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Öğe A rare reason of mechanical intestinal obstruction; phytobezoar images for clinicians(TIP ARASTIRMALARI DERNEGI, 2014) Cıkman, Oztekin; Ozkan, Omer Faruk; Adam, Gürhan; Tas, Sukru; Ademoglu, Serkan; Karaayvaz, MuammerMechanical intestinal obstruction is defined as the partial or total blockage of the passage of digested food in gastrointestinal system towards the distal. If intestinal obstruction is not treated properly it can cause high incidences of morbidity and mortality. The most frequent cause is adhesion after surgery but etiological cause changes frequently with age. Known symptoms of intestinal obstructions are nausea, vomiting, abdominal ache and distention in the abdomen. In our study we aimed to present a 70 year old patient with intestinal obstruction due to phytobezoar who developed sepsis, with the help of current literature. © 2014, TIP ARASTIRMALARI DERNEGI. All rights reserved.Öğe A Rare Reason of Mechanical Intestinal Obstruction; Phytobezoar Images for Clinicians(Modestum Ltd, 2014) Cikman, Oztekin; Ozkan, Omer Faruk; Adam, Gurhan; Tas, Sukru; Ademoglu, Serkan; Karaayvaz, MuammerMechanical intestinal obstruction is defined as the partial or total blockage of the passage of digested food in gastrointestinal system towards the distal. If intestinal obstruction is not treated properly it can cause high incidences of morbidity and mortality. The most frequent cause is adhesion after surgery but etiological cause changes frequently with age. Known symptoms of intestinal obstructions are nausea, vomiting, abdominal ache and distention in the abdomen. In our study we aimed to present a 70 year old patient with intestinal obstruction due to phytobezoar who developed sepsis, with the help of current literature.Öğe A Wandering Intravascular Scalpel Fragment After Lumbar Discectomy: A Case Report(Turkish Neurosurgical Soc, 2014) Aras, Adem Bozkurt; Ozkan, Omer Faruk; Alar, Timucin; Ozkan, Adile; Arik, M. Kasim; Kosar, Sule; Kirilmaz, BahadirVascular complications after lumbar discectomy are rarely seen. We present a unique and potentially life-threatening postoperative complication from this procedure. A 27-year-old man was admitted to our emergency vascular unit 1 day after a lumbar discectomy, during which a scalpel blade fragmented and a part was lost. Radiological images of the patient were performed and a broken scalpel blade was located anterior to the sacrum. An anterior laparotomy was performed which identified a mass within the left iliac vein that migrated suddenly to the inferior vena cava. An emergency angiography was performed, by which time the scalpel blade had ascended to the right-sided inferior pulmonary artery. It was subsequently removed via a right lateral thoracotomy.Öğe Agenesis of Isthmus of the Thyroid Gland in a Patient with Graves-Basedow Disease and a Solitary Nodule(Hindawi Ltd, 2013) Ozkan, Omer Faruk; Asik, Mehmet; Toman, Huseyin; Ozkul, Faruk; Cikman, Oztekin; Karaayvaz, MuammerThe thyroid is a vascular endocrine gland with two lateral lobes connected by a narrow, median isthmus. Although a wide range of congenital anomalies of the thyroid gland has been reported in the literature, agenesis of the thyroid isthmus is a very rare congenital anomaly Thyroid isthmus agenesis does not manifest clinical symptoms, and it can be confused with other thyroid pathologies. We describe a patient with no isthmus of the thyroid, associated with Graves-Basedow disease. Thyroid isthmus agenesis should be kept in mind in order for surgical procedures involving thyroid pathologies to be carried out safely.