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    Circulating Salusin-beta Levels in Various Open-Angle Glaucoma Types
    (2021) Turgut, Burak; Mercan, Kadir; Ilhan, Nevin; Demır, Nesrin; Catak, Onur
    Purpose: To evaluate the levels of salusin-beta (?-Sal) in the serum in patients with open-angle glaucoma.\rMaterials and Methods: This pilot work was designed as an institutional controlled comparative clinical study. The serum ?-Sal levels of age\rand sex-matched 20 healthy volunteers as controls (Group 1), 15 patients with normal-tension glaucoma (NTG) (Group 2), 18 patients with\rpseudoexfoliative glaucoma (PXG) (Group 3) and 26 patients with primary open-angle glaucoma (POAG) (Group 4) were measured with the\renzyme-linked immunosorbent assay (ELISA) method.\rResults: There was no statistically signifi cant difference concerning age and gender among the groups (p>0. 05). The mean serum ?-Sal levels\rin Group 1, Group 2, Group 3 and Group 4 were 4977.02±3741.44 pg/mL; 1086.57±253.41 pg/mL; 1044.98±268.80 pg/mL and 868.32±181.78\rpg/mL, respectively. Although the mean ?-Sal levels in all glaucoma groups seem numerically lower than the control group, there was no\rstatistically signifi cant difference between the serum ?-Sal concentrations of the study groups (p>0.05).\rConclusion: These fi ndings suggest that serum salusin-? levels are not different among various open-angle glaucoma types. However,\rtheoretically, ?-Sal may contribute to the pathogenesis of glaucoma and may play a neuroprotective hormone in glaucoma. Further studies with\rlarge patient population are required to say whether ?-Sal plays a role in the pathogenesis of glaucomatous optic neuropathy.
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    Evaluation of Serum Concentration of the Myokine Irisin (FNDC5) in Patients with Age-Related Macular Degeneration
    (Beyoglu Eye Training and Research Hospital, 2021) Turgut, Burak; Mercan, Kadir; İlhan, Nevin; Aydoğan, Selahattin Semih
    Objectives: This study evaluated the serum irisin level of patients with age-related macular degeneration (ARMD) and compared it with that of healthy individuals. Methods: The serum irisin level of 15 healthy controls (Group 1) and 15 dry ARMD patients (Group 2) and 15 wet ARMD patients (Group 3) were measured using the enzyme-linked immunosorbent assay (ELISA) method and compared. Results: There was no statistically significant difference between the groups in terms of age or gender (p>0.05). The mean serum irisin levels of Group 1, Group 2, and Group 3 were 25.81±24.04 ng/mL, 22.93±19.05 ng/mL, and 12.38±8.16 ng/mL, respectively. Although the mean irisin level in the wet ARMD patients was lower than that of the control and dry ARMD groups, there was no statistically significant difference between the groups (p>0.05). Conclusion: The results suggest that the serum irisin level in ARMD patients is not different from that of healthy individuals. Studies of larger groups that examine the irisin level in the vitreous and neovascular membranes will further elucidate any role in the pathogenesis of ARMD.