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Öğe Association between serum inhibin-B levels and coronary artery disease in aging males(Termedia Publishing House Ltd, 2013) Kocoglu, Hasan; Alan, Cabir; Cakir, Dilek Ulker; Malkoc, Ercan; Cosansu, Kahraman; Kinlmaz, Bahadir; Ertung, YunusIntroduction: Atherosclerosis is a systemic disorder. It is a frequent leading cause of coronary artery disease (CAD). Similarly, atherosclerotic vascular alterations could lead to testicular arterial blood flow reduction and impairment of testicular function with age. Inhibin-B has been validated as a valuable serum marker of testicular functions and its correlation with testicular volume was shown in some studies done before. The purpose of this study is to investigate the association between serum inhibin-B levels and CAD in elderly men. Material and methods: Between March 2009 and March 2010, fifty-two 50-80-year-old consecutive patients with Gensini score over 20 and ejection fraction (EF) > 50% were included in the study as the CAD group. Fifty healthy men without any cardiac disease history were recruited as the control group. All patients in the CAD group who had indications for coronary artery angiography underwent selective coronary artery angiography. Results: Inhibin-B, total testosterone and testicular volume levels were found to be significantly lower in the CAD group in comparison with the control group (p = 0.004, p < 0.0001, and p = 0.001 respectively). Conclusions: In this study, although no correlation was found in CAD patients between Gensini score and inhibin-B or testicular volume, inhibin-B levels and testicular volume were significantly lower in patients with CAD than in healthy men. In order to fully assess the relationship between serum inhibin-B levels and CAD, multi-centered prospective and longitudinal studies must be done in elderly male patients.Öğe Prognostic Value of TIMI Frame Count in Patients with Metabolic Syndrome(Galenos Yayincilik, 2011) Mammadov, Vusal; Kinlmaz, Bahadir; Yildiz, Hicran; Dashdemirov, Rafael; Mahmudov, Rashad; Bakhshaliyev, AdilBackground: The aim of our study was to determine the coronary angiographic distribution and frequency of atherosclerotic lesions in the coronary arteries in patients with stable angina and metabolic syndrome (MS) as well as to assess the association of these lesions with TIMI frame count and combinations of MS criteria. Methods: Two hundred sixty-one patients aged 61.8 +/- 1.4 years were included in the study. All subjects were divided into three large groups: group 1 - patients with significant coronary artery stenosis and with MS (n= 148), group 2 -patients with significant coronary artery stenosis and without MS (n= 75), and group 3 -patients without significant coronary artery stenosis and without MS (n= 38). At the same time, the patients in group 1 were again divided into 3 subgroups based on the number of MS criteria. Arterial blood pressure (BP), waist circumference (WC), and levels of fasting glucose (FG), triglycerides (TG) and high-density lipoproteins (HDL) were measured in all patients. All subjects underwent coronary angiography and TIMI frame count was calculated. Results: According to the results in patients with stable angina with 5 criteria of MS, the TIMI frame count was significantly greater than in patients with stable angina with 3 and 4 criteria of MS. While in the group of patients with stable angina with 3 criteria of MS, the most frequent combination found was BP + WC + FG (28.3 +/- 6.2%), in patients with stable angina with 4 MS criteria, it was BP + WC + FG + HDL combination (48.0 +/- 7.1%). Conclusions: The TIMI frame count method is simple, inexpensive and broadly applicable and plays role in the understanding of the physiology and pathophysiology of coronary artery blood flow in patients with stable angina and MS. For this reason, the calculation of TIMI frame count in patients with stable angina and MS has an important place in selecting the treatment options and determining the prognosis of the disease.Öğe The Crucial Importance of Optimal Primary and Secondary Prevention of Cardiovascular Disease during COVID-19 Pandemic(Taiwan Soc Cardiology, 2020) Aksit, Ercan; Gazi, Emine; Kinlmaz, Bahadir; Yildirim, Ozge Turgay; Aydin, Fatih[Anstract Not Available]
