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    Half-Sandwich Ru(II) Complexes Bearing 2-(2¢-quinoly)benzimidazoles with Anticancer Activity
    (AMG Transcend Association, 2024) Erdem, Ahmet; Mutlu, Dogukan; Kilincarslan, Rafet; Dayan, Osman; Arslan, Sevki
    In this article, cytotoxic and apoptotic properties of previously synthesized and characterized four different half?sandwich ruthenium (II) complexes (C1-C4) with 2-(2¢-quinoly) benzimidazole frameworks (L1-L5) were described. These Ru (II) complexes (C1-C4) had strong cytotoxic activity towards the human glioblastoma (U373) cancer cell line with low toxicity to the non-cancerous human embryonic kidney (HEK293) cell line. Mechanistic studies revealed that all complexes caused apoptosis induction by activating caspases with upregulation of Bax and downregulation of Bcl-2. Our results indicate that ruthenium (II) complexes with 2-(2¢-quinoly) benzimidazole frameworks, especially C1 and C4, had a higher cytotoxic and apoptotic activity in human glioblastoma cells, and they should be further evaluated in detail for its anticancer properties as a new therapeutical strategy for glioblastoma. © 2024 by the authors.
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    Synthesis, thermal, electrochemical and catalytic behavior toward transfer hydrogenation investigations of the half-sandwich RuII complexes with 2-(2?-quinolyl)benzimidazoles
    (Elsevier, 2020) Erdem, Ahmet; Kilincarslan, Rafet; Sahin, Cigdem; Dayan, Osman; Ozdemir, Namik
    A series ligands (L3-14) of derived from 2-(2'-quinolyl)benzimidazole (QuBim, L-1) and 2-(2'-quinolyl)-5,6-dimethylbenzimidazole (QuDmBim, L-2) which are an NN-type ligands have been synthesized and characterized with various techniques such as NMR, UV-vis, FT-IR spectroscopy, elemental analysis and X-ray diffraction. The substituted ligands derived from QuBim and QuDmBim have been used as sustaining ligands in the Ru-II-catalyzed transfer hydrogenation (TH) of acetophenone to secondary alcohols in the presence i-PrOH/KOH. The half-sandwich complexes (C1-14) of Ru-II with NN-type ligands have been synthesized by cleavage of [(eta(6)-p-cymene)Ru(mu-Cl)](2) dimer. The resulting complexes have been characterized by NMR, UV-vis, FT-IR spectroscopy and elemental analysis. The thermal and electrochemical properties of selected complexes and ligands were investigated. (C) 2020 Elsevier B.V. All rights reserved.