Yazar "Mutlu, Pinar" seçeneğine göre listele
Listeleniyor 1 - 14 / 14
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A Comparison of Exercise Tolerance, Measures of Cardiac Response to Exercise and Serum Markers in Chronic Obstructive Pulmonary Disease(Galenos Yayincilik, 2020) Mutlu, Pinar; Mirici, N. ArzuObjective: This study investigates the relationship between cardiac response measures and serum markers with exercise performance in patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 90 patients with stable COPD, diagnosed based on clinical findings and the GOLD spirometric criteria were included in this study. Each patient completed pulmonary function and lung diffusion tests, a six-minute walking test (6MWT), a Modified Medical Research Council Dyspnea scale, and a St. George Respiratory Questionnaire. The patient's height and body weight were obtained, and the body mass index was calculated. Serum pro-brain natriuretic peptide (pro-BNP), tumor necrosis factor-alpha, interleukin-6 (IL-6), IL-8, transferrin, and C-reactive protein levels were measured. Results: After tie evaluation of exercise tolerance with a 6MWT, exercise performance was found to be significantly associated with spirometric measurements, the level of dyspnea, quality of life, and serum pro-BNP levels. When tie measures of cardiac response to exercise were evaluated, significant relationships were noted between systolic pressure and pulse differences, and tie distance walked in a 6MWT. Conclusion: We believe that the many factors that determine exercise tolerance in COPD patients are interrelated. A clear demonstration of these relationships may, in the long-term, change the perspective of both the clinical course of the disease and its treatment strategies.Öğe Characteristics of our hypoxemic COVID-19 pneumonia patients receiving corticosteroids and mortality-associated factors(Taylor & Francis Ltd, 2022) Sengul, Aysun; Mutlu, Pinar; Ozdemir, Ozer; Satici, Celal; Turan, Muzaffer Onur; Arslan, Sertac; Ogang, NalanBackground COVID-19 is a disease associated with diffuse lung injury that has no proven effective treatment yet. It is thought that glucocorticoids may reduce inflammation-mediated lung injury, disease progression, and mortality. We aimed to evaluate our patient's characteristics and treatment outcomes who received corticosteroids for COVID-19 pneumonia. Methods We conducted a multicenter retrospective study and reviewed 517 patients admitted due to COVID-19 pneumonia who were hypoxemic and administered steroids regarding demographic, laboratory, and radiological characteristics, treatment response, and mortality-associated factors. Results Of our 517 patients with COVID-19 pneumonia who were hypoxemic and received corticosteroids, the mortality rate was 24.4% (n = 126). The evaluation of mortality-associated factors revealed that age, comorbidities, a CURB-65 score of >= 2, higher SOFA scores, presence of MAS, high doses of steroids, type of steroids, COVID-19 treatment, stay in the intensive care unit, high levels of d-dimer, CRP, ferritin, and troponin, and renal dysfunction were associated with mortality. Conclusion Due to high starting and average steroid doses are more associated with mortality, high-dose steroid administration should be avoided. We believe that knowing the factors associated with mortality in these cases is essential for close follow-up. The use of CURB-65 and SOFA scores can predict prognosis in COVID-19 pneumonia.Öğe Comparison of hyperbaric oxygen, ozone, and dexpanthenol therapies in rats with acute lung injury(Kare Publ, 2022) Yilmaz, Merve; Mutlu, Pinar; Mirici, Nihal Arzu; Kapicibasi, Hasan Oguz; Bagla, Aysel Guven; Gulen, Meltem Ickin; Korpinar, SefikaBACKGROUND AND AIM: Acute respiratory distress syndrome (ARDS) is a fatal disease pre-senting with respiratory failure. Patients with ARDS account for a considerable portion of patients staying in the intensive care unit (ICU). Therefore, advances in the treatment of these patients are of great importance. Direct or indirect injury to the lung initiates an inflammatory process. This results in impaired integrity of the alveolar-capillary membrane, pulmonary edema, and severe hy-poxia. The present study compared hyperbaric oxygen (HBO), ozone, and dexpanthenol therapies administered to rats with experimentally induced ARDS, as well as the efficacy of these therapies. METHODS: Thirty-two male Wistar Albino rats were used in the study. The rats were divided into four groups. All groups were administered antibiotherapy for 5 days after administering live Escherichia coli. Group 1 (control group) rats received intraperitoneal saline. Group 2 rats were treated with HBO. Group 3 rats received an oxygen + ozone mixture. Group 4 rats received dex-panthenol. After 5 days, anesthesia was