Öğe AN EXTREMELY RARE COMPLICATION OF MECKEL'S DIVERTICULUM: ENTEROCUTANEOUS FISTULIZATION OF UMBILICAL HERNIA(Colegio Brasileiro Cirurgia Digestiva-Cbcd, 2015) Cikman, Oztekin; Kiraz, Hasan Ali; Ozkan, Omer Faruk; Adam, Gurhan; Celik, Ahmet; Karaayvaz, Muammer[Anstract Not Available]Öğe Antioxidant Activity of Syringic Acid Prevents Oxidative Stress in L-arginine-Induced Acute Pancreatitis: An Experimental Study on Rats(Int College Of Surgeons, 2015) Cikman, Oztekin; Soylemez, Omer; Ozkan, Omer Faruk; Kiraz, Hasan Ali; Sayar, Ilyas; Ademoglu, Serkan; Taysi, SeyithanThe aim of this study was to investigate the possible protective role of antioxidant treatment with syringic acid (SA) on L-arginine-induced acute pancreatitis (AP) using biochemical and histopathologic approaches. A total of 30 rats were divided into 3 groups. The control group received normal saline intraperitoneally. The AP group was induced by 3.2 g/kg body weight L-arginine intraperitoneally, administered twice with an interval of 1 hour between administrations. The AP plus SA group, after having AP induced by 3.2 g/kg body weight L-arginine, was given SA (50 mg kg(-1)) in 2 parts within 24 hours. The rats were killed, and pancreatic tissue was removed and used in biochemical and histopathologic examinations. Compared with the control group, the mean pancreatic tissue total oxidant status level, oxidative stress index, and lipid hydroperoxide levels were significantly increased in the AP group, being 30.97 +/- 7.13 (P < 0.05), 1.76 +/- 0.34 (P < 0.0001), and 19.18 +/- 4.91 (P < 0.01), respectively. However, mean total antioxidant status and sulfhydryl group levels were significantly decreased in the AP group compared with the control group, being 1.765 +/- 0.21 (P < 0.0001) and 0.21 +/- 0.04 (P < 0.0001), respectively. SA reduces oxidative stress markers and has antioxidant effects. It also augments antioxidant capacity in L-arginine-induced acute toxicity of pancreas in rats.Öğe Combining Flexi-Seal and negative pressure wound therapy for wound management in Fournier's gangrene(Wiley, 2015) Ozkan, Omer Faruk; Altynly, Ediz; Koksal, Neset; Senger, Serkan; Celik, Atilla[Anstract Not Available]Öğe CYSTOGASTROSTOMY WITH ARGON PLASMA COAGULATION PROBE AND WITHOUT ENDOSCOPIC ULTRASONOGRAPHY(Colegio Brasileiro Cirurgia Digestiva-Cbcd, 2019) Ozkan, Omer Faruk; Akbal, Erdem; Tas, Sukru; Gunescystic, Fahri[Anstract Not Available]Öğe Diagnosing between papillary carcinoma and reactive papillary changes in an infarcted thyroid nodule after fine needle aspiration and accompanied by a synchronous brain stem astrocytoma(Kare Publ, 2018) Goret, Ceren Canbey; Goret, Nuri Emrah; Ozkan, Omer Faruk; Karaayvaz, MuammerA 22-year-old patient underwent fine needle aspiration of a nodule at the outer center of the right lobe of the thyroid, and it was reported to be Bethesda system category IV, Hurthle cell follicular neoplasia. The patient, who persented to Onsekiz Mart University Research and Application Hospital, underwent surgery. During right total thyroidectomy, an almost totally infarcted nodule and papillary structures around these infarcted areas were detected. Herein, we report on diagnostic challenges faced in confirming whether the infarcted nodule was a case of reactive papillary changes or an underdiagnosed papillary carcinoma and how the challenges were overcome using immunohistochemistry analysis and molecular genetic testing. In addition, we examined the case along with a literature review because an accompanying synchronous brain stem astrocytoma was detected in the patient after thyroidectomy.Öğe Effect of different doses of 2aEuroaminoethoxydiphenyl borate on intestinal ischemia-reperfusion injury(Springer Wien, 2017) Basbug, Murat; Yildar, Murat; Yaman, Ismail; Cavdar, Faruk; Ozkan, Omer Faruk; Aksit, Hasan; Ozyigit, Musa OzgurBackground Acute mesenteric ischemia is a life-threatening clinical entity. 2-Aminoethoxydiphenyl borate (2-APB) is a membrane-permeable modulator of intracellular inositol triphosphate-induced calcium release. We investigated the effects of different 2-APB doses on intestinal ischemia-reperfusion injury in an experimental rat model. Methods We divided 24 Wistar albino rats into four groups: sham, control, ischemia-reperfusion +2 mg/kg 2-APB, and ischemia-reperfusion +4 mg/kg 2-APB. The sham group only underwent laparotomy for 1 h 30 min. A 30-min period of mesenteric ischemia was induced in the control and two treatment groups, followed by 1 h of reperfusion. Before the laparotomy, 2 mg/kg and 4 mg/kg 2-APB was administered i.v. in the treatments groups, and blood samples were collected after reperfusion. Serum levels of malondialdehyde, superoxide dismutase, glutathione, total antioxidant capacity, tumor necrosis factor (TNF)-alpha, and interleukin-6 were analyzed. Intestinal tissues were taken for histopathological, DNA