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    Correction: Mitochondria and aging in older individuals: An analysis of DNA methylation age metrics, leukocyte telomere length, and mitochondrial DNA copy number in the VA normative aging study [Aging., 12, (2019) (2070-2083)] DOI: 10.18632/aging.102722
    (Impact Journals LLC, 2020) Dolcini, Jacopo; Wu, Haotian; Nwanaji-Enwerem, Jamaji C.; Kiomourtozlogu, Marianthi-Anna; Cayir, Akin; Sanchez-Guerra, Marco; Vokonas, Pantel
    The authors requested to correct the last name of Marianthi-Anna Kioumourtzoglou which was misspelled. This mistake does not change the content of publication. © 2020 Dolcini et al.
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    Impacts of the Mitochondrial Genome on the Relationship of Long-Term Ambient Fine Particle Exposure with Blood DNA Methylation Age
    (Amer Chemical Soc, 2017) Nwanaji-Enwerem, Jamaji C.; Colicino, Elena; Dai, Lingzhen; Cayir, Akin; Sanchez-Guerra, Marco; Laue, Hannah E.; Nguyen, Vy. T.
    The mitochondrial genome has long been implicated in age-related disease, but no studies have examined its role in the relationship of long-term fine particle (PM2.5) exposure and DNA methylation age (DNAm-age)-a novel measure of biological age. In this analysis based on 940 observations between 2000 and 2011 from 552 Normative Aging Study participants, we determined the roles of mitochondrial DNA haplogroup variation and mitochondrial genome abundance in the relationship of PM2.5 with DNAm-age. We used the GEOS-chem transport model to estimate address-specific, one-year PM2.5 levels for each participant. DNAm-age and mitochondrial DNA markers were measured from participant blood samples. Nine haplogroups (H, I, J, K, T, U, V, W, and X) were present in the population. In fully adjusted linear mixed-effects models, the association of PM2.5 with DNAm-age (in years) was significantly diminished in carriers of haplogroup V (P-interaction = 0.01; beta = 0.18, 95%CI: -0.41, 0.78) compared to noncarriers (beta = 1.25, 95%CI: 0.58, 1.93). Mediation analysis estimated that decreases in mitochondrial DNA copy number, a measure of mitochondrial genome abundance, mediated 12% of the association of PM2.5 with DNAm-age. Our data suggests that the mitochondrial genome plays a role in DNAm-age relationships particularly in the context of long-term PM2.5 exposure.
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    Mitochondria and aging in older individuals: an analysis of DNA methylation age metrics, leukocyte telomere length, and mitochondrial DNA copy number in the VA normative aging study
    (Impact Journals Llc, 2020) Dolcini, Jacopo; Wu, Haotian; Nwanaji-Enwerem, Jamaji C.; Kiomourtozlogu, Marianthi-Anna; Cayir, Akin; Sanchez-Guerra, Marco; Vokonas, Pantel
    Population aging is a looming global health challenge. New biological aging metrics based on DNA methylation levels have been developed in addition to traditional aging biomarkers. The prospective relationships of aging biomarkers with mitochondrial changes are still not well understood. Here, we examined the prospective associations of mitochondrial copy number (mtDNAcn) with several aging biomarkers - DNAm-Age, DNAm-PhenoAge, DNAm-GrimAge, and leukocyte telomere length. We analyzed 812 individuals from Veteran Affairs Normative Aging Study (NAS) with available blood samples from 1999-2013. Whole blood mtDNAcn and relative leukocyte telomere length were measured via qPCR. DNA methylation was assessed and used to calculate DNAm-Age, DNAm-GrimAge, and DNAm-PhenoAge. Linear mixed models were used to quantify the associations of mtDNAcn with DNAm-Age, DNAm-GrimAge, DNAm-PhenoAge, and leukocyte telomere length. In multivariable cross-sectional analyses, mtDNAcn is negatively associated with DNAm-Age PhenoAge and DNAm-PhenoAge. In contrast, mtDNAcn is associated with prospective measures of higher DNAm-PhenoAge and shorter leukocyte telomere length. Our study shows that higher mtDNAcn is associated with prospective measures of greater DNAm-PhenoAge and shorter leukocyte telomere length independent of chronological age. This indicates a role for mitochondrial in aging-related disease and mortality, but not the departure of biological age from chronological age.
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    Mitochondria and aging in older individuals: an analysis of DNA methylation age metrics, leukocyte telomere length, and mitochondrial DNA copy number in the VA normative aging study (vol 12, pg 2070, 2019)
    (Impact Journals Llc, 2020) Dolcini, Jacopo; Wu, Haotian; Nwanaji-Enwerem, Jamaji C.; Kioumourtzoglou, Marianthi-Anna; Cayir, Akin; Sanchez-Guerra, Marco; Vokonas, Pantel
    [Anstract Not Available]