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    Association of SARS-CoV-2 IgG Antibody Levels with Clinical/Laboratory Characteristics in COVID-19 Patients: Data from a Turkish Study
    (Clin Lab Publ, 2022) Karaali, Ridvan; Dinc, Harika O.; Ozdemir, Yusuf E.; Dalar, Zeynep G.; Kurt, Ahmet F.; Aktas, Ayse N.; Sirekbasan, Serhat
    Background: COVID-19 causes clinical manifestations ranging from asymptomatic infection to multi-organ failure. It is reported that those with severe disease have higher anti-SARS-CoV-2 antibody titers compared to asymptomatic or mild cases. We evaluated the correlation of antibody responses with laboratory and clinical indicators in COVID-19 patients. Methods: Seventy-nine male and 66 female patients (mean age: 39) with at least one positive SARS-CoV-2 RTPCR test and SARS-CoV-2 IgG antibody result after acute infection were included. Results: Seventy-six (52%), 45 (31%), and 24 (17%) patients had mild, moderate, and severe clinical findings, respectively. Patients with high body mass index and advanced age had significantly more severe disease (p < 0.001). A significant correlation was found between the increase in lymphopenia, C-reactive protein, ferritin, D-dimer, and lactate dehydrogenase and the severity of clinical findings (p = 0.0001). SARS-CoV-2 IgG antibody test was positive in 128 (88.3%) patients. A significant correlation was found between disease severity and antibody levels in the comparison of all groups (p < 0.001). Conclusions: Long-term monitoring of immune responses will be required to determine the appropriate time for the administration of new vaccines.