Yazar "Oroojalian, Fatemeh" seçeneğine göre listele

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    A novel approach to glioblastoma multiforme treatment using modulation of key pathways by naturally occurring small molecules
    (Springer Basel Ag, 2025) Afshari, Amir R.; Sanati, Mehdi; Aminyavari, Samaneh; Keshavarzi, Zakieh; Ahmadi, Seyed Sajad; Oroojalian, Fatemeh; Karav, Sercan
    Glioblastoma multiforme (GBM), the fatal primary brain malignancy in adults, represents significant health challenges, and its eradication has been the ultimate goal of numerous medical investigations. GBM therapy encompasses various interventions, e.g., chemotherapy by synthetic cytotoxic agents like temozolomide (TMZ), radiotherapy, and, more recently, immunotherapy. A notable focus has been on incorporating naturally occurring substances in treating malignancies. Polyphenols and terpenoids, widely present in fruits and vegetables, constitute primary categories of agents employed for this purpose. They pose direct and indirect impacts on tumor growth and chemoresistance, mainly through impacting the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling, crucial in cellular processes, metabolism, and programmed death. This paper thoroughly discusses the biologic effects and practical application of polyphenols and terpenoids on GBM through the PI3K/Akt/mTOR signaling in vitro and in vivo.
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    Nano-phytoconstituents: Recent advances, regulatory insights, challenges, and future horizons
    (Elsevier, 2025) Beygi, Mohammad; Oroojalian, Fatemeh; Karav, Sercan; Kesharwani, Prashant; Sahebkar, Amirhossein
    Phytoconstituents possess therapeutic potency in human diseases, including antioxidant, antitumor, antiinflammatory, and anti-microbial impacts, as well as cardioprotective and neuroprotective capabilities. Nonetheless, they suffer from shortcomings like low solubility and bioavailability, fast degradation upon administration, and elevated doses required to exert therapeutic effects, culminating in potential adverse effects. As a solution to these, nanoscale drug delivery systems (DDSs) such as polymeric nanoparticles (NPs), lipid-based NPs, protein-based NPs, etc. are currently devised to realize intended goals in herbal medicine, which critically are sustained release and targeted delivery of phytomedicines to affected sites. Current DDSs are formulated to encapsulate diverse phytochemicals, including curcumin, berberine, resveratrol, quercetin, baicalin, and rosmarinic acid. The ultimate nanoassembly affords superior properties such as protracted circulation time, sustained release, site-specific delivery, synergistic effects (with antitumor agents), and measurable diseasealleviating effects. This article covers recent progress in nanophytomedicines and explores how DDSs can enrich the therapeutic properties of these phytochemicals. Further, the present article covers the regulatory aspects and ethical issues to be reflected when devising such DDSs, as well as the current standing of nanophytoconstituents in clinical trials.
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    Targeted delivery of phytochemicals via nanocarriers: Emerging strategies for psoriasis and acne
    (Elsevier, 2026) Darbandy, Zahra Jalayeri; Oroojalian, Fatemeh; Kesharwani, Prashant; Karav, Sercan; Sahebkar, Amirhossein
    Psoriasis and acne are prevalent dermatological disorders often managed with conventional therapies, which present limitations in efficacy, safety, and long-term outcomes. Recently, increasing attention has been directed toward the integration of phytoconstituents, bioactive compounds derived from medicinal plants, into nanocarrier-based drug delivery systems as a novel therapeutic strategy. Phytochemicals possess well-documented antioxidant, anti-inflammatory, and wound-healing properties, and generally offer favorable a safety profile compared to synthetic agents. Incorporated of these natural compounds into nanocarriers enhances their therapeutic potential by improving skin penetration, enabling controlled drug release, facilitating targeted delivery, and reducing dosing frequency. This review highlights recent advances in the use of nanotechnology to optimize the delivery and efficacy of phytoconstituents for treating psoriasis and acne. It also discusses the mechanistic insights, therapeutic outcomes, formulation challenges, and translational hurdles associated with the clinical application of these nano-herbal systems. Continued research and development are essential to address formulation stability, scaling processes, regulatory compliance, and clinical validation, thereby facilitating the commercialization of effective and safe phyto-nanocarrier therapies in dermatology