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    Evaluation of Serum Creatinine Levels with Reference Change Value in Patients Receiving Colistin Treatment
    (Oxford University Press, 2023) Cinpolat, Havva Yasemin; Alkan, Sevil; Altinisik, Hatice Betul; Cakir, Dilek Ulker; Oguzman, Hamdi
    Objective: In this study, we aimed to evaluate the serum creatinine (SCr) levels with the reference change value (RCV) in patients receiving colistin treatment. Methods: We retrospectively recorded the SCr levels of 47 patients receiving colistin treatment before treatment and on days 3 and 7 after treatment. RCV was calculated with the asymmetrical RCV formula (Z = 1.64, P <. 05). Percent (%) increase in the SCr results of the patients was compared with RCV and values exceeding RCV were regarded as statistically significant. Results: The RCV was calculated as 15.6% for SCr. Compared with pretreatment values, SCr value on day 3 was 32/47 and on day 7 it was 36/47; as these results exceeded RCV, they were considered statistically significant. Conclusion: Use of RCV in the interpretation of results between serial measurements will provide a more rapid and sensitive method when making decisions. © 2023 The Author(s).