Yazar "Kilinc, Nihal" seçeneğine göre listele
Listeleniyor 1 - 13 / 13
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A Rare Form of Mesothelioma: Malignant Pleural Deciduoid Mesothelioma(Aves, 2014) Alar, Timucin; Ozcelik, Cemal; Kilinc, Nihal; Yilmaz, UfukMesothelioma usually develops in elder male patients that are exposed to asbestos. Deciduoid mesothelioma is a rare variant of epithelioid mesothelioma and has a poorer prognosis than epithelioid mesothelioma. As this subtype was seen in the peritoneum of young females and its relation with asbestos was not definite, these lesions were formerly thought to be stimulated by endogenous hormones. In the subsequent years, a relation was established between this tumor and asbestos since it was seen in the pericardium and pleura of males. In this paper, we present a 64-year-old male patient with asbestos exposure, diagnosed as having malignant pleural deciduoid mesothelioma, in which a long survival was provided with chemotherapy after surgery.Öğe Atypical Localization of Enchondroma in the Calcaneus(Amer Podiatric Med Assoc, 2015) Komurcu, Erkam; Kaymaz, Burak; Golge, Umut Hatay; Goksel, Ferdi; Resorlu, Mustafa; Kilinc, NihalA 53-year-old man presented to the orthopedic outpatient clinic with pain and swelling in the right heel without any trauma. On physical examination and radiologic assessment, a lesion with calcification and peripheral sclerosis was detected in the medullary cavity of the calcaneus, and computed tomographic images revealed cortical thinning adjacent to the lesion. Magnetic resonance images showed a 23 x 19-mm lesion. Tru-Cut biopsy, performed to clarify the diagnosis, revealed an enchondroma. As a definitive treatment, curettage of the lesion and grafting of the cavity was performed. Although enchondromas are common pathologic abnormalities of the skeleton and are usually asymptomatic, atypical localization, such as the calcaneus, and atypical clinical manifestations, such as heel pain, should also be kept in mind.Öğe Effects of ELF-MF and Strontium Ranilate on Periodontium in Rats (Duble Blind)(Medwell Online, 2011) Kaya, Filiz Acun; Akdag, Mehmet Zulkuf; Kaya, Can Ayhan; Celik, Mustafa Salih; Kilinc, Nihal; Ozekinci, Selver; Saribas, EbruIn the present experimental study, it was investigated the periodontium of rats that exposed to Extremely Low Frequency-Magnetic Field (ELF-MY), overectomized bilaterally and treated with Strontium Ranelate (SR). The experiments were performed on 75 female Sprague-Dawley (4 months) rats. The rats were divided into five groups (n = 15). All rats were subjected to bilateral ovariectomy except those in I and III groups. Bilateral ovariectomy was performed before 4 days at the beginning of the experiments under ketamine anesthesia (100 mg kg(-1), intramuscularly) and II, IV and V groups animals were subjected to 1.5 mT ELF-MT exposure during 6 months, 4 h a day starting 5th day after the surgery. There were statistically significant differences among the all groups in the case of periodontal ligament, alveolar bone and gingiva (p<0.05). As a result of the study there were different levels of histopathologic changes occured between control and experimental changes in the case of all periodontal tissue examination. These results may hypothese that both ELF-MF and Strontium renalate have effects on periodontal tissues.Öğe Effects of Extremely Low Frequency Magnetic Fields on Periodontal Tissues and Teeth in Rats(Medwell Online, 2011) Kaya, Filiz Acun; Akdag, Mehmet Zulkuf; Kaya, Can Ayhan; Dasdag, Suleyman; Yavuz, Izzet; Kilinc, Nihal; Dogru, Arzum GulerThe aim of this study is to research the effects of ELF magnetic fields on periodontal tissues and teeth in rats histopathologically. The experiments were performed on 27 male Sprague-Dawley rats, aged 4 months at the beginning of the study, weighing (342.4 +/- 38.89) g and fed with standard pelleted food. The rats were divided into three groups; two experimental and one control (sham). Experimental groups were exposed to 100 and 500 mu T ELF magnetic fields during 10 months, 2 h a day, respectively. Third group was sham that were treated like experimental group except ELF magnetic fields exposure in methacrylate boxes. There was no statistical difference between the experimental groups among all tissues (p>0.05). Alveolar bone, pulp and gingiva there were statistically significant differences among the groups of sham and 1st experimental, sham and 2nd experimental (p<0.05). The statistical difference between the experimental and sham groups in the study makes us to think that ELF magnetic fields may have effects on periodontal tissues and teeth.