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    Öğe
    Acil Serviste Karbonmonoksit Zehirlenmesi Tanısı Alan Hastalarda Plazma Total Tiyol Seviyelerinin Değerlendirilmesi
    (Acil Tıp Uzmanları Derneği, 2023) Delice, Orhan; Daş, Murat; Kurtoğlu Çelik, Gülhan; Kavaklı, Havva Şahin; Neşelioğlu, Salim; Hatıl, Semra Işıkoğlu
    Objective: The study aimed to measure the levels of total thiol, an antioxidant parameter, in patients who presented to the emergency department (ED) with carbon monoxide (CO) poisoning under normobaric oxygen therapy (NBOT), evaluate the time-dependent changes in total thiol levels within the first 6 hours, and examine the course of antioxidants in CO poisoning. Materials and Method: The study population consisted of 85 patients diagnosed with CO poisoning in the ED and 50 volunteers. Total thiol level was measured in the study group at the admission (T0), first (T1) and sixth hour (T6). Carboxyhemoglobin levels, cardiac markers, electrocardiography, and routinely requested tests were investigated in patients with poisoning. The total thiol level was measured in the volunteer group. Results: There was a significant decrease in total thiol mean levels between T0 and T1 (p
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    Thiol-disulphide Homeostasis in Patients with Schizophrenia: The Potential Biomarkers of Oxidative Stress in Acute Exacerbation of Schizophrenia
    (Korean College of Neuropsychopharmacology, 2024) Korkmaz, Şükrü Alperen; Ulusoy Kaymak, Semra; Neşelioğlu, Salim; Erel, Özcan
    Objective: : Recent evidence suggests that oxidative stress contributes to the pathophysiology of schizophrenia. This study aimed to compare thiol-disulphide homeostasis in acute and stable phases of schizophrenia for the first time. Methods: : Among the patients with schizophrenia, 61 in the acute-phase and 61 in the stable phase of their illness were enrolled in the study. Native thiol (NT), total thiol (TT), disulphide (SS), disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol for thiol-disulphide homeostasis were compared between the groups. The Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Positive/Negative Symptoms (SAPS/SANS), Clinical Global Impression-Severity Scale (CGI-S), Barnes Akathisia Rating Scale, and Simpson-Angus Scale were used to assess symptoms. Results: : After controlling for age, sex, body mass index, and smoking status there were significant differences in NT, TT, SS/NT, SS/TT, and NT/TT, but not SS. Thiol/disulphide homeostasis has shifted in favour of the oxidative side in patients with acute-phase compared to that in stable schizophrenia. BPRS, SAPS, and CGI-S scores were significantly correlated with all six thiol-disulphide parameters, but not SANS, when controlling for age and sex. Significant receiver operating characteristic (ROC) curves were obtained for all thiol-disulphide homeostasis parameters. Discriminant analysis was found to be statistically significant in discriminating between groups. Conclusion: : These results show that oxidative status increases thiol-disulphide homeostasis in patients with acute-phase schizophrenia compared to those with stable schizophrenia. These findings suggest that thiol-disulphide parameters can be used as biomarkers for the acute exacerbation of schizophrenia.
  • Küçük Resim
    Öğe
    Thiol-disulphide homeostasis, ischemia-modified albumin, complete blood count-derived inflammatory markers and C-reactive protein from acute mania to early remission in bipolar disorder
    (Elsevier, 2023) Korkmaz, Şükrü Alperen; Kızgın, Sadice; Fırat Oğuz, Esra; Neşelioğlu, Salim; Erel, Özcan
    Objectives There is much recent evidence that inflammation contributes to the pathophysiology of acute mania in bipolar disorder (BD). However, no study was evaluated in which the change in thiol-disulphide homeostasis, ischemia-modified albumin (IMA), complete blood count-derived inflammatory markers (CBC-IMs) and C-reactive protein (CRP) levels in bipolar patients was followed-up from acute mania to early remission. Methods Seventy-seven bipolar patients in acute mania and ninety-one HC were enrolled. We measured levels of thiol-disulphide parameters, IMA, and CBC-IMs such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), red-cell-distribution-width (RDW)-to-platelet ratio (RPR), systemic immune-inflammatory index (SII), and systemic inflammatory response index (SIRI), CRP and platelet-to-albumin ratio (PAR), after adjusting for age, gender, body-mass index (BMI) and smoking status, during acute mania to subsequent early remission. The results were compared with HC. Results The levels or ratios of all thiol-disulphide parameters except for disulphide, IMA and CRP of bipolar patients in both acute mania and early remission were significantly different from HC, after adjusting for confounders. The NLR, SII, CRP and PAR values of bipolar patients were significantly higher in only acute mania compared to HC. Significant changes in thiol-disulphide parameters and IMA levels were not found in early remission after acute mania. Limitations Short follow-up period and lack of drug-naive patients. Conclusions Our results suggest that thiol-disulphide parameters, IMA level and SIRI value might be a trait biomarkers of inflammation in BD. In addition, NLR, SII and PAR values and CRP level might be a state biomarker of inflammation in bipolar patients in a manic phase.