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Öğe Borderline ovarian tumors: a study of 100 cases from a Tertiary Care Hospital(Termedia Publishing House Ltd, 2013) Uysal, Ahmet; Mun, Semih; Uysal, Fatma; Oztekin, Murat; Buyuktosun, Cem; Sehirali, Salim; Basogul, OmerAim of the study: The purpose of the study was to evaluate patients with borderline ovarian tumors. Material and methods: Clinical features, treatment and survival status of 100 patients with borderline ovarian tumors were retrospectively evaluated between 1998 and 2007. Results: Patients mean age was 37.75 years (range: 15-72); 22 of them were postmenopausal. Histopathological diagnoses were serous, mucinous, endometrioid and clear cell in 54%, 41%, 2% and 3% of the patients, respectively; 70 patients had stage IA disease, 8 were at stage IB, 16 at stage IC, 2 at stage IIIA, 3 at stage IIIB and 1 at stage IIIC. Restaging laparotomies were performed on 19 patients; fertility-sparing surgery was performed on 52 patients; 2 patients received chemotherapy because of advanced-stage disease. All patients are currently alive. The 5-year disease-free survival rate for 71 cases was 100%. Conclusions: Borderline ovarian tumors have excellent prognoses, and fertility-conserving surgery can be performed in young patients with early-stage disease.Öğe The Effects of Hysteroscopic Submucosal Myoma Resection on Number of Sanitary Pads(Derman Medical Publ, 2015) Mun, Semih; Uysal, Ahmet; Onoglu, Ahmet Seckin; Uysal, Fatma; Taner, Cuneyt EftalAim: To research the effect of hysteroscopic resection of submucosal myoma (HRSM) on the amount of pads used during the menstrual period in a premenopausal patient with menometrorrhagia caused by submucosal fibroids. Material and Method: A total of 27 women with submucosal fibroids were included in this prospective study using the Pictorial Blood Assessment Chart (PBAC) to evaluate quantity of menorrhagia. Bleeding evaluation and number of pads used by patients in the 6th month after HRSM were recorded. Results: The average age of patients included in the study was 41 +/- 5.1. Of 27 patients 20 (74%) had one. 4 (14%) had two and 3 (12%) had three or more submucosal myomas. The diameter of removed fibroids were 17 (63%) less than 3 cm, 6 (22%) between 3 and 5 cm and 4 (15%) were above 5 cm. In the postoperative 6th month on the day of heaviest menstrual bleeding average number of pads used dropped to 3.8 compared to 9.1 in the preoperative period (p<0.05). Discussion: HRSM performed due to menometrorrhagia in the premenopausal period significantly reduces the number of pads used and the number of days of bleeding.Öğe The impact of thrombocytosis on clinicopathological prognostic factors and survival in patients with vulvar cancer(Via Medica, 2013) Uysal, Ahmet; Gultekin, Emre; Taner, Cuneyt Eftal; Mun, Semih; Yidirim, YusufPurpose: Reactive thrombocytosis in many solid tumors has widely been studied. In the present study we aimed to investigate whether thrombocytosis is a common and prognostic factor in women with vulvar cancer. Material & Methods: The preoperative platelet counts of 41 women, treated for vulvar cancer in our onco-gynecology center between March 1994 and January 2007, were retrospectively reviewed and correlated to clinical and pathological prognostic factors and 5-year survival. The chi-square or Fisher exact tests were used to compare categorical variables. P value <0.05 was accepted for statistical significance. Results: The mean age was 65.4+/-11.3 years (range 39-83y). All patients had squamous histology. The mean platelet count was 335.42x109/L +/- 82.03 (range 142-1155x109/L). Thrombocytosis was detected in 8 (19.5%) patients. No correlation was found between thrombocytosis and grade (p=0.65), LVSI (p=0.82), tumor size (p=0.73), depth of invasion (p=0.18), lymph node metastasis (0.93), and FIGO stage (p=0.78). The mean follow up time was 118.0+/-43.1 months (range 60-213 months). At the end of the study period 14 patients (34.2%) had died, 8 (19.5%) had recurrence, 19 (46.3%) were disease-free. General 5-year survival was 68.3% (28/41). The 5-year survival rate for patients with thrombocytosis was 75.0% (6/8), which was not significantly different from the 5-year survival of patients with normal platelet counts (22/33; 66.7%) (p=0.75). Conclusion: Our study showed that, overall, thrombocytosis was found in about 20% of patients with vulvar cancer and proved to be not linked to the best known prognostic factors and survival. Thus, disease stage and inguinofemoral lymph node status continue to be the best prognostic factors for this disease.Öğe The Role of Endocrine and Endometrial Factors in Cases of Recurrent Miscarriage: A Tertiary Center Experience(Derman Medical Publ, 2015) Uysal, Ahmet; Taner, Cuneyt Eftal; Mun, Semih; Cosar, EmineAim: To investigate endocrinologic and endometrial factors in cases of recurrent abortions. Material and Method: In cases of recurrent abortions, clinical and ultrasonographic features, genetic, anatomic and immunologic factors, hormonal profiles and endometrial samplings were assessed. Chromosomal abnormalities and uterine anomalies were excluded. Results: In 8 (14%) of 57 cases with recurrent abortions, there were low progesterone levels. In 1 (1.75%) case there was a high androgen level. In 2 (3.5%) cases there was hyperprolactinemia and in another 2 (3.5%) cases there were high insulin levels. In 4 (7%) cases two scores of OGTT were high. In 51 cases where endometrial sampling was performed, only one (1.75%) case had delayed endometrial development. Discussion: We conclude that recurrent abortions have a complex etiology related to endocrinologic and endometrial factors.