administered to all rats, blood gases were collected from the abdominal aorta, and then the rats were sacrificed. Some of the collected blood was used for cytokine assays. The right lung tissues were used for histopathological examination. The left lung tissues were used to measure enzyme levels. RESULTS: Histopathologically, there were intra-alveolar hemorrhage, edema, intensive inflam-matory cell infiltration, fibrosis, collapse, type 2 alveolar cells, and macrophage accumulation in all groups. In terms of fibrosis/alveolar septal thickening, the dexpanthenol group had a sig-nificantly lower mean score than the control and HBO groups. In terms of alveolar collapse, the dexpanthenol group had a significantly lower mean score than all other groups. In terms of increased macrophage and type II alveolar cell counts, the ozone group had a significantly lower mean score than all other groups. There was no significant difference in immunohistochemical staining between the groups. In terms of superoxide dismutase levels, the dexpanthenol group had a significantly lower score than the control group. Regarding IL-10 levels, the ozone group had a significantly higher score than the control and HBO groups. The dexpanthenol group had a significantly higher score only than the HBO group. Regarding PaO2 levels, the ozone group had a significantly higher score than all groups. The ozone group had a significantly lower score on PaCO2 levels than all groups. CONCLUSIONS: Among the treatments, the HBO therapy increased cell injury. The ozone therapy produced anti-inflammatory effect and histopathologically positive outcomes. The ozone therapy provided significant improvement in arterial oxygenation. The dexpanthenol therapy produced antioxidant effect and histopathologically positive outcomes. The antifibrotic effect was prominent in the dexpanthenol therapy. Further studies are needed to generalize the use of these treatments in ARDS.Öğe Demographic and asthma-related characteristics of asthmatics using pressurized metered dose inhalers and dry powder inhalers(European Respiratory Soc Journals Ltd, 2024) Aksu, Kurtulus; Solak, Gurgun Tugce Vural; Mutlu, Levent Cem; Mutlu, Pinar; Sahin, Gorkem Vayisoglu; Ture, Ezgi Erdem; Yormaz, Burcu[Anstract Not Available]Öğe Demographic and Asthma-Related Characteristics of Asthmatics Using Pressurized Metered Dose Inhalers and Dry Powder Inhalers(Mary Ann Liebert, Inc, 2024) Aksu, Kurtulus; Solak, Gurgun Tugce Vural; Mutlu, Levent Cem; Mutlu, Pinar; Sahin, Gorkem Vayisoglu; Ture, Ezgi Erdem; Yormaz, BurcuBackground: Asthma controller medications can be delivered via pressurized metered dose inhaler (pMDI) or dry powder inhaler (DPI) devices.Objective: This study aimed to evaluate the frequency of exacerbations and satisfaction rate with device use in asthmatics using pMDIs or DPIs.Methods: A multicenter, cross-sectional study was conducted in adults who used pMDIs or DPIs with correct inhaler technique and good adherence for asthma treatment. Demographic and asthma-related characteristics of the subjects and data regarding device satisfaction were collected through a face-to-face interview in the outpatient clinic. Rates of pMDI and DPI users and the data were compared between the two groups.Results: The study included 338 patients (mean age: 48.6 +/- 14.5 years, 253 [74.9%] women). Among participants, 96 (28.4%) were using pMDI and 242 (71.6%) were using DPI. The age of patients using pMDI were significantly lower compared with DPI users. No significant difference was observed in terms of device satisfaction and clinical outcomes of asthma between pMDI and DPI users with good inhaler technique and good adherence.Conclusion: More asthmatics use DPIs, however, pMDIs are used in younger asthmatic patients. No significant difference in terms of device satisfaction and clinical outcomes of asthma was observed between pMDI and DPI users.Öğe Determination of anthropometric measurements in obstructive sleep apnea syndrome in Turkish population(Turkish Assoc Tuberculosis & Thorax, 2019) Ursavas, Ahmet; Ozturk, Onder; Kokturk, Oguz; Mutlu, Pinar; Kilic, Hatice; Guzel, Aygul; Aydin Guclu, OzgeIntroduction: In this study, we aimed to determine the values of anthropometric measurements and rates used in the evaluation of obstructive sleep apnea syndrome (OSAS) in our country. Materials and Methods: Twenty accredited sleep centers in thirteen provinces participated in this multicenter prospective study. OSAS symptoms and polysomnographic examination and apnea-hypopnea index (AHI) >= 5 cases OSAS study group; patients with AHI <5 and STOP-Bang <2 were included as control group. Demographic characteristics (age, sex, body mass index-BMI) and anthropometric measurements (neck, waist and hip circumference, waist/hip ratio) of the subjects were