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    Alterations in Iris Structure and Pupil Size Related to Alpha-1 Adrenergic Receptor Antagonists Use: Implications for Floppy Iris Syndrome
    (Mary Ann Liebert, Inc, 2013) Tufan, Hasan Ali; Gencer, Baran; Kara, Selcuk; Comez, Arzu Taskiran; Kurt, Hasan Anil; Alan, Cabir
    Purpose: To evaluate structural alterations of iris and pupil diameters (PDs) in patients using systemic alpha-1-adrenergic receptor antagonists (alpha-1ARAs), which are associated with intraoperative floppy iris syndrome (IFIS). Methods: Eighty-eight eyes of 49 male were evaluated prospectively. Patients were assigned to 2 different groups. Study group included 23 patients taking any systemic alpha-1ARAs treatment, and control group included 26 patients not taking any systemic alpha-1ARAs treatment. All patients underwent anterior segment optical coherence tomography to evaluate iris thickness at the dilator muscle region (DMR) and at the sphincter muscle region (SMR). The PD was measured using a computerized infrared pupillometer under scotopic and photopic illumination. Results: The study group included 46 eyes of 23 patients and the control group included 42 eyes of 26 patients. Most treated patients were on tamsulosin (16/23). Mean age was similar in the study and control groups (61.9 +/- 7.1 vs. 60.3 +/- 8, 2 years, nonsignificant). DMR (506.5 +/- 89.4 vs. 503.6 +/- 83.5 mu m), SMR (507.8 +/- 78.1 vs. 522.1 +/- 96.4 mu m) and the DMR/SMR ratio (1.0 +/- 0.15 vs. 0.99 +/- 0.23 mm) was similar in the study and control groups and these differences were nonsignificant. Scotopic PDs were also similar in both groups (3.99 +/- 1.11 vs. 3.74 +/- 1.35, nonsignificant). A significantly reduced photopic PD (2.89 +/- 0.55 vs. 3.62 +/- 0.64, P < 0.001) and an increased scotopic/photopic PD (1.42 +/- 0.44 vs. 1.02 +/- 0.30, P < 0.001) were found in the study group. Conclusions: Evaluating PD alterations might be more useful than evaluating iris structural alterations in predicting IFIS. There is still a need for a reliable method that will determine the possibility of IFIS.
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    Endothelial Dysfunction and Ischemia-Modified Albumin Levels in Males with Diabetic and Nondiabetic Erectile Dysfunction
    (Hindawi Ltd, 2022) Kurt, Hasan Anil; Demirci, Emrah; Alan, Cabir
    In this study, we aimed to determine endothelial dysfunction and ischemia-modified albumin (IMA) levels in patients diagnosed with erectile dysfunction (ED) and to examine the relationship between these and diabetes disease. 86 male patients (46 patients with diabetes, age: 51.5 +/- 9.2 and 40 patients with nondiabetes (control group), age: 54.78 +/- 12.2) were included in the study. IMA, a new indicator of tissue ischemia and oxidative stress, was checked. Superoxide dismutase (SOD) activity, another oxidative stress indicator, was examined. Endothelin-1 (ET-1), one of the parameters of endothelial dysfunction, was measured. Additionally, endothelial function was evaluated with flow-mediated vasodilatation (FMD). Student's t-test was used for statistical evaluation. p values less than 0.05 were considered statistically significant. SOD activity was significantly lower in the diabetic group than in the control group, and ET-1 was significantly higher (p < 0.001). IMA was found to be significantly higher in the diabetic group than the control group (p < 0.001). FMD was significantly lower in diabetic group compared to the control group (p < 0.002). According to our findings, the co-occurrence of erectile dysfunction and diabetes demonstrates a complex condition that includes endothelial dysfunction, oxidative stress, and tissue ischemia. When the correlation of indicators, which are markers, was examined, the severity of the co-occurrence of diabetes and erectile dysfunction was again demonstrated.
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    Nitric oxide and asymmetric dimethyl arginine (ADMA) levels in an experimental hydronephrotic kidney caused by unilateral partial ureteral obstruction
    (Brazilian Soc Urol, 2016) Alan, Cabir; Kurt, Hasan Anil; Topaloglu, Naci; Ersay, Ahmet Resit; Cakir, Dilek Ulker; Basturk, Gokhan
    Aim: Our aim is to measure asymmetric dimethyl arginine and nitric oxide levels in rats with induced unilateral acute ureteral obstruction to research the effects on the kidney. Material and Methods: The study included 21 adolescent (average age 6 weeks) Sprague-Dawley male rats weighing between 240-290g divided at random into 3 groups. Group-1: Control group (n= 6): underwent no procedures. Group-2: Sham group ( n= 6): underwent the same procedures as the experimental group without ureter and psoas muscle dissection. Group-3: Group with induced partial unilateral ureteral obstruction (n= 9). All rats were sacrificed after 12 weeks. Superoxide dismutase enzyme activity and nitrite and nitrate salt levels were measured in renal tissue. Plasma nitrite-nitrate and ADMA levels were examined. Results: In the experimental group histopathological changes observed included renal pelvis dilatation, flattened papillae, sclerotic glomerulus and fibrosis. In the experimental group tissue SOD and blood ADMA levels were higher than the control and sham groups (p< 0.05) while tissue NO and plasma NO values were lower than in the sham and control groups (p< 0.05). Conclusion: Oxidative stress and disruption of NO synthesis play an important role in renal function and histopathological changes after obstructive renal disease. To prevent renal complications developing after obstructive nephropathy we believe that a new strategy may be research on reducing ADMA.
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    The relationship between pain beliefs and anxiety levels in patients undergoing urologic surgery
    (Ibn Sina Trust, 2022) Alan, Handan; Kurt, Hasan Anil
    Aim: The study was completed with a descriptive design with the aim of determining the effect of preoperative stress on pain beliefs and used a relationship seeking design with the aim of revealing whether there is a significant correlation between pain beliefs and surgery anxiety levels among patients about to undergo surgical procedures in the urology clinic. Material and method: With descriptive and relationship seeking type, the study was completed with 112 patients admitted to the urology clinic for surgical procedures. For collection of data, a personal information form, pain beliefs scale and preoperative anxiety scale were used. Results: The majority of volunteers participating in the research were male (62.5), married (74.1%), aged 51 years or older (56.3%), primary school graduates (28.6%) and retired (38.4%) with moderate income levels (48.2%). Most patients had spinal anesthesia (48.1%) administered. There was a significant difference found between the surgery anxiety levels and pain beliefs with the anesthesia type administered. There was a negative, low power and statistically very advanced correlation between surgery anxiety and pain beliefs (r: -0.445; p<0.05). Additionally, among the pain belief subdimensions psychological beliefs were mostly correlated with surgery anxiety (r: -0.546; p<0.05). Conclusion: The research found a correlation between anxiety levels and pain beliefs of patients and concluded that researching this in different samples and nurses assessing the pain beliefs of patients will reduce anxiety.
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    Unexpected severe hepatotoxicity of ciprofloxacine: two case reports
    (Taylor & Francis Ltd, 2011) Alan, Cabir; Kocoglu, Hasan; Ersay, Ahmet Resit; Ertung, Yunus; Kurt, Hasan Anil
    Ciprofloxacin is a fluoroquinolone antibiotic that has a relatively low rate of occurence of adverse side effects. However, increasing evidences suggest that ciprofloxacin may cause unexpected severe liver damage. Especially, the risk of hepatotoxicity is significantly higher in elderly men receiving drug for a long time. In this article, 2 cases of unexpected severe hepatoxicity of ciprofloxacin are presented.