Öğe Effects of Radiofrequency Radiation by 900 MHz Mobile Phone on Periodontal Tissues and Teeth in Rats(Medwell Online, 2008) Kaya, Filiz Acun; Dasdag, Suleyman; Kaya, Can Ayhan; Akdag, Mehmet Zulkuf; Yavuz, Izzet; Kilinc, Nihal; Kaya, SadullahThe aim of this study, is to research an answer to the question of have mobile phones effects on periodontal tissues and teeth. Twenty eight Wistar Albino adult male rats (4 months) with initial average weight of 267 +/- 15 g were obtained from the Medical Science Application and Research Center, caged individually and fed with standard pelletted food (TAVAS Inc. Adana, TR). They were separated into three groups such as cage control (n = 7), sham exposed (n = 7) and experimental (n = 14) and kept on a 14/10 h light/dark schedule. The rats were confined in a Plexiglas carousel and rat heads in the carousel exposed to 900 MHz microwave exposure emitted from generator. For the study group, rats exposed to the radiation 2 h per day (7 days in a week) for 10 months. Although, there was no statistical difference determined among the groups of experimental and sham groups (p>0.05), there were numerically more individuals effected of RF radiation in the experimental group. In our study is the statistically significant difference among the groups of experimental, sham and control groups in the case of vasodilatation in periodontal ligament and alveolar bone (p<0.05). By the histopathologic evaluation abnormal changes like vasodilatation and focal bleeding areas were determined in periodontal ligament, alveolar bone, gingiva and pulpa among some individuals. These degenerations were in different levels. These findings of our study indicates that there is need to more animal, human being and epidemiologic studies including much more individuals.Öğe Evaluation of circulating cell-free nucleic acids in health workers occupationally exposed to ionizing radiation(Springer Heidelberg, 2022) Kilinc, Nihal; Onbasilar, Mehmet; Cayir, AkinRadiology workers might constantly be exposed to low-dose ionizing radiation due to their profession. Low doses of radiation in a short exposure time have the potential to alter the genome, which might potentially lead to diseases. The main objective of this study was to determine whether the amount of cell-free nucleic acids in plasma samples of radiation-exposed workers was different from the general public, in other words, non-exposed individuals. In this context, we investigated the association between radiation exposure and cell-free nucleic acids concentration by using radiation exposure parameters. The study consisted of 40 radiology workers and 40 individuals who were not exposed to ionizing radiation. The plasma concentrations of cell-free DNA, RNA, and miRNA were measured fluorometrically. We found that the ccfRNA concentration of the radiation-exposed group was significantly different from that of the non-exposed group (p = 0.0001). However, there are no differences between both groups in terms of ccfDNA and ccfmiRNA concentration. The concentration of ccfDNA is significantly correlated with working time in the fluoroscopy field (p < 0.05). We found that the concentration of ccfmiRNA was significantly correlated with working time in plain radiography (p < 0.01) and computed tomography (p < 0.05) and with total working time (p < 0.01). Similarly, the concentrations of ccfRNA were significantly correlated with working time in computed tomography (p < 0.01) and with the total working time (p < 0.05) of the workers. We found that imaging number in computed tomography significantly altered the level of ccfRNA (p = 0.006) and that working time in the computed tomography field significantly affected the ccfRNA concentration (p = 0.03, R-2 =0.36 for model). Finally, we determined that total working time was significantly associated with total ccfRNA concentration (p < 0.05, R-2 =0.25 for model). In conclusion, total RNA measured in radiation-exposed workers has the potential to predict the radiation exposure risk. Furthermore, total working time and working time in the tomography field significantly alter the level of free nucleic acids.