recorded. Results: The study included 2684 patients (81.3% OSAS) with a mean age of 50.50 +/- 0.21 years from 20 centers. The cases were taken from six geographical regions of the country (Mediterranean, Eastern Anatolia, Aegean, Central Anatolia, Black Sea and Marmara Region). Demographic characteristics and anthropometric measurements; age, neck, waist, hip circumference and waist/hip ratios and BMI characteristics when compared with the control group; when compared according to regions, age, neck, waist, hip circumference and waist/hip ratios were found to be statistically different (p<0.001, p<0.001, p<0.05, respectively). When compared by sex, age, neck and hip circumference, waist/hip ratio, height, weight and BMI characteristics were statistically different (p<0.001, respectively). Neck circumference and waist/hip ratio were respectively 42.58 +/- 0.10 cm, 0.99 +/- 0.002, 39.24 +/- 0.16 cm, 0.93 +/- 0.004 were found in women. Conclusion: The neck circumference was lower than the standard value in men, but higher in women. The waist/hip ratio was above the ideal measurements in both men and women. In this context, the determination of the country values will allow the identification of patients with the possibility of OSAS and referral to sleep centers for polysomnography.Öğe Evaluation of Obstructive Sleep Apnea in Menopausal Women(Aves, 2016) Mutlu, Pinar; Itil, Bahriye Oya; Celiloglu, Murat; Ikiz, Ahmet Omer; Oztura, IbrahimObjective: To demonstrate a correlation between neuroendocrine hormone changes in menopause and obstructive sleep apnea syndrome (OSAS), excluding risk factors, i.e., depression, and treatment of cases where the disease has been diagnosed. Methods: This was a case study (2009-2010) of 194 menopausal patients, excluding surgically induced cases, performed at the Obstetrics and Gynocology Clinic of Dokuz Eylul University School of Medicine Hospital. Results: Patients were queried on their demographic data, menopause and OSAS symptoms, and Epworth Sleepiness Scale (ESS) results. Fourteen patients having 10 points and above in the ESS were hospitalized for one night in Dokuz Eylul University Sleep Center and underwent polysomnography (PSG). In our study, OSAS prevalence for postmenopausal patients was found in 6.21% of the patients. Further, 28.6% of 12 patients having OSAS were found to have mild and 57.2% were found to have moderate-severe OSAS. By PSG, 14 patients were detected to have 398.5 min of average sleep time and 23.9 of Apnea-Hypopnea Index. Three patients were suggested to undergo the palliative care and 9 were suggested to undergo continuous positive airway pressure (CPAP) therapy. The average CPAP was 7.1 mmHg. A correlation was found between body mass index and LH, prolactin, E2, and free testosterone levels and OSAS. Conclusion: OSAS risk increases during menopause. Menopause is an independent risk factor for OSAS; therefore, detailed research with PSG is suggested to be performed when required.Öğe Evaluation of the clinical characteristic of psychiatric patients who are among the risk groups in the COVID-19 pandemic(Bayrakol Medical Publisher, 2022) Mutlu, Pinar; Oyekcin, Demet Gulec; Mirici, Arzu; Gonlugur, UgurAim: The pandemic caused by COVID-19 has been a major concern for public health worldwide. Traditional medical practices need to be adapted quickly to meet the needs of vulnerable patients due to the COVID-19 outbreak. One of these patient groups is the mentally ill. Although COVID-19 itself affects mental health, this study aimed to investigate the clinical characteristics of COVID-19 patients who were previously diagnosed with mental illness. Material and Methods: Patients older than 18 years of age with COVID-19 pneumonia, PCR positive or negative, thoradc CT compatible with COVID-19 pneumonia, and who also had been diagnosed with psychiatric disease between 1 April - 1 October 2020 were included in the study Psychiatric diagnoses of the patients, drugs they used, places they lived, PCR results, CT results, comorbidities, the treatment of COVID-19, and the final status of the patients were evaluated. Results: Between the specified dates, the number of patients with COVID-19 with psychiatric disease was 37 (28.24%) out of 131. The average age of patients with COVID-19 was 56.63 +/- 11.25 years, and the average length of stay in the hospital was 5.57 +/- 1.52 days. There were 35 (94.6%) patients living in a nursing home. There were 26 patients (70.3%) with a previous history of psychiatric illness, and 23 of them (62.2%) had psychotic disorders. During the treatment period, 27 (73.0%) of the patients received multiple pharmacotherapies, and atypical antipsychotic drugs (51.4%) were mostly prescribed. Discussion: As a result, in our study, we determined that living in nursing homes, having a psychiatric disorder, and taking multiple pharmacotherapies due to this psychiatric disorder increase the possibility of getting COVID-19.