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    99mTc Radionuclide-labeled and hydrogel-coated BaTiO3 nanocomposites
    (Elsevier, 2024) Ekici, Sema; Ozdemir, Semra; Puren, Busra Aydur
    The current developments such as improving of radionuclides and drug carriers in nuclear medicine has been utilized for cancer diagnosis, prevention and treatment, in other words in theranostics. In radionuclide-based imaging, radionuclides can be conjugated to the nanoparticle and directed to the targeted tissue. Inorganic nanoparticles are capable of imaging and treatment of tumors and have demonstrated unique physicochemical and biological properties. In present study, m-BaTiO3 nanocomposites were prepared by coating biocompatible and nanosized BaTiO3 particles (tra-BaTiO3) with poly (3-acrylamidopropyl) trimethyl-ammonium chloride (pAPTMACl) ionic hydrogel. The prepared m-BaTiO3 nanocomposites were then modified with (TcO4-)-Tc-99m selected as radionuclide and 8-hydroxy-7-iodo-5-quinoline sulfonic acid (SQ) which is a drug used in the treatment of cancer, to form m-BaTiO3-(TcO4-)-Tc-99m and m-BaTiO3-SQ radiopharmaceutical nanocomposites, respectively. The characterizations of prepared nanoparticles were carried out with ATR-linked FT-IR and Raman spectroscopy, DLS, zeta potential, TEM, SEM, SEM-Element Mapping analyzes. Radiolabeling studies of m-BaTiO3 nano- composites were monitored with a radionuclide dose calibrator. The suspension stability of tra-BaTiO3 nano-particles was increased after the conjugation of (TcO4-)-Tc-99m and SQ molecules. Particle size values ranking found as; m-BaTiO3-(TcO4-)-Tc-99m < m-BaTiO3-SQ < m-BaTiO3 < tra-BaTiO3. Zeta potential values were measured as -9.80 +/- 1.12 mV,-7.54 +/- 4.46 mV, -21.30 +/- 0.32 mV, -25.60 +/- 0.35 mV for tra-BaTiO3 , m-BaTiO3 , m-BaTiO3-(TcO4-)-Tc-99m, m-BaTiO3-SQ, respectively. The amount of (99m) TcO4- attached to the tra-BaTiO3 nanoparticles increased threefold, after coating with the hydrogel. It was observed that 76 % of SQ drug molecules loaded onto m-BaTiO3-SQ nanocomposites was released within 10 h. Herein, we highlighted the design of BaTiO3 nano-particles with biocompatible and flexible pAPTMACl hydrogel, (99m) Tc radionuclide, and SQ cancer drug for using of radiopharmaceuticals in cancer imaging and radiotherapy in order to be a pioneer study for our researches in the future.
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    Alterations in Promoter Methylation Status of Tumor Suppressor HIC1, SFRP2, and DAPK1 Genes in Prostate Carcinomas
    (Mary Ann Liebert, Inc, 2012) Kilinc, Devran; Ozdemir, Oztuerk; Ozdemir, Semra; Korgali, Esat; Koksal, Binnur; Uslu, Atilla; Gultekin, Yener E.
    Hypermethylated genomic DNA is a common feature in tumoral tissues, although the prevalence of this modification remains poorly understood. We aimed to determine the frequency of five tumor suppressor (TS) genes in prostate cancer and the correlation between promoter hypermethylation of these genes and low and high grade of prostate carcinomas. A total of 30 prostate tumor specimens were investigated for promoter methylation status of TS hypermethylated in cancer 1 (HIC1), death-associated protein kinase 1 (DAPK1), secreted frizzled-related protein 2 (SFRP2), cyclin-dependent kinase inhibitor 2A (p16), and O-6-methylguanine-DNA methyltransferase (MGMT) genes by using bisulfite modifying method. A high frequency of promoter hypermethylation was found in HIC1 (70.9%), SFRP2 (58.3%), and DAPK1 (33.3%) genes in tumor samples that were examined. The current data show high frequency of hypermethylation changes in HIC1, SFRP2, and DAPK1 genes in prostate carcinomas of high Gleason Score (GS).