fragmentation, and terminal deoxynucleotidyl transferase dUTP nick end labeling analyses to determine the proportion of apoptotic cells. Results 2-APB reduced serum malondialdehyde, TNF-alpha, and interleukin-6 levels. However, superoxide dismutase and total antioxidant capacity levels increased significantly in the 4-mg/kg 2-APB group (p < 0.05). The intestinal histopathological injury scores were significantly higher in the control group; these injuries were prevented in the 4-mg/kg 2-APB dose group. DNA damage after ischemia-perfusion decreased significantly in the 4-mg/kg 2-APB group compared with the control group. Conclusion 2-APB decreases oxidative stress and cell injury. Administering 4 mg/kg 2-APB prevented ischemia-perfusion injury by diminishing histological damage.Öğe Effect of systemic carnitine therapy on serum fibronectin level in diabetic rats(Academic Press Inc Elsevier Science, 2014) Komurcu, Erkam; Ozkan, Omer Faruk; Kemik, Ahu Sarbay; Nusran, Gurdal; Asik, Mehmet; Arslan, EmrahBackground: L-carnitine has been shown to enhance wound healing. There has, however, not been sufficient research on the effect carnitine has on diabetic wound healing. We investigated the relationship between the viability of full thickness skin grafts (FTSGs) and fibronectin (FN) serum levels in diabetic rats that were administered carnitine. Materials and methods: A total of 40 rats were divided into four groups of 10 rats each and operated on. The FTSG model was 10 x 3 cm, with the dorsal flap extending from the tip of the scapula to the hip joint. After surgery, group 1 (nondiabetic control, n = 10) and group 2 (diabetic control, n = 10) were given a sterile saline solution at 0.9% with a dose of 100 mg/kg/d intraperitoneally for 7 d after the surgery. Group 3 (diabetic sham, n = 10) contained diabetic rats and did not receive any agent after the surgery. The diabetic rats in group 4 ( carnitine study diabetic, n 10) were given carnitine with a dose of 100 mg/kg/d intraperitoneally for 7 d after the surgery. Results: The percentages of viable areas in groups 1-4 were 70.38 +/- 6.10%, 62.66 +/- 1.55%, 62.59 +/- 2.94%, and 73.48 +/- 4.43%, respectively. The mean levels of FN, measured in milligram per deciliter, in groupse4 were 23.57 +/- 3.27 mg/dL, 21.58 +/- 2.35 mg/dL, 22.04 +/- 2.71 mg/dL, and 27.11 +/- 2.79 mg/dL, respectively. Furthermore, we found that there was a strong positive correlation (R = 0.509; P = 0.001) between FN and the viability of the FTSG. Conclusions: We demonstrated that administering carnitine leads to an increase in diabetic wound healing. Further increasing the levels of the FNserum might have a role in this process. Crown Copyright (c) 2014 Published by Elsevier Inc. All rights reserved.Öğe EFFECTS OF BORIC ACID IN AN EXPERIMENTAL RAT MODEL OF HEPATIC ISCHEMIA-REPERFUSION INJURY(Carbone Editore, 2015) Basbug, Murat; Yildar, Murat; Yaman, Ismail; Ozkan, Omer Faruk; Aksit, Hasan; Cavdar, Faruk; Sunay, Fatma BaharIntroduction: Hepatic ischemia-reperfusion injury can cause serious damages and affect distant organs. Boric acid is a antioxidant agent in ischemia/reperfusion injury. The aim of this study was to investigate the effects of boric acid in a rat model of hepatic ischemia-reperfusion injury. Material and methods: 30 rats were divided into three groups: sham, ischemia reperfusion and ischemia-reperfusion+boric acid. The sham group underwent only the surgical stress procedure. In the ischemia-reperfusion group, liver ischemia was induced by clamping the hepatic pedicle for 45 minute, followed by reperfusion for 1 hour. In the ischemia-reperfusion +boric acid group, the therapeutic agent boric acid was administered intraperitoneally, 10 minute before clamping the hepatic pedicle. Serum levels of malondialdehyde, superoxide dismutase, glutathione, total antioxidant capacity, tumor necrosis factor-alpha, interleukin-6, aspartate aminotransferase, alanine aminotransferase, Gamma-glutamyl transferase were determined. Liver tissues were taken for histopathological examination, DNA fragmentation, and TUNEL staining to determine the apoptotic index. Results: Boric acid moderately reduced serum levels of malondialdehyde, tumor necrosis factor-alpha, interleukin-6. aspartate aminotransferase, gamma-glutamyl transferase in the ischemia-reperfusion injury group. Superoxide dismutase and alanine aminotransferase levels were decreased significantly in the boric acid-administered group (P < 0.05). The histopathological injury scores and the rate of apoptosis were significantly higher in the ischemia-reperfusion group; these injuries were reduced by boric acid administration. Conclusion: Our results demonstrate that boric acid decreases lipid peroxidation and enhances the antioxidant defense mechanism. This study showed that boric acid might protect against ischemia-reperfusion injury in this rat model.