Öğe Expert Opinion on Practice Patterns in Mild Asthma After the GINA 2019 Updates: A Major Shift in Treatment Paradigms from a Long-Standing SABA-Only Approach to a Risk Reduction-Based Strategy with the Use of Symptom-Driven (As-Needed) Low-Dose ICS/LABA(Current Medicine Group, 2022) Ozseker, Zeynep Ferhan; Aksu, Kurtulus; Mutlu, Levent Cem; Mutlu, Pinar; Ozturk, CanPurpose of Review This expert opinion, prepared by a panel of chest disease specialists, aims to review the current knowledge on practice patterns in real-life management of mild asthma and to address the relevant updates in asthma treatment by The Global Initiative for Asthma (GINA) to guide clinicians for the best clinical practice in applying these new treatment paradigms. Recent Findings On the basis of the emerging body of evidence suggesting the non-safety of short-acting beta 2-agonists (SABA)-only therapy and comparable efficacy of the as-needed inhaled corticosteroids (ICS)-formoterol combinations with maintenance ICS regimens, GINA recently released their updated Global Strategy for Asthma Management and Prevention Guide (2019). The new GINA 2019 recommendations no longer support the SABA-only therapy in mild asthma but instead includes new off-label recommendations such as symptom-driven (as-needed) low-dose ICS-formoterol and low dose ICS taken whenever SABA is taken. The GINA 2019 asthma treatment recommendations include a major shift from long-standing approach of clinical practice regarding the use of symptom-driven SABA treatment alone in the management of mild asthma. This expert opinion supports the transition from a long-standing SABA-only approach to a risk reduction-based strategy, with the use of symptom-driven (as-needed) low-dose ICS/LABA in mild asthma patients, particularly in those with poor adherence to controller medications. The thoughtful and comprehensive approach of clinicians to these strategies is important, given that the exact far-reaching impact of this major change in management of mild asthma in the real-world settings will only be clarified over time.Öğe No increased risk of severe COVID-19 in asthma treated with biologics(Kare Publ, 2022) Beyaz, Sengul; Erecan, Emircan; Mutlu, Pinar; Ozseker, Zeynep FerhanBACKGROUND AND AIM: Biologics can be used safely for patients with severe asthma during the coronavirus pandemic, but there is still a lack of information regarding their effects during SARS-CoV-2 infection. The aim of this study was to evaluate the impact of biologic therapies on the course of SARS-CoV-2 infection and to assess the outcome of COVID-19 for severe asthmatics in pandemic conditions. METHODS: A total of 100 severe asthma patients treated with biologics (7 treated with dupilumab, 22 with mepolizumab, and 71 with omalizumab) were included. Patients' demographic, clinical, and laboratory findings as well as the course of the COVID-19 disease were evaluated. RESULTS: Of the total 100 patients, 15% of patients were diagnosed with COVID-19. There were no significant differences between SARS-CoV-2 positive and negative patient groups in terms of demographic features, atopy, comorbidity, duration of asthma, and duration of biological use. The body mass index (BMI) was higher in the SARS-CoV-2 negative group than the positive group (p=0.005). Asthma exacerbation during COVID-19 was observed in 3 patients, and only 2 were hospitalized for 5 days. SARS-CoV-2 positive group exhibited lower eosinophil and lymphocyte levels when infected with COVID-19 than before COVID-19 (p=0.01 and p=0.0009 respectively). CONCLUSIONS: The rate of COVID-19 infection was higher in patients with severe asthma receiving biologics than in the general population. However, it can be speculated that treatment with biologics may have protection against severe COVID-19 and mortality. Further studies are required to investigate the role of biologic agents, which affect the level and function of eosinophils in viral infections, especially SARS-CoV-2.