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    Öğe
    Nutritional assessment via anthropometric and biochemical measurements with stable COPD
    (Tubitak Scientific & Technological Research Council Turkey, 2012) Meral, Mehmet; Araz, Omer; Yilmazel Ucar, Elif; Yilmaz, Nusret; Mirici, Nihal Arzu
    Aim: Nutritional assessment is important for the management of chronic obstructive pulmonary disease (COPD). This study aims at investigating the relation between the anthropometric and biochemical parameters for nutritional assessment with pulmonary function tests in COPD. Materials and methods: This is a prospective, cross-sectional study. Thirty-nine patients with stable COPD were enrolled the study. We evaluated the anthropometric [body mass index (BMI), skinfold thickness (SFT), and arm muscle circumference (AMC)), biochemical [serum total protein, albumin, transferrin, and blood urea nitrogen (BUN)], and spirometric [forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), and FEV1/FVC] measurements, as well as the correlations among them. Results: There was a significant positive correlation between BMI and the other anthropometric parameters. There was no statistically significant correlation between the spirometric measurements and the biochemical parameters. We detected a positive correlation between SFT and serum albumin and total protein, and a negative correlation between BUN and AMC. Conclusion: Anthropometric and biochemical parameters may be used for nutritional assessment and nutritional support as criteria in stable COPD patients.
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    Öğe
    Steroids in acute exacerbations of chronic obstructive pulmonary disease: are nebulized and systemic forms comparable?
    (Lippincott Williams & Wilkins, 2009) Gunen, Hakan; Mirici, Arzu; Meral, Mehmet; Akgun, Metin
    Purpose of review Systemic corticosteroids are strongly recommended in the treatment of exacerbations of chronic obstructive pulmonary disease (COPD). As COPD patients are usually elderly and are relatively immobile, side effects of systemic corticosteroids frequently outweigh their beneficial effects. On the contrary, nebulized corticosteroid solutions have a negligible systemic side-effect profile. In this review, as an alternative to systemic corticosteroids, the place of nebulized corticosteroids in exacerbation periods of COPD was summarized. Recent findings The number of trials in the literature is increasing. Regarding the available data, high dose nebulized budesonide was found as effective as systemic corticosteroids in exacerbations of COPD. The side-effect profile, blood glucose level in particular, is better for nebulized budesonide. Summary Findings from recent studies are giving a positive impression on the role of high dose nebulized budesonide in exacerbations of COPD. However, larger and statistically high powered trials testing different types of nebulized corticosteroid solutions with varying dosages are still lacking. Before recommending the routine use of nebulized corticosteroids in exacerbations, present findings need to be confirmed with further studies of high quality.