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    Assessment of Heart Rate Recovery with GATED-Myocardial Perfusion Scintigraphy Outcome in Patients with Coronary Artery Disease: A Retrospective Study and Institutional Experience
    (Galenos Yayincilik, 2016) Tan, Yusuf Ziya; Ozdemir, Semra; Altun, Burak; Celik, Fatmanur
    Objective: This study aimed to investigate the effects of assessment with myocardial perfusion scintigraphy (MPS) and heart rate recovery (HRrec) measurements in combination to evaluate the current status of patients with a diagnosis or suspicion of coronary artery disease (CAD). Methods: A total of 350 patients were included in the study. CAD group consisted of 200 patients with stable angina pectoris and a known history of CAD, while the control group consisted of 150 patients with suspicious stress test who had no history of known CAD. In order to calculate the HRrec index, the treadmill exercise test was performed in all patients according to the Bruce protocol. The MPS results were evaluated for the presence or absence of myocardial ischemia and infarction by visual and quantitative (summed stress score and summed difference score) assessments. Results: When the MPS results and HRrec were evaluated together, there was no statistically significant difference in the non-CAD group. But, when GATED-MPS was evaluated alone in the triple-vessel patient group, 27 (36%) patients were found to be normal while evaluated with HRrec, four (5.3%) patients were found to be normal. Conclusion: HRrec measurements obtained during stress MPS is important in patient evaluation. Therefore, evaluation of MPS results and HRrec measurements together may provide a more accurate estimation of possible presence of CAD in patients.
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    Assessment of the effects of frequent ventricular extrasystoles on the left ventricle using speckle tracking echocardiography in apparently normal hearts
    (Turkish Soc Cardiology, 2016) Barutcu, Ahmet; Bekler, Adem; Temiz, Ahmet; Kirilmaz, Bahadir; Gazi, Emine; Altun, Burak; Ozdemir, Semra
    Objective: Impairment in left ventricular (LV) function due to excessive ventricular extrasystoles (VESs) occurs during long-time follow-up. Speckle tracking echocardiography (STE) has been shown to be superior to conventional methods for evaluating cardiac functions. We aimed to use STE for early detection of LV dysfunction in patients with apparently normal hearts who have frequent VESs. Methods: Fifty-five patients with frequent VESs were identified according to the Lown classification (Grade 2; unifocal more than 30 times in 1 h). Subjects aged 22-60 years with frequent VESs that had been detected for at least 1 year were included in the study according to the inclusion criteria. Forty-five subjects with similar demographic characteristics, but without VESs, were included as the control group. All participants were evaluated by STE. Results: Fifty-five patients with frequent VESs (mean age 47 years, range 22-60 years; 42.2% male) and 45 control subjects (mean age 46 years, range 22-60 years; 37.8% male) were enrolled in the study. Global LV longitudinal strain (GLS) was decreased in patients with frequent VESs (-18.41 +/- 3.37 and -21.82 +/- 2.43; p<0.001). In addition, global LV circumferential strain was decreased in patients with frequent VESs (-16.83 +/- 6.06, -20.51 +/- 6.02; p<0.001). The frequency and exposure time of VESs were negatively correlated with GLS (r=-0.398, p<0.001; r=-0.191, p=0.001, respectively). Conclusion: STE revealed that LV functions were decreased in patients with VESs. This deterioration increased with the frequency and exposure time of VESs. Impairment of LV function due to excessive VESs occurs during long-time follow-up. STE may be used for early detection of LV dysfunction.
