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    The neuroprotective effect of fish n-3 fatty acids in the hippocampus of diabetic rats
    (Taylor & Francis Ltd, 2008) Cosar, Murat; Songur, Ahmet; Sahin, Onder; Uz, Efkan; Yilmaz, Ramazan; Yagmurca, Murat; Ozen, Oguz Aslan
    Introduction: Diabetes mellitus may lead to functional and structural changes in the brain. Fish oil is a rich source of n-3 essential fatty acids (EFA) such as eicosapentaenoic and docosahexoenoic acids. We examined the neuroprotective effects of fish n-3 EFA in the hippocampus of diabetic rats. Materials and methods: Nineteen adult male rats were divided into three groups. Group I ( control; n=6) was fed a normal rat diet. Group II ( diabetic; n=6) was fed a normal rat diet and streptozotocin (STZ) was administered to induce diabetes mellitus. Group III (n-3 + diabetic; n=7) was fed a normal rat diet and fish n-3 EFA (Marincap (R), 0.4 g/kg/day) for 8 weeks and STZ was administered to induce diabetes mellitus. The levels of malondialdehyde (MDA) and activities of superoxide dismutase ( SOD) and catalase ( CAT) were measured in the left hippocampus after the animals were sacrificed. The right hemisphere was completely blocked. The sections were stained with Cresyl Violet and apoptotic neurons were counted in the hippocampus. Results: The levels of MDA and activities of SOD and CAT increased in diabetic rats compared to control rats. However, the levels of MDA and activities of SOD and CAT decreased in n-3 + diabetic rats compared to diabetic rats. Also, the number of apoptotic neurons increased in diabetic rats compared to control rats and decreased in n-3 + diabetic rats compared to diabetic rats. Conclusions: Fish n-3 EFA reduces oxidative stress and induces apoptotic changes in the hippocampus of STZ-diabetic rats. The addition of fish n-3 EFA to diets may be useful to prevent functional and structural changes to cerebral centers due to diabetes mellitus.
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    Öğe
    The protective effect of fish n-3 fatty acids on cerebral ischemia in rat prefrontal cortex
    (Springer-Verlag Italia Srl, 2008) Ozen, Oguz Aslan; Cosar, Murat; Sahin, Onder; Fidan, Huseyin; Eser, Olcay; Mollaoglu, Hakan; Alkoc, Ozan
    This study presents neuroprotective effects of fish n-3 EFA on the prefrontal cortex after cerebral ischemia and reperfusion. Eighteen rats divided into three groups. Group A rats were used as control. Cerebral ischemia and reperfusion was produced in rats either on a standard diet (Group B) or a standard diet plus fish n-3 EFA for 14 days (Group C). The malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD) and catalase (CAT) were measured and the number of apoptotic neurons was counted. The levels of MDA and activities of SOD increased in Group B rats as compared to Group A rats, and decreased in Group C rats as compared to Group B rats. The activities of CAT increased in Group C as compared to Group B rats. The number of apoptotic neurons in the prefrontal cortex was lower in Group C as compared to Group B rats.