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    Histopathological Evaluation of the Polyps with and without the Presence Cholesteatoma
    (Aves, 2010) Baylan, Muzeyyen Yildirim; Koc, Ersar Evren; Kilic, Nihal; Meric, Faruk
    Objective: To determine if there were any differences between the histopathological structures of the polyps with or without cholesteatoma Materials and Methods: In our study, 41 patients underwent operation with complaints of chronic otitis media with polyp. The patients were divided into those who had cholesteatoma and those who did not, so that discriminatory features were identified. Chronic otitis media with polyp was associated with cholesteatoma in 21 patients. Cholesteatoma was not found in 20 patients with chronic otitis media with polyp. Specimens removed from the both of patients groups were evaluated and compared between the groups in according to histopathologic features. Results: We observed that specimens of polyps with cholesteatoma were comprised of keratinized masses, keratinized tissue layers, and abundant immature granulation tissue, whereas, specimens of the polyps without cholesteatoma consisted of copious glandular stroma bordered by smooth epithelium (p<0,05). Conclusion: Our study showed that histopathologic features of the polyps suggest the presence or absence of cholesteatoma.
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    Öğe
    The effect of Tannic acid on colonic anastomosis in abdominal sepsis: An experimental study
    (Public Library Science, 2025) Cikman, Oztekin; Tas, Sukru; Ozkan, Omer Faruk; Ercan, Umut; Turkon, Hakan; Kilic, Nihal; Akgun, Yilmaz
    Background This study aimed to evaluate the effect of tannic acid on colonic anastomosis in a sepsis model induced by cecal abrasion.Materials and methods Thirty Sprague-Dawley rats were used. The animals were randomly divided into three groups of ten: Group 1 (n:10): Colonic anastomosis + 0.9% isotonic NaCl. Group 2 (n:10): Cecal ligation and puncture + Colonic anastomosis + 0.9% isotonic NaCl. Group 3 (n:10): Cecal ligation and puncture + Colonic anastomosis + Tannic Acid group. The rats were sacrificed on the fifth postoperative day, and the resected colon segments, bursting pressure, hydroxyproline levels, and histopathologic features of the anastomosis were evaluated.Results The bursting pressure value was statistically significantly higher in Group 3, where tannic acid was administered (p < 0.05). Group 2 and Group 3, in which peritonitis was induced, had moderate levels of fibroblastic activity, inflammatory cell infiltration, neovascularisation, and collagen; whereas, they were higher in Group 1. Although the inflammation value dropped in Group 3 compared to Groups 1 and 2, there was no statistical difference in Group 2. The hydroxyproline values were 2.046 +/- 1.1411 mcg/gr and 5.9730 +/- 4.35900 mcg/gr tissues, respectively, in Groups 2 and 3, where septic conditions prevailed, and a statistically significant difference was found (p < 0.05).Conclusion This experimental study revealed that the use of tannic acid during anastomosis has a positive effect on wound healing, acting through higher colonic anastomotic bursting pressures and higher tissue hydroxyproline levels.