Öğe Prevalence of obstructive sleep apnea in female patients with fibromyalgia(Saudi Med J, 2020) Mutlu, Pinar; Zateri, Coskun; Zohra, Ali; Ozerdogan, Ozgur; Mirici, Arzu N.Objectives: To determine the prevalence of obstructive sleep apnea in female patients with fibromyalgia (FM) presenting to physical therapy outpatient clinics. Methods: The 36-item short form health survey (SF-36) questionnaire, Berlin test, and epworth sleepiness scale were administered, along with a polysomnography to 38 female patients. This cross-sectional study comprised diagnosed with FM according to the diagnostic criteria of the American College of Rheumatology, between March 2017 and August 2019, at the Faculty of Medicine Hospital, Canakkale Onsekiz Mart University, Canakkale, Turkey. Results: Of the participants, 65.9% were found to have obstructive sleep apnea (OSA). Patients with OSA were older and had a higher disease activity score for FM. A strong positive correlation was identified between the apnea-hypopnea index (AHI) and the FA disease activity score. A negative correlation was found between AHI and the subscales of SF-36. Conclusion: A clinical assessment of female patients with FM requires a multidisciplinary approach, and patients with excessive daytime sleepiness in particular are recommended to undergo polysomnography. The authors believe that the early detection and treatment of accompanying OSA will contribute not only to the quality of life, but also to the survival of patients with FM.Öğe Primary Pulmonary Actinomycosis Mimicking Malignancy(Galenos Yayincilik, 2018) Mutlu, Pinar; Mirici, Nihal Arzu; Guven, Merve IlcinThe diagnosis of primary pulmonary actinomycosis (PPA) is still an important challenge in clinical practice due to its clinical and radiographic similarity with other infections and malignant diseases. Currently, the diagnosis can be only made histopathologically. A 67-year-old male patient was admitted to our clinic with the complaints of cough and hemoptysis for the past two months. His physical examination was non-specific. An increased non-homogeneous density was observed in the middle zone of the left hemithorax on chest X-ray. Thoracic computed tomography revealed a hypodense mass. Positron emission tomography revealed a hypermetabolic activity in the malignant mass. The patient was diagnosed with pulmonary actinomycosis through transthoracic fine needle aspiration biopsy. In conclusion, PPA should be considered in the differential diagnosis in patients with malignancy in the presence of predisposing risk factors.Öğe Retrospective analysis of false positive ratio of our patients with lung cancer at positron emission tomography-CT screen(Wolters Kluwer Medknow Publications, 2020) Kapicibasi, Hasan Oguz; Mutlu, Pinar; Alkan, Sahinur Aycan; Mirici, Nihal Arzu; Yuksel, Buse; Bakar, CoskunBACKGROUND: In lung cancer, staging is necessary to give the best treatment to the patient and to estimate the best prognosis. The aim of this study was to compare the pathology results of the lung masses and mediastinal lymph nodes and to evaluate the sensitivity and specificity values of positron emission tomography-computerized tomography (PET-CT) and to determine the maximal threshold of maximum standardized uptake volume (SUVmax). MATERIALS AND METHODS: We retrospectively evaluated the PET-CT SUVmax values and pathology results of the patients who had a mass, mediastinal lymph node, or scalene lymph node in our patients between 2016 and 2018. RESULTS: Fifty-one people and 75 pathology materials were included in our study. We used the receiver operating characteristic curve analysis to determine the cutoff value for SUVmax value and calculated the cutoff value as 6.65. In our study, the sensitivity and specificity were calculated as 63% and 71%, respectively. We calculated the positive predictive value as 73.5% and the negative predictive value as 61%. CONCLUSION: As a result, considering the common inflammatory and granulomatous diseases seen in our country, we concluded that benign diseases should be considered before malignancy in SUVmax value below 6.6. We continue to add new patients and new data to our study to find the most appropriate threshold of SUVmax value for the health values of our country.Öğe The Secret Face of Arhythmias: Obstructive Sleep Apnea Syndrome(Galenos Publ House, 2019) Mutlu, Pinar; Yilmaz, Merve; Mirici, N. ArzuObstructive Sleep Apnea syndrome (OSAS) is a clinical condition accompanied by episodes of respiratory arrest, sleep fragmentation, oxygen desaturation, and excessive daytime sleepiness due to obstructions in the upper airway during sleep. Contrary to popular belief, OSAS is much more common in society. In some patients, we can observe symptoms of OSAS easily; however, some of the patients may not indicate any symptoms. Although the interest and research on the causes of OSAS and the mortality rate associated with cardiovascular disease have increased, this relationship has still not completely understood. The results of several proven trusted clinical trials support the hypothesis that OSAS increases the risk of stroke, arrhythmias (atrial fibrillation, bradyarrhythmia, supraventricular tachycardia, ventricular arrhythmia), coronary artery disease, acute myocardial infarction, and cardiac arrest as much as essential or resistant hypertension. In this case report, we wanted to demonstrate OSAS as a cause of arrhythmia in a young obese patient without OSAS symptoms, and an arrhythmia that improved with OSAS therapy.
