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Öğe A critical review of molecularly imprinted polymer technology for aflatoxin sensing: Current status and future directions(Elsevier, 2026) Cetinkaya, Ahmet; Kaya, S. Irem; Demirbakan, Burcak; Unal, Mehmet Altay; Sezginturk, Mustafa Kemal; Ozkan, Sibel A.; Altuntas, Evrim GunesSince the first discovery and identification of aflatoxins almost 70 years ago, their occurrence, potential risks, and health hazards remain of great importance. Therefore, several chromatography-, colorimetry-, and immunoassay-based analytical applications for aflatoxin detection are reported in the literature. Molecularly imprinted polymers (MIPs) have attracted considerable interest in sensor design due to their unique potential as synthetic recognition elements, providing high selectivity and excellent stability. These features help overcome the disadvantages of conventional sensing systems. The ongoing advancement of MIP-based sensors presents new opportunities for future applications and offers a reliable and versatile approach to meet the growing demands of current analytical research. This review focuses on studies published since 2023 concerning the detection of aflatoxins using MIP-based sensors, which hold a prominent and critical position in the literature. Additionally, this review addresses several limitations of MIP-based sensors, particularly in the context of aflatoxin detection, and discusses proposed solutions to overcome these challenges. Lastly, current advancements and future expectations in the topic are also highlighted.Öğe Bioprocess monitoring by biosensor-based technologies(Elsevier, 2020) Goker, Meric; Kurbanoglu, Sevinc; Huri, Pinar Yilgor; Sezgintürk, Mustafa Kemal; Ozkan, Sibel A.Today, biotechnological process applications are frequently used by an increasing importance in terms of industry and research. One of the natural consequences of scientific advances is the provision of more rapid progression by the effects on several scientific fields. Therefore, the rapid introduction of biotechnological processes into our daily lives leads to the development of new experimental tools (imaging methods and metabolic engineering), universal methods of analysis (genomics, proteomics, and metabolomics), and bioinformatics, which are able to respond rapidly to the needs and become more responsive. In this chapter, it is tried to define the bioprocess monitoring and analytical methods for bioprocesses with their measurement principles. Moreover, biologically varying sensors that are used in biomass monitoring and biomass concentration analysis are also defined. Turbidity sensors and impedance sensors, cell morphology analysis, in situ microscope systems, metabolic activity analysis, etc., are also stated. Current challenges with some novel examples are also shared. © 2020 Elsevier Inc. All rights reserved.Öğe Introduction to lateral flow assays(Elsevier, 2025) Yence, Merve; Burcu Aydın, Elif; Aydın, Muhammet; Kemal Sezgintürk, Mustafa Kemal; Ozkan, Sibel A.; Caglayan, Mehmet GokhanLateral flow assays (LFAs) use paper-based devices for analyte detection and quantification in complex mixtures. LFAs have garnered attention for their user-friendly forms, quick test times, minimal interferences, affordable prices, and ease of operation by nonexperts. This introduction chapter presents an overview of the working principle of this technique, its advantages, applications in many fields, components of the method, and some critical parameters for developing LFAs. © 2026 Elsevier Inc. All rights reserved..Öğe Lateral Flow Assays(Elsevier, 2025) Ozkan, Sibel A.; Kemal Sezgintürk, Mustafa KemalLateral Flow Assays: From Bench to Market provides a detailed understanding of lateral flow assays (LFAs), the technology behind them, and their potential uses. The book opens with a discussion of the key elements of LFAs before covering a range of different LFA types, including aptamer-based and SERS-based LFAs. Applications across the biosciences and beyond are explored, such as virus detection, including Covid-19, bacteria detection, hormonal detection, and cancer biomarkers. LFAs for the detection of narcotics, environmental pollutants, food additives, allergens, toxins, and metabolites are also explored. The book then discusses commercialization aspects of LFAs before looking to future developments. This book offers a complete overview of these biosensors and is an ideal reference for researchers and lab technicians across the biomedical sciences who work with these devices. It is also relevant to researchers and practitioners in food chemistry, the environmental industry, and pharmaceutical companies, in addition to those involved in the development of lateral flow devices. © 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies..Öğe Lateral flow assays for hormones(Elsevier, 2025) Cetinkaya, Ahmet; Kaya, S. Irem; Uludağ Anıl, İnci; Kemal Sezgintürk, Mustafa Kemal; Ozkan, Sibel A.Hormones are biological entities that are released by endocrine glands or tissues, and the critical metabolic and physiological pathways of the body require various hormones. Blood levels of hormones in an individual are important indicators of healthy or abnormal conditions. Accurate, rapid, and sensitive determination of the concentrations of hormones, which are usually at the picomolar-nanomolar level, is critical in health applications. In addition to this, it may also be possible to aim to increase efficiency and promote growth by adding steroid hormones to foods inappropriately. Detection of hormone residues in foods is also important to prevent situations that threaten food safety and human health. Lateral flow assays (LFAs) are advantageous, paper-based analysis platforms in which separation and selectivity features are integrated. LFAs are advantageous, paper-based analysis platforms in which separation and selectivity features are integrated. LFA design includes parts such as the bioreceptor, control zone, etc., and detection methods such as colorimetry or fluorescence can be used. In this chapter, the applications of LFAs in the health field for purposes such as diagnostics or monitoring of a condition and their use in food safety are examined. After giving information about the design of a standard LFA and the assay procedure, current studies containing the most important applications in hormone determination were evaluated in terms of target hormone, assay type, label, detection method used in LFA, linear range, limit of detection, examined sample, and recovery% value. While the current status of LFAs on a critical issue, such as hormone analysis, is discussed in detail, the future course is also evaluated. © 2026 Elsevier Inc. All rights reserved..