty of Medicine during the years 2004-2014 were studied. The LVEF limit was set at 55%. LVEF, age, gender, diabetes mellitus, hypertension, type of dialysis were assessed by linear multiple regression analysis on survival.Results: There were a total of 1763 renal transplant patients. Those with LVEF of <55% were identified as having left ventricular dysfunction. The mean LVEF was 59.49.1 in the 43 patients who died after renal transplantation, while it was 62.6 +/- 7.4 in the survivors (p=0.02). The mortality rate in the LVEF <55% group was 6.8% (11/162 patients), while mortality in the LVEF55% group was 2% (32/1601 patients, p<0.001). LVEF was found to be the most powerful variable on survival by the linear multiple regression analysis, R-2 = 0.05, p<0.001.Conclusion: LVEF may predict mortality in renal transplant patients. LVEF is known to be lower in patients with high cardiac mortality, who may require greater modifications of the postoperative risks.Öğe Perianal Giant Condyloma Acuminatum-Buschke-Lowenstein Tumor: A Case Report(Hindawi Ltd, 2012) Tas, Sukru; Arik, Muhammet Kasim; Ozkul, Faruk; Cikman, Oztekin; Akgun, YilmazCondyloma acuminatum caused by Human Papillomavirus is the most commonly occurring sexually transmitted infection in the anogenital region. Buschke-Lowenstein tumor (BLT) known also as giant condyloma acuminatum is a rare disease. The disease, for which the most important treatment method is the surgical excision, differs from normal condyloma acuminatum cases with its high degree of malignancy. The purpose of this paper is to present the case that reached huge dimensions in the perianal region and that was treated with wide resection in the literature.Öğe Serum ischemia modified albumin levels in subclinical cushing's syndrome(A. CARBONE Editore, 2016) Ozkul, Faruk; Turkon, Hakan; Cakir, Dilek Ulker; Eroglu, Mustafa; Tutunculer, Funda Kirtay; Faydaci, Umut; Ukinç, KubilayIntroduction: Subclinical Cushing's syndrome (SCS) is defined as biochemical overt cortisol excess in the absence of the classical signs and symptoms of Cushing's disease. The prevalence of SCS is reported as between approximately 5% and 24% in patients with adrenal incidentalomas (AI). SCS has increased cardiovascular and metabolic risk factors, and metabolic syndrome. Recently some studies demonstrated oxidative stress enhancement in Cushing's disease. Ischemia-modified albumin (IMA) is a marker of ischemia and oxidative stress and is increased in different clinical conditions such as cardiovascular diseases and metabolic syndrome. However, it has not been investigated in the patients with SCS. We aimed to evaluate serum IMA levels in the patients with SCS. Materials and methods: A total of 128 patients with AI were included in this study (17 patients with SCS and 111 patients with non-functional adenomas (NFA)). All patients were evaluated for the presence of adrenal masses using adrenal computed tomography (CT) scans. Serum IMA levels were measured by using a colorimetric method. Results: Serum IMA levels were significantly higher in SCS patients than in NFA patients (p < 0.05). Serum IMA was significantly correlated with waist circumference, low-density lipoprotein (LDL) levels and SCS. Furthermore, regression analysis revealed that serum IMA levels are independent and positively associated only with SCS. Conclusion: We concluded that elevated serum IMA levels might be accepted as a useful marker in patients with SCS. In order to reveal the pathological role of IMA levels in patients with SCS more studies are required.Öğe Severe hyperparathyroidism in patient with right thyroid hemiagenesis(Pakistan Medical Assoc, 2015) Eroglu, Mustafa; Ozkul, Faruk; Barutcu, Ebru Cakan; Arik, Kasim; Adam, Gurhan; Bilen, Yildiz; Ukinc, KubilayThyroid hemiagenesis is an infrequent congenital disorder which is rarely associated with hyperparathyroidism. We present a case of an adult woman who presented with hyperparathyroidism and ipsilateral thyroid hemiagenesis. Parathyroid adenoma was excised by minimal invasive parathyroidectomy.Öğe The effect of amifostine on bacterial translocation after radiation induced acute enteritis(Acta Cirurgica Brasileira, 2016) Tas, Sukru; Ozkul, Faruk; Arik, Muhammet Kasim; Kiraz, Asli; Vural, AhmetPURPOSE: To investigate the effects of amifostine on bacterial translocation and overgrowth in colonic flora after acute radiation enteritis in a rat model. METHODS: Thirty-two female Wistar albino rats were divided into four groups: Group-1 (n = 8): only normal saline was administered intraperitoneally. Group-2 (n = 8): first serum saline was administered intraperitoneally and 30 minutes later 20 Gy radiation was applied to abdominopelvic region. Group-3 (n = 8): only amifostine 200 ml/kg was administered intraperitoneally and radiation was not applied. Group-4 (n = 8): first amifostine 200 ml/kg was administered intraperitoneally and 30 minutes later 20 Gy radiation was applied to abdominopelvic region. On the 5th day after radiation, samples of mesenteric lymph tissues and cecal contents were taken by laparotomy for microbiological culture. RESULTS: Intraperitoneal amifostine administration significantly decreased the bacterial overgrowth related to radiation in colon but did not significantly decrease the bacterial translocation. CONCLUSION: Although not providing a full protection on the damaged mucosal barrier, amifostine significantly decreased the bacterial overgrowth in the cecal content after high dose radiation. There is a need to find out appropriate amifostine dose under different radiation applications avoiding bacterial translocation in gastrointestinal system.