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    Association between ABCB1 (MDR1) Gene 3435 C>T Polymorphism and Colchicine Unresponsiveness of FMF Patients
    (Taylor & Francis Ltd, 2011) Ozen, Filiz; Silan, Coskun; Uludag, Ahmet; Candan, Ferhan; Silan, Fatma; Ozdemir, Semra; Atik, Sinem
    The multidrug resistance gene-1 (MDR1, adenosine triphosphate-binding cassette transporter: ABCB1, P-glycoprotein) encodes membrane proteins that play a crucial role in protecting cells from xenobiotics, chemicals, and drugs. The TT genotype of 3435 codon in exon 26 of MDR1 gene causes overexpression of gene activity and effluxes many chemically diverse compounds across the plasma membrane. We studied the association between C3435T polymorphisms (single nucleotide polymorphism) of MDR1 gene and colchicine-resistant familial Mediterranean fever (FMF) patients. Total genomic DNA samples from 52 FMF patients of colchicine unresponsiveness were used for FMF (MEFV) and MDR1 genes profile analyses. Target genes were genotyped by multiplex PCR-based reverse-hybridization Strip Assay method. The preliminary current results showed increased T allele frequency (0.596) in colchicine unresponsiveness of FMF patients. The distributions of the CC, CT, and TT genotypes in colchicine nonresponder FMF patients were 17%, 46%, and 37%, respectively. Our results indicate that C3435T polymorphism in exon 26 of MDR1 gene is associated with colchicine resistance in nonresponder FMF patients during the common therapy protocol.
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    Association Between ABCB1 (MDR1) Gene Polymorphism and Unresponsiveness Combined Therapy in Chronic Hepatitis C virus
    (Kowsar Publ, 2013) Timucin, Meryem; Alagozlu, Hakan; Ozdemir, Semra; Ozdemir, Ozturk
    Background: To treat viral infection of chronic hepatitis C (CHC) is a main strategy to prevent progression of liver disease, and cancer. Some patients with CHC have failed to respond to the common antiviral therapy in different populations. Objectives: In the current study it was aimed to find out the possible role of multiple drug resistance gene1 (MDR1) in non-responder patients with CHC infection in Turkish population. Patients and Methods: Peripheral blood-EDTA samples were used for total genomic DNA isolation. In total of 55 patients with chronic hepatitis C and positive results for genotype 1 [31 male (56.4%), 24 female (43.6%) and mean age-min-max; 56.9 +/- 9.66 (39-71)]; 19 responder (34.5%), 21 non responder (38.2%), and 15 recurrence (27.3%) were included in the presented results. Functional MDR1 gene was genotyped by multiplex PCR-based reverse-hybridization Strip Assay method, and some samples were confirmed by direct sequencing. Results: Our results indicate that MDR1 gene polymorphism is strongly associated with non-responder patients and those with recurrent chronic hepatitis C during conventional drug therapy when compared to the responder patients. Homozygous of the TT genotype for MDR1 exon 26 polymorphism was at 2.0-fold higher risk of non-responder than patients with CC and CT. Conclusions: The homozygous MDR1 3435TT genotype which encodes the xenobiotic transporter P-glycoprotein may be associated with a poor antiviral response in HCV chronicity during conventional therapy, and large-scale studies are needed to validate this association.
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    Comparison of fragmented QRS and myocardial perfusion-gated SPECT findings
    (Lippincott Williams & Wilkins, 2013) Ozdemir, Semra; Tan, Yusuf Ziya; Colkesen, Yuecel; Temiz, Ahmet; Turker, Fatmanur; Akgoz, Semra
