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    C-reactive protein gene and Toll-like receptor 4 gene polymorphisms can relate to the development of psoriatic arthritis
    (Springer London Ltd, 2015) Akbal, Ayla; Oguz, Sevilay; Gokmen, Ferhat; Bilim, Serhat; Resorlu, Hatice; Sılan, Fatma; Uludağ, Ahmet
    We aimed to determine in psoriatic arthritis (PsA) patients the Toll-like receptor (TLR) 4 and C-reactive gene (CRP) polymorphisms and allele frequency and to investigate the relationship between clinical parameters and gene polymorphisms. We enrolled in this study 31 PsA and 41 healthy control subjects. PsA diagnosis was according to CASPAR criteria. Bath ankylosing spondylitis diseases activity index, Maastricht ankylosing spondylitis enthesitis score, and Bath ankylosing spondylitis functional index were measured. C, A, and T alleles of CRP and A and G alleles of TLR 4 were determined using the analysis of melting curves after real-time PCR. CRP A, C, and T allele frequency in controls was 26.8, 73.2, and 36.6 %, respectively. In the PsA patient group, A, C, and T allele frequency was 9.7, 87.1, and 12.9 %, respectively. Between control and PsA groups, there was a significant difference in A, C, and T allele frequency (P = 0.008, 0.038, and 0.001, respectively). The frequency of CRP gene polymorphisms (CA, AA, CT, TA, and TT alleles) in the control group was 56.1 % and in the PsA group was 22.6 %. There was a significant difference between the two groups (P = 0.004). The absence of a CRP gene polymorphism was a risk factor for PsA (odds ratio 4.3, 95 % CI; 1.5-12.4, P = 0.005). TLR gene haploid frequency was investigated, and all control subjects had the wild-type AA allele. PsA patient GA allele frequency was 6.5 %. There was no significant difference between the two groups (P = 0.182). GA mutant allele frequency was related to PsA (odds ratio 7.03, 95 % CI; 0.32-151.9, P = 0.214). We have shown that CRP gene polymorphisms are higher in control subjects than PsA patients, and TLR 4 gene polymorphisms were found to be related to PsA.
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    Comparison of olive oil and lanolin in the prevention of sore nipples in nursing mothers
    (2013) Gungor, Ayse Nur Cakir; Oguz, Sevilay; Vurur, Gulsen; Gencer, Meryem; Uysal, Ahmet; Hacivelioglu, Servet; Uludag, Aysegul
    [No abstract available]
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    Female sexual dysfunction in androgenetic alopecia: Case-control study
    (Canadian Urological Association, 2016) Sancak, Eyup Burak; Oguz, Sevilay; Akbulut, Tugba; Uludag, Aysegul; Akbas, Alpaslan; Kurt, Omer; Akbulut, Mehmet Fatih
    Introduction: We sought to evaluate the association of female sexual dysfunction (FSD) with androgenetic alopecia (AGA) and metabolic syndrome (MetS) in premenopausal women. Methods: From December 2013 to June 2015, we performed a case-control, prospective study of 115 patients with AGA and 97 age-matched control patients without AGA from among premenopausal women who visited dermatology clinics of the two reference hospitals. Comprehensive history, anthropometric measurements, and questionnaire administration were performed for each of the total of 212 women. The Female Sexual Function Index (FSFI) was used to assess the key dimensions of female sexual function. AGA was assessed and graded by an experienced dermatologist according to Ludwig's classification. The MetS assessment was made according to the NCEP-ATP III criteria. Results: In univariate analysis, age, weight, waist circumference, hip circumference, waist-to-hip ratio, body mass index (BMI), AGA, MetS, cardiovascular event, marital status, hypertension, high fasting plasma glucose, high triglyceride, large waist, total testosterone, and free testosterone were associated with presence of FSD. In logistic regression analysis, age (odds ratio [OR] 1.21, 95% confidence interval [CI] 1.13. 1.30; p<0.001), AGA (OR 3.42, 95% CI 1.31. 8.94; p= 0.017), MetS (OR 5.39, 95% CI 1.34. 21.62; p= 0.012), and free testosterone (OR 0.18, 95% CI 0.09. 0.37; p< 0.001) were independently associated with FSD. Conclusions: Our study suggests that age, AGA, MetS, and free testosterone may have strong impact on sexual function in premenopausal women. Further studies with population-based and longitudinal design should be conducted to confirm this finding.