Öğe Lateral flow assays for toxins, metabolites, and beyond(Elsevier, 2025) Aydın, Elif Burcu; Aydın, Muhammet; Kemal Sezgintürk, Mustafa Kemal; Ozkan, Sibel A.The most popular point-of-care biosensors for diagnostic, biomedical, food, agricultural, and environmental applications are lateral flow assays (LFAs). While the fundamentals of lateral flow assay technology date back several decades, newer nanomaterials have been employed as receptor attachment platforms or signal transducers, enhancing analytical capabilities. The recent development of LFAs illustrates their promising features, including their capacity to analyze several analytes and their speed, precision, dependability, and affordability for detecting toxins and metabolites. With their connection to smartphone technologies, they present an encouraging technological tool for point-of-care analysis, mobile medical services, and bioanalytical requirements. This chapter presents the LFAs for toxins and metabolites, investigates the construction protocol of LFAs, sensitivities and detection limits of LFAs, and limitations in complex sample applications. In addition, the challenges facing the next generation of LFAs and their commercialization are emphasized. Furthermore, this chapter will stimulate further study to create sophisticated, multifunctional, and integrated LFA for different applications. © 2026 Elsevier Inc. All rights reserved..Öğe Lateral flow assays in food analysis(Elsevier, 2025) Kaya, S. Irem; Cetinkaya, Ahmet; Kemal Sezgintürk, Mustafa Kemal; Ozkan, Sibel A.The intricacy of the global food systems has led to a focus on food safety and authentication, and food safety is a serious concern at every stage of manufacturing because foodborne microorganisms have a negative effect on human health. Furthermore, the presence of chemicals, drugs, heavy metals, microbial pathogens, mycotoxins, pesticides, and other potentially hazardous substances in food products poses a threat to food safety. Therefore, it is vital to develop a reliable and user-friendly tool to assess food quality. Traditional approaches to determining substances affecting seed safety in food analysis, like chromatographic techniques (high-performance liquid chromatography and gas chromatography), immunoassay techniques (enzyme-linked immunosorbent assay), polymerase chain reaction, mass spectrometry, and surface-enhanced Raman scattering are time-consuming, labor-intensive, and expensive, which makes them unsuitable for on-site use. The need for quick and easy methods for food safety has increased due to recurrent outbreaks of foodborne illness. Lateral flow assays (LFA) have gained popularity recently due to their on-site, low-cost, and quick pathogen detection capabilities. Here, recent advances in LFAs for detecting various food safety threats in food samples were examined, and the advantages and disadvantages of LFA performance were highlighted. In addition, the advantages and disadvantages of LFAs in food analysis, as well as future trends, will be discussed. The primary obstacles to the continued advancement of LFA platforms were explained, and LFAs could soon provide exceptional performance at the point of care that can compete with laboratory methods. © 2026 Elsevier Inc. All rights reserved..Öğe Lateral flow assays using aptamers(Elsevier, 2025) Özyurt, Canan; Demirbakan, Burçak; Özcan, Burcu; Uludağ Anıl, İnci; Kemal Sezgintürk, Mustafa Kemal; Ozkan, Sibel A.Aptamers, which are short single-stranded nucleic acids or peptides, have become versatile recognition elements as a result of their high specificity, stability, and cost-effectiveness. This chapter offers a thorough examination of aptamer-based lateral flow assays (LFA), with a particular emphasis on their principles, design strategies, and implications for environmental monitoring, food safety, and medical diagnostics. Aptamer-based systems provide superior chemical stability, an extended shelf life, and the ability to undergo a variety of modifications, in contrast to traditional antibody-based LFAs. This chapter also emphasizes the most recent developments in hybrid approaches that integrate aptamers with other biorecognition elements, signal amplification techniques, and aptamer selection methods. The novel concepts described in this chapter have the potential to facilitate the development of diagnostic instruments that are more cost-effective, portable, and efficient, and that have a broad range of applications in biosensor technology. © 2026 Elsevier Inc. All rights reserved..Öğe Sensitive voltammetric determination of famotidine in human urine and tablet dosage forms using an ultra trace graphite electrode(Serbian Chemical Soc, 2014) Yagmur, Sultan; Yilmaz, Selehattin; Saglikoglu, Gulsen; Uslu, Bengi; Sadikoglu, Murat; Ozkan, Sibel A.In this study, the direct and sensitive determination of famotidine based on its electrochemical oxidation was investigated in spiked human urine and tablet dosage forms. The electrochemical measurements were performed in various buffer solutions in the pH range 0.88-12.08 at an ultra trace graphite electrode (UTGE) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The best results were obtained for the quantitative determination of famotidine by the DPV technique in 0.5 mol L-1 H2SO4 solution (pH 0.30). In this strong acid medium, one irreversible anodic peak was observed. The effects of pH and scan rate on the peak current and peak potential were investigated. The diffusion-controlled nature of the peak was established. For optimum conditions described in the experimental section, a linear calibration curve for DPV analysis was constructed in the famotidine concentration range 2x10(-6)-9x10(-5) mol L-1. The limit of detection (LOD) and limit of quantification (LOQ) were 3.73x10(-7) and 1.24x10(-6) mol L-1 at a UTGE, respectively. The repeatability, precision and accuracy of the developed technique were checked by recovery studies in spiked urine and tablet dosage forms.