    AimFragmented QRS (fQRS) complex is an ECG parameter that has recently been introduced and investigated. It is assumed that fQRS occurs because of disruptions in ventricular conduction due to ventricular infarction and ischemia. Therefore, in this article, we aimed to investigate the relationship between the detection of infarction and ischemia on myocardial perfusion-gated single-photon emission computed tomography images and appearance of fQRS on ECG.Materials and methodsWe retrospectively reviewed the records of patients with a diagnosis of coronary artery disease who were referred to our institution for myocardial perfusion scintigraphy. In total, 261 patients (122 women and 139 men, with a mean age of 6110.33 years) with and without fQRS (136 and 125, respectively) were included in the present study. The myocardial perfusion scintigraphy results were evaluated for the presence or absence of myocardial ischemia and infarction by visual and quantitative (summed stress score, summed rest, summed difference score, summed motion score, and summed thickening score) assessments. Statistical analysis was performed to determine the relationship between the presence of fQRS and myocardial ischemia and/or infarction. Student's t-test and the Mann-Whitney U-test were used for comparing the results. Pearson's (2)-test and Fisher's exact tests were also used to compare the distribution of variables between the two groups.ResultsThe prevalence of ischemia and infarction were found to be, respectively, 4.38-fold and 5.95-fold higher in patients with fQRS compared with the control group. Moreover, the prevalence of both ischemia and infarction was found to be 10.54-fold higher in patients with fQRS compared with the control group.ConclusionThere is a highly statistically significant possibility of detecting ischemia and infarction in perfusion myocardial scintigrams of patients whose ECGs have fQRS. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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    Confirmation of Brain Death with Positron Emission Tomography
    (Georg Thieme Verlag Kg, 2020) Ozdemir, Semra; Tan, Yusuf Ziya; Ozturk, Fulya Koc; Battal, Fatih
    After recent advances regarding organ transplantation, accurate and timely diagnosis of brain death has gained importance. In the diagnosis of brain death, in addition to clinical findings, various ancillary tests are very crucial. In this study, the scintigraphic imaging of the brain death of an 8-year-old girl with both Tc-99m diethylenetriaminepentaacetic and 18F-fluorodeoxyglucose (FDG) has been presented. This case study shows that 18F-FDG positron emission tomography-computed tomography imaging can be a useful technique in evaluating brain death in patients.
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    Diagnostic Performance of Machine Learning Models Based on 18F-FDG PET/CT Radiomic Features in the Classification of Solitary Pulmonary Nodules
    (Galenos Publ House, 2022) Salihoglu, Yavuz Sami; Erdemir, Rabiye Uslu; Puren, Busra Aydur; Ozdemir, Semra; Uyulan, Caglar; Erguzel, Turker Tekin; Tekin, Huseyin Ozan
    Objectives: This study aimed to evaluate the ability of (18)fluorine-fluorodeoxyglucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) radiomic features combined with machine learning methods to distinguish between benign and malignant solitary pulmonary nodules (SPN). Methods: Data of 48 patients with SPN detected on F-18-FDG PET/CT scan were evaluated retrospectively. The texture feature extraction from PET/CT images was performed using an open-source application (LIFEx). Deep learning and classical machine learning algorithms were used to build the models. Final diagnosis was confirmed by pathology and follow-up was accepted as the reference. The performances of the models were assessed by the following metrics: Sensitivity, specificity, accuracy, and area under the receiver operator characteristic curve (AUC). Results: The predictive models provided reasonable performance for the differential diagnosis of SPNs (AUCs similar to 0.81). The accuracy and AUC of the radiomic models were similar to the visual interpretation. However, when compared to the conventional evaluation, the sensitivity of the deep learning model (88% vs. 83%) and specificity of the classic learning model were higher (86% vs. 79%). Conclusion: Machine learning based on F-18-FDG PET/CT texture features can contribute to the conventional evaluation to distinguish between benign and malignant lung nodules.