Öğe ENDOSCOPIC REMOVAL OF AN UNUSUAL FOREIGN BODY FROM STOMACH: A WRISTWATCH(Colegio Brasileiro Cirurgia Digestiva-Cbcd, 2019) Ozkan, Omer Faruk; Tas, Sukru; Akbal, Erdem[Anstract Not Available]Öğe Intraoperative Endoscopic Retrograde Cholangiopancreatography in patients with complex benign biliary tract pathologies A case series(Edizioni Luigi Pozzi, 2018) Ozkan, Omer Faruk; Akbal, Erdem; Goret, Ceren Canbey; Goret, Nuri Emrah; Ozturk, Aydin; Cikman, Oztekin; Kocak, ErdemINTRODUCTION: This study presents data about the intraoperative performance of Endoscopic Retrograde Cholangiopancreatography (ERCP) for different types of cases with acute, complex pathologies of the biliary tract. MATERIALS AND METHODS: We retrospectively enrolled cases with intraoperative ERCP performed for different acute complex bile duct pathologies (including injury and cystic stump leak). All patients were analyzed according to demographic findings, etiologies, management and results. RESULTS: Intraoperative ERCP was performed in 4 patients of whom 2 (50%) were female and 2 (50%) were male with different diagnoses. The median age of patients was 468 (range of 28-75) years. The diagnosis was bile duct injury in three patients and one had a complicated hydatid cyst with jaundice (T Bil: 18 mg dl(-1)). All patients were in septic condition. Patients underwent laparotomy and intraoperative ERCP was performed successfully by using the Rendezvous technique. For the last patient, intraoperative ERCP was used for diagnosis and management of bile leak in the cavity. CONCLUSION: Intraoperative endoscopic retrograde cholangiopancreatography is a safe and effective method for treatment of acute complex bile duct pathologies.Öğe Isolated Left Sided Diaphragmatic Injury Due to Blunt Trauma(Modestum Ltd, 2014) Ozkan, Omer Faruk; Ozkul, Faruk; Guner, Ali; Cekic, Arif Burak; Cagilci, AyhanDiafragmatic injury presents acutely and be associated with other life threatening injury of other organs. Sudden increase in abdominal pressure may cause injury in the membranous or muscular part of the diaphragm. While isolated diaphragmatic rupture after blunt trauma is rarely seen, its diagnosis can be overlooked frequently. Early diagnosis is the most important step in the treatment. Cases with delayed diagnosis can result in a diaphragmatic hernia with high mortality and morbidity rates due to complications such as strangulation and incarceration. The most critical point during the diagnosis is the suspicion for clinical diaphragm injury. X-ray graphy and computed tomography can be a guide for identifying diaphragmatic injuries. In this case report we presented an isolated left side diaphragmatic rupture after blunt abdominal trauma and treated with an urgent surgical operation.Öğe L-carnitine has a protective effect on the colonic mucosa during abdominopelvic radiotherapy in rats(Acta Cirurgica Brasileira, 2016) Tas, Sukru; Ozkan, Omer Faruk; Cikman, Oztekin; Kiraz, Asli; Akgun, Yilmaz; Karaayvaz, MuammerPURPOSE: To evaluate histopathologically the radioprotective effect of L-carnitine on the colonic mucosa in rats undergoing abdominopelvic irradiation. METHODS: Thirty-two rats were randomly assigned to four experimental groups: intraperitoneal administration of normal saline (group 1) or L-carnitine (300 mL/kg; group 2), followed in groups 3 and 4, respectively, by one dose of abdominopelvic radiation (20 Gy) 30 min later. Rats were sacrificed 5 days after radiation, and their descending colons were resected for histopathological evaluation of the presence and severity of damage. RESULTS: Average damage scores did not differ significantly between groups 1 and 2 (0.13 +/- 0.35 and 0.25 +/- 0.46, respectively); the group 3 score was highest (10.25 +/- 0.71), and the group 4 score (3.63 +/- 1.41) was significantly lower than that of group 3 (both p = 0.0001). Pre-radiation L-carnitine administration significantly reduced mucosal thinning, crypt distortion, reactive atypia, inflammation, cryptitis, and reactive lymph-node hyperplasia (all p < 0.01). CONCLUSIONS: L-carnitine had a radioprotective effect on rat colonic mucosa. L-carnitine use should be explored for patients with gastrointestinal cancer, who have reduced serum L-carnitine levels.