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    Determination of IL-6, TNF-? and VEGF levels in the serums of patients with colorectal cancer
    (C M B Assoc, 2017) Coskun, O.; Oztopuz, O.; Ozkan, O. F.
    Cytokines are multifunctional polypeptides synthesized by different body cells. They have clinical significance in terms of disease diagnosis, treatment and prevention. Cytokines TNF-alpha and IL-6 play an important role in the growth and differentiation of cells. Vascular Endothelial Growth Factor (VEGF) is excessively produced in epithelial, mesenchymal, and particularly in tumor cells. Studies have shown that the increased serum concentrations of IL-6, TNF-alpha, VEGF are strongly associated with colorectal cancer and directly with the clinical stage of the disease. This can be used to diagnose cancer and to identify patients with a bad prognosis who can avail themselves of a more aggressive treatment. The present study investigated the role of cytokines in the development of cancer by comparing preoperative serum cytokine levels of patients suffering from colorectal cancer with those of the healthy control group. The prognostic significance of the data obtained has also been evaluated. For this purpose, IL-6, TNF-alpha and VEGF levels in 60 serums, 30 preoperatively taken from patients with colorectal cancer and 30 from a healthy control group at Canakkale Onsekiz Mart University General Surgery Clinic, were determined by ELISA kits. The statistical analyses of the obtained data were evaluated on SPSS, a statistical package program. In this study, no significant difference was obtained between the mean scores concerning the IL-6 and VEGF serums of the colorectal cancer and healthy group (p>.05). But a statistically significant decrease was observed in the TNF-a serum level of the colorectal cancer group in comparison with the control group (p= .016; p < .05).
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    Effects of Acute Pancreatitis on Plasma Total and Lipid Bound Sialic Acid Levels: An Experimental Study in Rats
    (Editura Celsius, 2014) Ozkan, O. F.; Cikman, O.; Roach, C.; Kemik, A. S.; Gunes, F.; Karaayvaz, M.
    Background: We investigated the relationship between serum levels of total sialic acid, lipid bound sialic acid and acute pancreatitis in a rat model of a common bile duct ligation induced acute pancreatitis. Methods: Twenty five Sprague-Dawley male rats weighing 250-300g were divided into two groups (n=10: control, n=15: experimental). In the control group only a sham laparotomy was performed. In the experimental group, acute pancreatitis was induced by common pancreatobiliary tract ligation. After 36 hours the rats were killed and amylase, serum total sialic acid, lipid bound sialic acid and lipid profiles were measured. Histopathological confirmation of acute pancreatitis was done using hematoxylin and eosin staining. Results: Mean amylase, total sialic acid (TSA) and lipid bound sialic acid (LBSA) measurements in the experimental group were significantly higher than in the control group. There was no significant difference in the lipid profiles between the two groups. Conclusion: Increased levels of TSA and LBSA can be useful as specific markers in the diagnosis of acute pancreatitis independent of serum lipid profile.
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    Evaluation of CR-POSSUM, Original ACPGBI and New ACPGBI Scoring Systems for Colorectal Cancer Surgery
    (Editura Celsius, 2014) Ozkan, O. F.; Guner, A.; Kaya, U.; Kece, C.; Reis, E.; Kesici, S.
    Purpose: To compare the Colorectal Physiological and Operative Score for enUmeration of Mortality and Morbidity (Cr-POSSUM) with the original Association of Coloproctology of Great Britain and Ireland (ACPGBI) and new ACPGBI scoring systems for their ability to predict mortality after colorectal cancer surgery. Methods: We retrospectively calculated the Cr-POSSUM,original ACPBGI and new ACPGBI scores of 105 patients who underwent colorectal cancer surgery. Data were obtained from patients' medical records and operative notes.Mortality was defined as death within 30 days of surgery.Scores were validated by assessing their calibration and discrimination. Calibration was assessed using the Hosmer-Leme show test and corresponding calibration curves. The discriminative capability of the models was evaluated using receiver operating characteristic (ROC) curve analysis. Results: The observed mortality rate was 4.8 %. The over all estimated risks of death of the Cr-POSSUM, original ACPGBI, and new ACPGBI scores were 9.92%, 7.35% and 4.20%, respectively. The results of areas under the curve(AUC) for Cr-POSSUM, original ACPGBI and new ACPGBI scores were 0.792, 0.844 and 0.801 respectively. Conclusions: The Cr-POSSUM, original ACPGBI and new ACPGBI scoring syStems are accurate in determining mortality rates and for predicting the risks of death in individual patients. The new and original ACPGBI scoring systems performed slightly better than the Cr-POSSUM scoring system.