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    Öğe
    Matrix metalloproteinase-2, tissue inhibitor of matrix metalloproteinase-2, and transforming growth factor beta 1 in the aqueous humor and serum of patients with pseudoexfoliation syndrome
    (Dove Medical Press Ltd, 2014) Kara, Selcuk; Yildirim, Nilgun; Ozer, Ahmet; Colak, Omer; Sahin, Afsun
    Purpose: The aim of the study reported in this article was to determine the presence and quantitative differences of matrix metalloproteinase-2 (MMP-2), its tissue inhibitor (TIMP-2) and transforming growth factor beta 1 (TGF-beta 1) in the aqueous humor and serum samples of patients with pseudoexfoliation (PEX) syndrome. Methods: Aqueous humor and serum samples were collected from 32 patients with PEX syndrome (with and without glaucoma) and a control group, who underwent routine cataract surgery. Levels of MMP-2, TIMP-2, and TGF-beta 1 were determined by specific immunoassays (enzyme-linked immunosorbent assay). Results: MMP-2, TIMP-2, and TGF-beta 1 were identified in aqueous humor and serum samples from all groups of patients. The aqueous and serum samples of MMP-2, TIMP-2, and TGF-beta 1 showed no significant differences between PEX syndrome and control groups. Serum levels of MMP-2, TIMP-2, and TGF-beta 1 were statistically greater than their aqueous levels (P<0.05), except for TIMP-2 levels in the control group. Conclusion: No statistically significant difference among mean MMP-2, TIMP-2, and TGF-beta 1 levels in both aqueous humor and serum samples was found between patients with PEX syndrome and the control group. It is important to simultaneously evaluate serum and aqueous samples from patients with PEX syndrome, which is related to an impaired blood-aqueous barrier.
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    Öğe
    Results of phaco surgery on the success of trabeculectomy in primary open-angle glaucoma patients with or without pseudoexfoliation
    (2025) Erdogan, Hakıka; Foroughifar, Shirin; Simsek, Tulay; Yildirim, Nilgun; Ozer, Ahmet
    Introduction: This study investigated whether trabeculectomy and phacoemulsification surgeries should be performed together or separately, focusing on how the timing and presence of phacoemulsification affect trabeculectomy success in open-angle glaucoma (OAG) patients, both with and without pseudoexfoliation (PEX). Methods: Patients were categorized into three groups: Group 1 underwent combined surgery, Group 2 had trabeculectomy alone, and Group 3 received phacoemulsification and trabeculectomy at separate times. Surgical success was defined as complete if IOP was 5–21 mmHg without medication, and partial if within the same range with medication. Results: The complete success rates for Groups 1, 2, and 3 were 38 (60.3%), 87 (58.4%), and 34 (49.3%), respectively, while partial success rates were 21 (33.3%), 29 (19.5%), and 17 (24.6%), respectively. Group 1 showed the highest overall success rate. The presence of PEX did not impact the success rates. Higher success was observed in patients with lower IOP both before and after surgery, whereas success rates were lower in groups that required needling. The presence of complications did not affect the success rates. Factors such as patient age, gender, type of surgery, number of preoperative medications, complications, and PEX status were not found to be associated with either complete or partial success during the follow-up period. Conclusions: Phacotrabeculectomy has been shown to achieve similar success rates to trabeculectomy, with the added benefit of allowing for earlier visual recovery.