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    Increased Pathological Worry Levels in Patients with Alopecia Areata
    (Derman Medical Publ, 2017) Sahin, Basak; Soydas, Esra Akyol; Oguz, Sevilay; Isik, Selda; Ertekin, Hulya
    Aim: Alopecia Areata (AA) is a type of hair loss that has been considered to have associations with various psychiatric disorders. In this study, we aimed to compare pathological worry levels between patients with AA and healthy controls (HC). Material and Method: Sixty-three patients with AA and 90 HCs were included in the present study after applying inclusion and exclusion criteria. The socio-demographic characteristics, some clinical characteristics, and the scores from the Penn State Worry Questionnaire (PSWQ) were compared between groups. Results: The demographic characteristics were found to be similar between groups except for gender. The family history of AA was significantly higher in the AA group. The mean score of PSWQ in the AA group was 44.02 +/- 11.59, compared to 39.71 +/- 7.77 in the HC group. The mean score of PSWQ was significantly higher in the AA group (t=-3.27, p= 0.001). Discussion: The present study is the first to compare pathological worry between patients with AA and HCs. We suggest that pathological worry should be more thoroughly investigated in patients with AA to improve their quality of life. Also, this can be an effective approach to targeting the patients who may develop anxiety disorder.
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    Predictive value of striae gravidarum severity for intraperitoneal adhesions or uterine scar healing in patients with previous caesarean delivery
    (Taylor & Francis Ltd, 2014) Gungor, Ayse Nur Cakir; Oguz, Sevilay; Hacivelioglu, Servet; Isik, Selda; Uysal, Ahmet; Gencer, Meryem; Cosar, Emine
    Objective: Previous abdominal operations might cause severe intraperitoneal adhesions (IPA), which can complicate caesarean section (CS) procedures. When selecting the mode and timing of delivery, obstetricians are also curious about uterine scar healing if the previous operation was a CS. Uterine scar thickness is an indicator of uterine scar healing. We aimed to evaluate the possible predictive value of striae gravidarum (SG) on IPA formation and uterine scar thickness (UST). Methods: Fifty-five women with a previous CS history were evaluated for SG Davey Score. They were investigated for IPAs and lower segment uterine scar thickness during the current CS operation. Results: Out of the patients with no SG (n = 11), mild SG (n = 10) and severe SG (n = 34), 1 (9.1%), 3 (30%) and 17 (50%) had IPA, respectively (p = 0.044). The mean uterine scar thicknesses in the no SG, mild SG and severe SG groups were 3.82 +/- 4.04, 5.20 +/- 4.13 and 5.18 +/- 3.52, respectively (p = 0.561). Conclusions: To the best of our knowledge, this was the first study to investigate the relationship between SG and IPA and uterine scar thickness. The SG status of a patient with a previous delivery and abdominal operation history might help predict IPA status before planning a new operation.
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    Second to fourth digit ratio, sex differences and antropometric measuments: their relationship in children
    (Edizioni Minerva Medica, 2017) Uludag, Aysegul; Tekin, Murat; Ertekin, Yusuf H.; Sahin, Erkan M.; Cevizci, Sibel; Cibik, Birol; Oguz, Sevilay
    BACKGROUND: The aim of this study was to determine the effect of socio-demographic factors and anthropometric measurements on 2/4 digit ratio in the school aged children. METHODS: This cross-sectional study was completed in primary and secondary schools in the city center of Canakkale, Turkey. The students were seated at a table by the responsible doctor, and were asked to extend the palm of the right and left hand in the schools. Using a Vernier Caliper the 2/4 fingers were measured from the palm twice, and the results were noted together with socio-demographic information. Weight, length, waist and hip measurements were taken while students were behind a folding screen. RESULTS: A total of 1860 students from 5-14 years were included in the study. The right hand 2/4 digit ratio was 0.9765 +/- 0.035 and the left hand ratio was 0.9716 +/- 0.036 for girls. For the boys the ratios were 0.9688 +/- 0.035 for right hand and 0.9653 +/- 0.033 for left hand. The digit ratios of girls were significantly higher than boys and the right hand ratio was even greater. The 2/4 digit measurements of both hands of students were positively correlated with each other. In regression model left hand 2/4 ratio is dependent hip circumference, monthly income and gender as adjusted r(2) 0.051. The right hand 2/4 ratio was dependent gender, monthly income, hip circumference and birthweight as adjusted r(2) 0.041. CONCLUSIONS: The 2/4 digit ratio of school-aged in Turkish children differed based on gender. Digit ratios depend on the hip circumference, gender (girls have higher ratio), birthweight, gestation week and monthly income. Further research, especially the effect of monthly income, is needed.