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    Evaluation of the potential roles of activin-A, activin-B, and follistatin molecules exhibiting immunomodulatory properties in brucellosis
    (Wiley, 2021) Kızmaz, Muhammed Ali; Ellergezen, Pinar Hiz; Demir, Nesrin; Çağan, Eren; Akalın, Emin Halis; Oral, Haluk Barbaros; Budak, Ferah
    Brucellosis is a zoonotic disease caused by bacteria called Brucella. The mechanisms underlying the changes seen in the course of brucellosis are not adequately elucidated. It was aimed to reveal the potential roles of activin‐A, activin‐B, and follistatin molecules in sera taken from patients with acute and chronic brucellosis, healthy controls, and recovered individuals to overcome these deficiencies. Activins are members of the transforming growth factor‐1 (TGF‐β1) superfamily. Activin‐A has been shown to play a role in both pro‐ inflammatory and anti‐inflammatory processes. Follistatin is a protein that inhibits or neutralizes the functions of activins, and in this way, it can regulate the inflammatory process.
  • Küçük Resim
    Öğe
    Potential effects of sCD40L, CD36, IL-23 and arginase-1 molecules on the pathogenesis of brucellosis
    (Wiley, 2021) Kızmaz, Muhammed Ali; Ellergezen, Pınar Hız; Demir, Nesrin; Cagan, Eren; Çolak, Zehranur; Akalın, Emin Halis; Oral, Haluk Barbaros; Budak, Ferah
    Brucellosis is a systemic infectious disease that can be transmitted from animals to humans, ranging from mild to severe clinical pictures. In our study, we aimed to reveal the roles of sCD40L, CD36, IL‐23 and arginase‐1 (ARG1) molecules in the pathogenesis of brucellosis. sCD40L binds and activates CD40 on antigen‐presenting cells, thereby promoting the secretion of pro‐inflammatory cytokines and nitric oxide (NO) synthesis.