Yazar "Navruz, Fahriye Zemheri" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim
    Öğe
    Alterations in blood parameters, DNA damage, oxidative stress and antioxidant enzymes and immune-related genes expression in Nile tilapia (Oreochromis niloticus) exposed to glyphosate-based herbicide
    (Elsevier Inc., 2021) Acar, Ümit; İnanan, Burak Evren; Navruz, Fahriye Zemheri; Yılmaz, Sevdan
    In this study, effects of different concentrations (0, 5, 10, 20, 30, and 40 mg/L) of glyphosate-based herbicide (GBH) on Nile tilapia (Oreochromis niloticus) were investigated after a 14-day of exposure. After determination of LC50 value, effects of GBH on hematological and serum biochemical parameters in blood samples, DNA damage, lipid peroxidation and catalase activity in liver tissues, expression levels of antioxidant enzyme-related genes (SOD, CAT, GPx, and GST) and immune-related genes (TGF-β, TGF-α and IL1-β) were evaluated. The LC50 value has been found as 44.4 mg/L for GBH. GBH exposure at all concentrations caused alterations in blood parameters. GBH induced oxidative stress in liver and DNA damage in blood. Antioxidant enzyme-related genes were significantly up-regulated to suppress oxidative stress. On the other hand, the expression levels of immune-related genes decreased in fish exposure to particularly ≥20 mg/L GBH.
  • [ X ]
    Öğe
    Dose-dependent stress response of esfenvalerate insecticide on common carp (Cyprinus carpio): Evaluating blood parameters and gene expression
    (Elsevier Science Inc, 2023) Navruz, Fahriye Zemheri; Acar, Umit; Yılmaz, Sevdan; Kesbic, Osman Sabri
    Esfenvalerate is a pyrethroid insecticide used primarily in the agriculture sector for insect management. Esfenvalerate is effective against a wide range of harmful insects, including flies, cockroaches, locusts, and many other types of bugs. It is also known that esfenvalerate has toxic effects on aquatic organisms and poses significant environmental concerns. In this study, the aim is to subchronically examine the effects of sublethal concentrations of esfenvalerate insecticide on common carp (Cyprinus carpio) by assessing changes in blood parameters and resulting gene expression. For this purpose, common carp (Cyprinus carpio) were divided into 5 groups and exposed to 0.025, 0.05, 0.1, and 0.15 & mu;g/L concentrations of esfenvalerate for a period of 14 days. Blood and liver tissue samples were collected from the fish that underwent weight and length measurements. The effects on gene expression levels of immune, antioxidant, and stress-related genes in the liver tissue, including SOD, GST, Cortisol receptor, HSP70, H+-ATPase, Na+/K+-ATPase, Catalase, and GpX, were evaluated, as were the hematological and serum biochemical parameters. Significant decreases were observed in the levels of hematocrit, hemoglobin, erythrocytes, triglycerides and total protein and catalase, H+-ATPase, and GpX gene expression. Glucose, cholesterol, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase (LDH) and alkaline phosphatase (ALP), SOD, Cortisol receptor, Na+/K+-ATPase gene expression levels increased. As a result, it has been revealed that esfenvalerate insecticide causes oxidative stress in carp at all dose ranges.
  • [ X ]
    Öğe
    Effects of a Myrrh (Commiphora myrrha) Essential Oil Supplemented Diet on Haemato-Biochemical Parameters, Expression of Tissue-Specific Immune- and Stress-Related Genes, and Resistance of Cyprinus carpio to Aeromonas hydrophila Infection
    (Central Fisheries Research Inst, 2025) Acar, Umit; Yildirim, Onder; Baba, Esin; Navruz, Fahriye Zemheri; Hacisa, Mustafa; Yılmaz, Sevdan
    Plant-based additives or botanicals, have garnered considerable interest in the aquaculture industry for their multifaceted benefits in fish diets. In this study, a 30 days short term feeding experiment was designed to determine the effects of Myrrh (Commiphora myrrha) essential oil on hematological, biochemical parameters and tissue specific mRNA expression responses of common carp (Cyprinus carpio). Fish were experimentally infected with Aeromonas hydrophila and monitored for 20 days after been divided in four groups: a control group without C. myrrha and three experimental groups supplemented with 0.25%, 0.50%, and 1.0% C. myrrha essential oil (CMO 0.25, CMO 0.50, and CMO 1.0, respectively). Results revealed a significant increase in RBC count, hemoglobin, and hematocrit values compared to the control diet. Positive effects of C. myrra supplementation have been observed also in serum biochemistry parameters. mRNA transcripts of il-1 ss, tnf-alpha, il-8, sod, cat, gpx and gst genes significantly increased in spleen and liver tissue of fish fed with C. myrra supplemented diets. After the challenge with Aeromonas hydrophila, the survival rates were 60%, and 83.33%, respectively, suggesting enhanced fish resistance in the CMO 0.50 and CMO 1.0 groups compared to the control. The results suggest the immunomodulatory roles of C. myrrha essential oil.
  • [ X ]
    Öğe
    Glifosat Bazlı Herbisitin Erkek Nil Tilapiyası (Oreochromis niloticus) Üreme Dokuları ve Sperm Hücreleri Üzerine Etkileri
    (Mevlüt AKÇURA, 2022) Acar, Ümit; İnanan, Burak Evren; Navruz, Fahriye Zemheri; Yılmaz, Sevdan
    Glifosat bazlı formülasyonlar, dünyada en yaygın kullanılan herbisit tarım ilaçlarındandır. Bu çalışmada, su kaynaklı glifosatın erkek Nil Tilapyası (Oreochromis niloticus) testis, sperm kanalı, testiküler ve sağım yolu ile elde edilmiş spermatozoa örnekleri üzerine etkileri belirlenmiştir. Bu amaçla, balıklar 14 gün boyunca 0, 5, 10, 20, 30 ve 40 mg/L glifosat içeren deneme akvaryumlarında tutulmuşlardır. >10 mg/L glifosatın, sağım yoluyla ve testislerden alınmış olan spermatozoa örneklerinin motilite, canlılık süresi ve vitalite değerlerini azaltıcı etkisi gözlemlenmiştir. 40 mg/L glifosat grubunda hem testiküler hem de sağım yoluyla elde edilmiş spermatozoa örneklerinde en düşük vitalite değerleri saptanmıştır. >10 mg/L üzerindeki glifosat maruziyetinin, spermatozoa hücrelerinin oksidatif dengesinde değişimlere yol açtığı belirlenmiştir. Ayrıca, testis ve sperm kanalı dokularında glifosat etkisi ile oluşan lipid peroksidasyon seviyelerindeki azalmaların, kontrol grubuna alınan testis örneği haricinde istatistiki açıdan önemli farklar göstermediği saptanmıştır. Katalaz aktivitesi ise kontrol grubuna kıyasla >5mg/L glifosat gruplarında özellikle testis dokularında artış göstermektedir. Sperm kanalı dokusundaki oksidatif cevap, testis dokusundan farklı olduğu belirlenmiştir. Sonuç olarak, bu çalışma ile glifosat bazlı yaygın olarak kullanılan ticari bir herbisitin, erkek Nil Tilapyası balığı üreme sistemi üzerine etkileri gösterilmiştir. Ortamda bulunan özellikle 5 mg/L’den fazla olan glifosat konsantrasyonun spermatozoa parametrelerine olumsuz yansıdığı saptanmıştır. Bununla birlikte daha yüksek konsantrasyonların bu herbisitin üreme sistemi dokularındaki oksidatif stres koşullarını etkileyebildiği gösterilmiştir.