Öğe Fraser Syndrome: A Report of Two Cases(Galenos Yayincilik, 2015) Kilinc, Nihal; Demir, Sureyya; Demir, BulentFraser syndrome (cryptophthalmos syndactyly syndrome) is a rare autosomal recessive disorder. The main features are cryptophthalmos (hidden eye), ear, nose and skeletal malformations, syndactyly, laryngeal stenosis and malformation of the uro-genital system, lungs, liver, and the central nervous system. Renal anomalies (unilateral/bilateral agenesis) occur in 85% of cases. These anomalies were first documented by Fraser in 1962. In this paper, we present two cases of Fraser syndrome diagnosed after a normal spontaneous vaginal delivery without prenatal follow-up in the light of the literature.Öğe Patterns of Motor Branching of the Musculocutaneous Nerve in Human Fetuses and Clinical Significance(Wiley, 2011) Kervancioglu, Piraye; Orhan, Mustafa; Kilinc, NihalThe purpose of this morphologic study is to investigate the course and the branching pattern of motor branches of musculocutaneous nerve (MCN) in human fetuses. Twenty upper limbs (10 right, 10 left) of spontaneously aborted formalin-fixed fetuses were dissected under a stereomicroscope to determine motor branches for the biceps brachii and brachialis and the communicating branches between the MCN and median nerve (MN). The MCN entered the proximal and middle part of coracobrachialis in 13/20 and 5/20 of arms, respectively, and the remaining 2/20 did not pierce coracobrachialis. The communication between MCN and MN was observed in 5/20 of the arms and detected only in the distal part of the coracobrachialis. The most frequently observed innervation is the type wherein a single branch to biceps brachii, which bifurcated for supplying the short and long heads (12/20). For the innervation of brachialis, the most frequent type was a single branch from the main trunk of the MCN (15/20). During the dissections, the distance between the acromion and the emerging point of the motor branches was measured. The mean distance between the acromion and the emerging point of the all motor branches for biceps brachii in all types of specimens was 33.8 +/- 6.1% of acromion-lateral epicondyle length and for brachialis was 50.6 +/- 11.5% of acromion-lateral epicondyle length. The data of the MCN variations in the human fetus may be useful for the clinicians and pediatric surgery. Clin. Anat. 24:168-178, 2011. (C) 2011 Wiley-Liss, Inc.Öğe Quercetin associated with dimethylsulfoxide has a curative effect on experimental colon anastomosis injury(Acta Cirurgica Brasileira, 2020) Demir, Ufuk; Edremitlioglu, Mustafa; Kanda, Emel; Sehitoglu, Muserref Hilal; Kilinc, NihalPurpose: To examine the effects of quercetin on healing of experimental colon anastomosis injury in early and late period. Methods: Eighty male Wistar-Albino rats were divided into 8 groups. For all groups, left colons of the rats were resected and for the rest end-to-end anastomosis was performed. Two of the groups for which the experiment protocol was ended on the 3rd and 7th day following the anastomosis were not administered with either quercetin or dimethylsulfoxide DMSO, whereas two other groups were administered with DMSO only, and four other groups were administered with quercetin dissolved in DMSO in doses of 20 and 100 mg/kg during the protocol. At the end of the study, anastomosis line was resected, histopathological evaluation was performed and bursting pressure, malondialdehyde, superoxide dismutase, catalase, and hydroxyproline levels were measured. Results: Quercetin significantly increased hydroxyproline, superoxide dismutase, catalase levels, histopathological healing score, bursting pressure values and decreased malondialdehyde level in early period. It also significantly increased superoxide dismutase, catalase, and hydroxyproline levels and decreased malondialdehyde level in late period. Conclusion: it was seen that quercetin speeds up the injury healing process and reveals an antioxidant effect, specifically in early period.Öğe Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases(Marmara Univ, Fac Medicine, 2015) Kilinc, NihalObjective: This study explores the correlation between the expression of E-cadherin, p53 tumor suppressor gene, c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases. Patients and Methods: We have investigated tumor samples from sixty patients with invasive ductal breast carcinoma. 