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    Epigenetic silencing of the tumor suppressor HIC1 and SFRP2 genes in prostate carcinomas
    (Springer, 2011) Kilic, Davran; Ozdemir, Oziurk; Korgali, Esat; Ozdemir, Semra; Koksal, Binnur; Gultekin, Yener
    [Anstract Not Available]
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    Increased T allele frequency in MTHFR C677T gene in thyroid carcinoma
    (Springer, 2011) Ozdemir, Semra; Silan, Fatma; Erselcan, Taner; Uludag, Ahmet; Ustun, Funda; Colak, Ahmet; Atik, Sinem
    [Anstract Not Available]
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    Increased T-Allele Frequency of 677 C > T Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Differentiated Thyroid Carcinoma
    (Mary Ann Liebert, Inc, 2012) Ozdemir, Semra; Silan, Fatma; Hasbek, Zekiye; Uludag, Ahmet; Atik, Sinem; Erselcan, Taner; Ozdemir, Ozturk
    Background: Epigenetic alterations in the global DNA methylation status may be associated with an increased risk of some cancer types in humans. The methylenetetrahydrofolate reductase (MTHFR) gene is involved in folic acid metabolism and plays an essential role in inherited DNA methylation profiles. The common 677 C > T and 1298 A > C polymorphisms in the MTHFR gene cause the production of a thermolabile enzyme with reduced function and, eventually, genomic DNA hypomethylation. The current preliminary study was designed to determine the association between germ-line polymorphism in the MTHFR gene and differentiated thyroid carcinoma (DTC). Methods: In the current case-control study of 60 thyroid carcinomas (TC); 45 papillary TC, 9 follicular TC, and 6 DTC of an uncertain malignant potential were examined. Genomic DNA was extracted from peripheral blood with EDTA, genotyped by a multiplex real-time polymerase chain reaction. Results: An elevated 2.33-fold risk was observed for DTC in individuals with the 677TT genotype when compared with the control group (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.03-3.58). Current DTC patients showed similar results as a control group for the 1298 A > C allele. No significant risk was detected for the homozygous 1298CC genotype (CC vs. AA or AC) (OR: 1.30, 95% CI: 0.73-2.29). Conclusion: The current results are supportive of the hypothesis that the homozygous MTHFR 677TT genotype increases the risk factor of developing thyroid cancer, and further large-scale studies are needed to validate this association.
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    Myocardial Perfusion Spect Imaging in Dextrocardia: A Case Report
    (Galenos Yayincilik, 2013) Ozdemir, Semra; Gazi, Emine
    The myocardial perfusion scintigraphy acquisition and analysis present some technical differences in the rare dextrocardia cases. Here we report a case of a 38 year-old woman with dextrocardia who had been applied myocardial perfusion scintigraphy. Presented case showed that the thoracic and abdominal organs had a mirror image with situs inversus totalis type dextrocardia. The incidence of coronary heart disease and life span of people with situs inversus totalis are the same as the normal population. So we may apply myocardial perfusion scintigraphy to this patient group. The current case is presented in order to remind the special applications of myocardial perfusion SPECT imaging in patients with dextrocardia.
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    Possible Roles of the Xenobiotic Transporter P-glycoproteins Encoded by the MDR1 3435 C>T Gene Polymorphism in Differentiated Thyroid Cancers
    (Asian Pacific Organization Cancer Prevention, 2013) Ozdemir, Semra; Uludag, Ahmet; Silan, Fatma; Atik, Sinem Yalcintepe; Turgut, Bulent; Ozdemir, Ozturk
    Background: P-glycoprotein (Pgp), encoded by the multidrug resistance 1 (MDR1) gene, is an efflux transporter which plays an important role in pharmacokinetics. The current preliminary study was designed to determine associations between a germ-line polymorphism in the MDR1 gene with differentiated thyroid carcinoma (DTC). Materials and Methods: In the current case-control study, 60 differentiated thyroid cancers (DTC)- 45 papillary TC (PTC), 9 follicular TC(FTC) and 6 well-differentiated tumors of uncertain malignant potential (WDT-UMP) were examined. Results were compared to a healthy control group (n=58) from the same population. Genomic DNA was extracted from peripheral blood with EDTA and the target gene was genotyped by real-time PCR. Results: Carriers of the variant allele of MDR1 exon 26 polymorphism were at 2.8-fold higher risk of DTC than the control group (odds ratio [OR]: 0.3805, 95% confidence interval [Cl]: 0.1597-0.9065 (p>0.046). Conclusions: Presented results suggest that the MDR1 3435TT genotype might influence risk of development of DTC and that the CC genotype might be linked to a poor prognosis. Large-scale studies are now needed to validate this association.
