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    A STUDY ON THE EFFECTS OF WOOD VINEGAR ON WEEDS AND CULTIVATED PLANTS IN THE WHEAT AGRO-ECOSYSTEMS
    (Parlar Scientific Publications (P S P), 2019) Koc, Ibrahim; Namli, Ayten; Mendes, Mehmet; Pinar, Suleyman Mesut; Cig, Fatih; Yardim, Erdal Necip
    This study was conducted to determine the effects on the weeds and cultivated plants in the wheat agro-ecosystems of the wood vinegar in the biopesticide potential obtained from hazelnut shells on certain growth and yield parameters. The study was conducted based on the Randomized Blocks Testing Design with repeated four times. In the experiment, treatments of 0.5%, 1.0%, 2.0%, 3.0%, 4.0%, and 5.0% mL doses of wood vinegar were administered, and only tap water was given to the control group. It was found that the 4% mL dose had positive effects on cultivated plant height and that the 1% mL dose had positive effects on thousand kernel weight and seed per spike compared with the control. It was seen that its effect on weeds dry weight is changed according to the years (P=0.011). In 2015-2016, it was found that 3% mL increased and 0.5%, 1% and %5 mL decreased the weight of dry grass. In the test field; weeds determination is made from 12 families. In 2014-2015, Polygonum bellardii, Eremopoa altaica and Microthlaspi perfoliatum; and in 2015-2016, Eremopoa altaica, Erodium absinthoides, Lactuca serriola and Polygonum bellardii was seen most.
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    In Vitro Cytotoxicity and Antioxidant Evaluation of Oak (Quercus sp.) and Hazelnut Shell (Corylus avellana L.) Pyrolized Wood Vinegar: MTT Assay and CUPRAC Results
    (Springer, 2026) Koc, Ibrahim; Sabancilar, Ilhan; Kaya, Seckin; Mendes, Mehmet; Keskin, Cumali; Eftekhari, Aziz
    Wood vinegar, also known as pyroligneous acid, is an organic liquid byproduct of wood pyrolysis, rich in compounds such as acetic acid, phenols, and ketones. This study aimed to evaluate the antioxidant and anticancer properties of wood vinegar derived from oak (Quercus sp.) residues (WVO) and hazelnut shells (Corylus avellana L.) (WVH) under in vitro conditions. Method: Wood vinegars obtained from oak trash and hazelnut shell waste were tested for biological activity. The antioxidant capacity was assessed using the copper(II) reducing antioxidant capacity (CUPRAC) method. Cytotoxic effects were evaluated using the MTT assay on healthy human endothelial cells (HUVEC) and two cancer cell lines (HT29-colon adenocarcinoma and U2OS-osteosarcoma) at concentrations ranging from 1.25% to 20% (v/v) over 24, 48, and 72-hour exposure periods. The results revealed significant interactions between vinegar type, concentration, and exposure duration. Notably, the 10% and 20% (v/v) concentrations produced significantly different absorbance values compared to lower concentrations across all time points. A dose-dependent decrease in cell viability was observed, particularly in the cancer cell lines, while healthy cells exhibited relatively higher resistance. The study demonstrates that wood vinegar exhibits promising antioxidant and selective anticancer properties, with cytotoxic effects being more pronounced at higher concentrations. These findings suggest that wood vinegar may offer potential as a natural anticancer agent. Further research is warranted to elucidate the underlying mechanisms and to explore their possible therapeutic applications.