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    Resistance Rates of Antituberculosis Drugs in Pulmonary Tuberculosis Patients Producing Mycobacterium Tuberculosis
    (Aves, 2011) Perincek, Gokhan; Tabakoglu, Erhan; Otkun, Metin; Ozdemir, Levent; Ozdemir, Burcu
    Objective: Determination of antituberculosis drug resistance rate in pulmonary tuberculosis patients producing Mycobacterium tuberculosis. Material and Method: 134 pulmonary tuberculosis patients producing Mycobacterium tuberculosis in cultures in the Trakya University Medical Faculty Hospital between the years 2005-2007 were enrolled in the study. Four major antituberculosis drugs (H, R, streptomycin (SM), ethambutol (EMB)) resistance and multidrug resistance rates were investigated. using the BACTEC 460 TB system. Results: 134 pulmonary tuberculosis patients producing Mycobacterium tuberculosis were detected and 31 female patients were found and 103 male patients. Acid resistant bacilli were found in 58.2% of the patients with EZN. Antituberculosis resistance rates were established as H 10.4%, R 3%, EMB 0.7%, SM 0.7%. Conclusion: It was determined that a follow up of drug resistance patterns in patients with pulmonary tuberculosis will be useful in determining treatment protocols and preventing drug resistance.
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    The Change of Antituberculosis Drug Resistance Rate in Edirne Region in 1996 and 2006
    (Wolters Kluwer Medknow Publications, 2010) Perincek, Gokhan; Tabakoglu, Erhan; Otkun, Metin; Ozdemir, Levent
    Objective: To establish the change in the ratio of the a ntituherculosis drug resistance in Edirne region between 1996-2006. Materials and Methods: The patients, who were detected with Mycobacterium tuberculosis proliferation in the cultures, were enrolled to the study between 1996-2006. The patients, who were diagnosed with isoniazid, rifampisin, ethambutol, streptomycin and multi-drug resistance were selected and their data of was uploaded to SPSS software in order to perform statistical analysis. Results: We found the Mycobacterium tuberculosis proliferation of cultures in 70 patients in 1996, whew. 21 patients had isoniazid, 8 patients had rifampicin, 7 patients had ethambutol, r patients had streptomycin, and 5 patients had multi Burg resistance. En 2006, illyrobacterium tuberculosis proliferation was established in 47 patients. Of these, 11 patients had isoniazid, 8 had rifampisin, one patient had ethambutol, 2 patients had streptomycin and 3 patients had multi-durg resistance. We compared the changes in the resistance figures and found a decrease: of drug resistance as follows: in isoniazid, from 21 patients (301Y0) to 11 patients (23.4%); in rifampisin, from 8 patients (11%) to 4 patients (8.5%0; in ethambutol, from 7 patients (13'Yo) to one patient (2.1`,0; in streptomycin, from r patients (39%) to 2 patients (4.3%); in multi drug, from 5 patients (7%) to 3 patients (6.4`%). Conclusion: Although statistically significant decrease of drug resistance was not found in isoniazid, rifampisin, ethambutol and multi-drug, a significant drug resistance \vas estabished in streptomycin in Edirne region during the 10 years period.