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    Predictors of Hypothyroidism Following Empirical Dose Radioiodine in Toxic Thyroid Nodules: Real-Life Experience
    (Elsevier Inc, 2022) Demir, Busra Kuyumcu; Karakilic, Ersen; Saygili, Emre Sedar; Araci, Nilgun; Ozdemir, Semra
    Objective: We aimed to determine the factors predicting hypothyroidism after radioactive iodine (RAI) treatment in patients with toxic adenoma and toxic multinodular goiter.Methods: We retrospectively collected the data of 237 patients with toxic multinodular goiter or toxic adenoma who had consecutively received RAI treatment between 2014 and 2020 at 2 medical centers. Patients who received the second RAI treatment and whose medical records could not be accessed were excluded from the study. Finally, 133 patients were included in the study. RAI was administered at an empirical dose of 15 or 20 mCi.Results: The median age of the 133 participants was 69 years (interquartile range, 62-75 years), and 64.7% of the participants were women. A total of 42.1% of the patients had toxic adenoma, whereas 57.9% of patients had toxic multinodular goiter. The median follow-up was 24 months (interquartile range, 11-38 months). During the follow-up, 61.7% of patients became euthyroid, 30.8% developed hypothy-roidism, and 7.5% remained hyperthyroid. The median month of hypothyroidism onset was 4 months (interquartile range, 2-9 months). Regression analysis revealed 2 factors that could predict hypothy-roidism: thyroid-stimulating hormone (odds ratio, 2.548; 95% CI, 1.042-6.231; P = .04) and thyroid volume (odds ratio, 0.930; 95% CI, 0.885-0.978; P = .005).Conclusion: Overall, 30.8% of the cases developed hypothyroidism after the RAI treatment. Approxi-mately 78% of hypothyroidism developed within the first 10 months. The risk of hypothyroidism was higher in patients with higher thyroid-stimulating hormone and smaller thyroid volume.(c) 2022 AACE. Published by Elsevier Inc. All rights reserved.
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    Prognostic value of free/total PSA ratio in prediction of bone metastases in patient with prostate cancer
    (Elsevier Science Bv, 2018) Ozdemir, Semra; Tan, Yusuf Ziya; Ersay, Ahmet Resit; Ozturk, Fulya Koc; Ozdemir, Beril Su
    [Anstract Not Available]
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    Relationship between fragmented QRS and paradoxical septal motion in coronary artery bypass graft patients
    (Springer, 2015) Barutcu, Ahmet; Ozdemir, Semra; Tan, Yusuf Ziya; Yener, Ali Umit; Ozcan, Sedat; Gazi, Emine
    Paradoxical septal motion (PSM) can cause confusion in the assessment of ventricular function with scintigraphy even in the absence of ventricular septal damage and ischemia. Fragmented QRS (fQRS) is associated with various cardiac disorders. In this study, we aimed to determine the correlation between paradoxical septal motion and fQRS after coronary artery bypass grafting (CABG). We retrospectively reviewed the hospital records showing scintigraphic images and electrocardiograms (ECG) of the patients who had undergone CABG. The patients were classified based on the evaluation of motion and thickening of the septal wall. The patients with regular thickening of the septal wall and abnormal motion were classified as PSM (+) group. The patients with normal motion and thickening of the septal wall were classified as PSM (-) group. fQRS complexes are defined as various RSR patterns either with or without Q-waves on a 12-lead resting ECG. PSM was found to be more common in fQRS patients (p < 0.001). PSM was seen in 91.4 % of cases with fQRS and in 79.8 % of cases without fQRS. No significant differences were found in the phase analysis parameters. A correlation was found between septal wall motion values and the presence of fQRS (r = 0.197, p = 0.012). fQRS was associated with PSM. fQRS may cause PSM in patients with CABG without left bundle branch block due to a conduction defect. PSM and fQRS are predictive of cardiac mortality. Patients diagnosed with PSM and fQRS, should be monitored closely.
