Yazar "Krokosz, Anita" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    A multifaceted assessment of strigolactone GR24 and its derivatives: from anticancer and antidiabetic activities to antioxidant capacity and beyond
    (Frontiers Media Sa, 2023) Pyrzanowska-Banasiak, Agata; Tumer, Tugba Boyunegmez; Bukowska, Bozena; Krokosz, Anita
    Background: Strigolactones are signaling molecules produced by plants, the main functions are the intracorporeal control of plant development and plant growth. GR24 strigolactone is one of the synthetic strigolactones and due to its universality and easy availability, it is a standard and model compound for research on the properties and role of strigolactones in human health.Purpose: In this research work, the impact of mainly GR24 strigolactone on the human body and the role of this strigol-type lactone in many processes that take place within the human body are reviewed.Study design: The article is a review of publications on the use of GR24 strigolactone in studies from 2010-2023. Publications were searched using PubMed, Elsevier, Frontiers, and Springer databases. The Google Scholar search engine was also used. For the review original research papers and reviews related to the presented topic were selected.Results: The promising properties of GR24 and other strigolactone analogs in anti-cancer therapy are presented. Tumor development is associated with increased angiogenesis. Strigolactones have been shown to inhibit angiogenesis, which may enhance the anticancer effect of these gamma-lactones. Furthermore, it has been shown that strigolactones have anti-inflammatory and antioxidant properties. There are also a few reports which show that the strigolactone analog may have antimicrobial and antiviral activity against human pathogens.Conclusion: When all of this is considered, strigolactones are molecules whose versatile action is their undeniable advantage. The development of research on these phytohormones makes it possible to discover their new, unique properties and surprising biological activities in relation to many mammalian cells.
  • Küçük Resim
    Öğe
    Precarcinogens in food – Mechanism of action, formation of DNA adducts and preventive measures
    (Elsevier Ltd, 2023) Bukowska, Bożena; Duchnowicz, Piotr; Boyuneğmez Tümer, Tuğba; Michałowicz, Jaromir; Krokosz, Anita
    Food quality and food composition play key roles in human health. Food may contain harmful ingredients apart from the basic ingredients beneficial to our body. A harmful group of substances entering food from the environment are heavy metals and pesticides. Other toxicants, such as mycotoxins are produced during action of microorganisms contaminating food. The second group of compounds, including heterocyclic aromatic amines, nitrosamines, and acrylamide are formed in food during its processing or improper storage. Due to metabolic activation, these substances are transformed into precancerogens, i.e. electrophilic derivatives that finally form DNA adducts. DNA sites susceptible to the action of electrophilic compounds are atoms with a slight negative charge, especially the N7 position of guanine and N3 of adenine. These modifications may result in various mutations, and consequently, may lead to cancer development. This paper presents the general characteristics of main precancerogens, such as mycotoxins, polyaromatic hydrocarbons, heterocyclic aromatic amines, nitrosamines, and acrylamide present in various food products, formation of specific adducts of these substances with DNA, as well as describes biological consequences of adducts formation. Moreover, different strategies for reducing the levels of these contaminants in food material are discussed.