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    Central pontine myelinolysis due to chronic alcohol use: Case report
    (Neurological Society R.O.C (Taiwan), 2020) Ocak, Özgül; Çelik, Hamit; Korkmazer, Bora; Ocak, Barış; Karaman, Handan Işın Özışık
    Central pontine myelinolysis (CPM) is a neurological disorder characterized by demyelination on the bottom of pons. CPM is known to be the most common clinical presentation of osmotic demyelination syndrome. Osmotic stress formed by rapid correction of hyponatremia in glia cells is thought to be important in pathogenesis. Oligodendroglias are more sensitive to dehydration and volume changes as they are tightly aligned in the pontine. Chronic alcohol use is a rare cause of osmotic demyelination. In chronic alcoholics, central pontine myelinolysis may be asymptomatic or mild symptoms may develop. We presented the case to emphasize that chronic alcoholism is a rare cause of central pontine myelinosis. © 2020, Neurological Society R.O.C (Taiwan). All rights reserved.
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    Osmotic Demyelination Syndrome in A Normonatremic Patient with Chronic Kidney Disease
    (Galenos Yayincilik, 2020) Ocak, Ozgul; Urfali, Furkan Erturk; Korkmazer, Bora; Karaman, Handan Isin Ozisik
    Osmotic demyelination syndrome (ODS), also known as central pontine myelinolysis, is a neurological disorder characterised by myelin loss in the central pons and other parts of the brain, such as the basal ganglia, lateral geniculate bodies, external and internal capsules and cerebellum. ODS is a demyelinating disorder associated with rapid correction of hyponatraemia. Classically, this is associated with hyponatraemia, but it can also occur in the presence of normonatremia. Changes in osmolality are found to be responsible in the pathogenesis of the lesions. Rarely, pontine myelinosis with delirium was also described in normonatremic patients. We report the clinical and radiological findings of a normonatremic 45-year-old female patient with chronic kidney disease, who experienced central pontine myelinolysis. This report aims to show that pontine myelinolysis may also occur in normonatremic circumstances, and early, rapid management of the disorder is important to prevent permanent damage.