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    Risk stratification using gated stress myocardial perfusion imaging: comparison between patients with and without sexual dysfunction
    (Bmj Publishing Group, 2016) Tan, Yusuf Ziya; Ozdemir, Semra; Bekler, Adem; Akbas, Alpaslan; Gencer, Meryem; Celik, Fatmanur
    Sexuality is an indispensable part of life. When a problem is encountered related to this topic, the quality of life is negatively affected. Therefore, every problem related to sexuality is extremely private and important to an individual. This study aims to investigate the use of myocardial perfusion scintigraphy (MPS) for advanced assessment of patients with known or suspected coronary artery disease, cardiovascular disease, and in the intermediate risk group for SD. The study included 250 patients (150 male, 100 female, mean age 54 +/- 12.10) sent by the Cardiology Clinic to the Nuclear Medicine Clinic for MPS due to suspected cardiovascular disease (CVD). The questionnaire study was applied by two methods as face-to-face interviews or online. Data on sociodemographic characteristics and cardiovascular diseases together with risk factors for sexual activity were collected using a general information form. Patients were divided into three categories of risk depending on major risk factors for cardiovascular diseases: low, intermediate, and high risk. On comparing the risk scores between the groups, it was seen that there was a statistically clear reduction in the intermediate risk group of patients with SD according to MPS scoring. MPS is a cost-effective, reliable, and accurate non-invasive diagnostic method necessary for routine use to assess cardiovascular disease and in the intermediate risk group for SD.
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    The assessment of septal wall motion in patients undergoing CABG by myocardial perfusion-gated SPECT
    (Lippincott Williams & Wilkins, 2015) Ozdemir, Semra; Yener, Ali Umit; Barutcu, Ahmet; Tan, Yusuf Z.; Celik, Fatmanur
    PurposeIn this study, we aimed to assess the presence and prevalence of paradoxical septal motion (PSM) by myocardial perfusion-gated single-photon emission computed tomography (SPECT) imaging in patients undergoing coronary artery bypass grafting (CABG).MethodsA total of 172 patients (145 men and 27 women, with a mean age of 64.818.93 years) undergoing CABG surgery were included in the study. All selected scintigraphic studies of the patients undergoing CABG were reprocessed. Semiquantitative interpretation of septal perfusion, wall motion, and wall thickening was performed with QPS and QGS programs. Phase analysis parameters were also obtained using the Emory Cardiac Toolbox. According to myocardial perfusion-gated SPECT results, the patients were trichotomized as follows: group 1 (nonischemic PSM): regular perfusion and thickening of the septal wall and abnormal motion of the septal wall; group 2 (ischemic PSM): abnormal perfusion, motion, and thickening of the septal wall; group 3 (non-PSM): normal perfusion, motion, and thickening of the septal wall. The data in each of the three groups were compared using Student's t-test and one-way analysis of variance.ResultsNo PSM (normal perfusion, motion, and thickening of the septal wall) was observed in 19.2% of patients undergoing CABG, whereas nonischemic PSM (regular perfusion and thickening of the septal wall and abnormal motion of the septal wall) was observed in 60.5% of patients and ischemic PSM (abnormal perfusion, motion and thickening of the septal wall) was seen in 20.3% of patients.ConclusionAccording to our study results, PSM is fairly common in patients undergoing CABG. It will be beneficial to use myocardial perfusion scintigraphy-gated SPECT, which is a noninvasive examination method, to identify the presence of PSM and investigate whether it is accompanied by ischemia or infarction.
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    The effect of relaxing music on heart rate and heart rate variability during ECG GATED-myocardial perfusion scintigraphy
    (Elsevier Sci Ltd, 2015) Tan, Yusuf Ziya; Ozdemir, Semra; Temiz, Ahmet; Celik, Fatmanur
    Background: The positive changes in human behavior caused by relaxing music demonstrate the psychological effect of music on human body. A meta-analytical study has shown that relaxing music affects blood pressure and heart rate in coronary heart patients and cancer patients. The aim of our study is to research whether there is a significant effect on heart rate and heart rate variability due to listening to relaxing music during ECG GATED MPS imaging under gamma camera. Method: The music group (n = 50 patients) could choose from 15 different musical types including folk music (no lyric). The other 50 patients were placed in a no music group and did not get headphones or any music. Results: There was a statistically significant reduction in the heart rate of patients in the music group compared to those in the control group. Conclusions: Relaxing music provides great benefits to both patient and clinician. There is close relationship between relaxing music and health procedure, can use every area of the health noninvasiv, safe, cheap and is a method don't have side effect. (C) 2015 Elsevier Ltd. All rights reserved.