30 of the patients had axillary lymph node metastases and 30 had no axillary lymph node metastases. Tumor tissues of these patients were evaluated by immunohistochemistry for E-cadherin, p53, c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR). Results: E-cadherin staining was not expressed in 39 patients (65%) with invasive ductal breast carcinoma. ER, PgR, p53, and c-erb-B2 signals were positive in 36 (60%), 26 (43.3%), 33 (55%), and 29 (48.3%) of the patients, respectively. PgR and c-erb-B2 expression was associated with lymph node metastases (p=0.009, p=0.001, respectively). No association was found between the reduced E-cadherin protein and age. The presence of E-cadherin was associated with axillary lymph node metastases and p53 (p<0.009, p<0.001, respectively). Conclusion: We found that, the p53 protein may play a role in regulation of E-cadherin protein expression in invasive ductal breast carcinomas with axillary lymph node metastases.Öğe The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model(Taylor & Francis Inc, 2015) Ercan, Umut; Kiraz, Asli; Cikman, Oztekin; Turkon, Hakan; Kilinc, Nihal; Otkun, Muserref Tatman; Ozkan, Omer FarukAim: This study aimed to investigate the effects of L-carnitine, with its known antioxidant properties and positive effects on wound healing, on the healing of colon anastomosis in a cecal ligation and puncture sepsis model in rats.Materials and Methods: A total of 40 Sprague-Dawley rats were used. The rats were randomly divided into four groups of 10 (n = 10). Groups 1 and 2 had laparotomy and colon anastomosis performed. Groups 3 and 4 had cecal ligation and puncture (CLP) and colon anastomosis performed. Rats in Groups 1 and 3 were given 15mL/kg intraperitoneal 0.9% isotonic NaCl, while the rats in Groups 2 and 4 were given 100mg/kg intraperitoneal L-carnitine. On the postoperative fifth day, the rats were sacrificed and the burst pressure of anastomosis, histopathological effects, and tissue hydroxyproline levels were investigated.Results: In Groups 2 and 4, the anastomosis burst pressure and histopathological results in both noninfected abdomen and presence of peritonitis were statistically high compared to the control group (p < 0.05). Though the hydroxyproline levels were also high, there was no statistically significant difference for this parameter (p > 0.05).Conclusions: The findings obtained from the experimental sepsis model showed that healing of anastomosis in both the presence of peritonitis and noninfected abdomen was positively affected by the systemic administration of L-carnitine and this may contribute to the safety of anastomosis.Öğe The Inevitable Outcome of Chronic Recurring Actinomyces Osteomyelitis of The Hand(Galenos Publ House, 2015) Golge, Umut Hatay; Goksel, Ferdi; Komurcu, Erkam; Kaymaz, Burak; Kilinc, Nihal[Anstract Not Available]Öğe Unusual cases of necrotizing fasciitis: a clinical experience from Turkey(Springer, 2018) Kapi, Emin; Dogan, Zeynep Deniz Akdeniz; Seyhan, Tamer; Kilinc, NihalBackground Necrotizing fasciitis is a rare, destructive soft tissue infection which starts on the skin and subcutaneous tissue, and spreads quickly towards the deeper tissues. Its etiology includes trauma, surgical intervention, perineal abscess, soft tissue infection, minor invasive procedures, abrasion, contusion, burn, laceration, bite, and penetrating injuries. The mortality of the disease can increase in the presence of predisposing factors such as diabetes, hypertension, immunodeficiency, self-care insufficiency, alcoholism, and advanced age. The clinical presentation of necrotizing fasciitis may vary. It is often observed in the abdominal region, the lower extremity, the perineal, perianal, scrotal and genital regions. Methods Between December 2011 and September 2016, a retrospective study of all patients admitted due to necrotic wounds and/or tissue defects was undertaken. Their clinical records were reviewed with respect to age, sex, associated morbidities, defect localization, treatment, and outcomes. Results Thirteen cases were admitted to the emergency department. There were 10 female and 3 male patients. The defects were located in the gluteal (one), trochanteric (one), thoracic (two), upper extremity (three), lower extremity (two) and perineal region (four). Pressure sores, insect bites, trauma, diabetes mellitus and perineal infections were detected in the etiology of the cases. As observed in our study, NF can present with very different etiological, demographical and clinical findings. Conclusions The cases presented some rarely observed characteristics in terms of age, sex, etiology, and infection localization. Therefore, it should be kept in mind that necrotizing fasciitis can exhibit extraordinary characteristics causing confusion with other soft tissue infections, and a detailed and meticulous evaluation must be performed for diagnosis. y