Öğe Limberg Flap Versus Bascom Cleft Lift Techniques for Sacrococcygeal Pilonidal Sinus: Prospective, Randomized Trial(Springer, 2013) Guner, Ali; Boz, Aydin; Ozkan, Omer Faruk; Ileli, Omer; Kece, Can; Reis, ErhanAlthough various methods have been described for surgical treatment of pilonidal sinus disease, which is best is under debate. Tension-free techniques seem to be most ideal. We aimed to evaluate the effects of two tension-free methods in terms of patient satisfaction, postoperative complications, and early recurrence. A group of 122 patients were prospectively included in the study. Patients were divided into two groups based on the operative method used: Limberg flap or Bascom cleft lift. Quality of life scores, pain scores, length of time for healing, hospital stay, surgical area-related complications, excised tissue weight, and early recurrence information were evaluated. Follow-up of patients in each group was completed. Patients in the Bascom cleft lift group had shorter operation duration, less excised tissue weight, better bodily pain score, and less role limitation due to physical problems score on postoperative day 10. There was no statistically significant difference between groups for the other criteria. Although both techniques provided good results during the early period, the Bascom cleft lift procedure is a reliable technique that provides shorter operation duration and better quality of life during the early postoperative period.Öğe MANAGEMENT OF FLAP DEHISCENCE AFTER LIMBERG PROCEDURE FOR RECURRENT PILONIDAL DISEASE BY NEGATIVE PRESSURE WOUND THERAPY (NPWT)(Colegio Brasileiro Cirurgia Digestiva-Cbcd, 2017) Tas, Sukru; Ozkan, Omer Faruk; Ocakli, Muzaffer Muazzez; Arslan, Emrah; Kiraz, Asli; Karaayvaz, Muammer[Anstract Not Available]Öğe Preoperative serum TNF-?, IL-6 and VEGF levels in patients with colorectal cancer(Elsevier Science Bv, 2017) Coskun, Ozlem; Oztopuz, Ozlem; Ozkan, Omer Faruk[Anstract Not Available]Öğe The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats(Acta Cirurgica Brasileira, 2018) Goret, Ceren Canbey; Goret, Nuri Emrah; Kiraz, Asli; Ozkan, Omer Faruk; Karaayvaz, MuammerPurpose: To investigate the effects of pycnogenol on peritoneal adhesions and additionally to investigate the immunohistochemical effects of free oxygen radicals and reactive lymph nodes detected in the adhesive tissue that was sampled surrounding the cecum on intra-abdominal adhesions. Methods: Twenty-seven Wistar Albino rats were divided into three groups. In group 1 (sham), laparotomy was performed and stitched up. In group 2 (control), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered 2 cc of saline. In group 3 (experimental), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered a sterile Pycnogenol derivative. The rats in all groups were re-laparotomized on postoperative day 7; samples were obtained from the peritoneal tissue surrounding the cecum, and the rats were sacrificed. Results: In group 3, there was a statistically significant difference in terms of inflammation, lymph node size, and free oxygen radicals; these parameters tended to increase. In terms of fibrosis evaluated using H&E and MT, there was no significant difference between groups 2 and 3. Conclusions: No positive outcomes indicating that pycnogenol reduces intra-abdominal adhesions were obtained. However, it caused severe inflammation in the tissue. Moreover, a significant increase in lymph node size was detected secondary to inflammation. Additionally, in immunohistochemical analyses conducted to detect oxidative stress, pycnogenol increased the production of free oxygen radicals in the tissue.
