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    A critical review of molecularly imprinted polymer technology for aflatoxin sensing: Current status and future directions
    (Elsevier, 2026) Cetinkaya, Ahmet; Kaya, S. Irem; Demirbakan, Burcak; Unal, Mehmet Altay; Sezginturk, Mustafa Kemal; Ozkan, Sibel A.; Altuntas, Evrim Gunes
    Since the first discovery and identification of aflatoxins almost 70 years ago, their occurrence, potential risks, and health hazards remain of great importance. Therefore, several chromatography-, colorimetry-, and immunoassay-based analytical applications for aflatoxin detection are reported in the literature. Molecularly imprinted polymers (MIPs) have attracted considerable interest in sensor design due to their unique potential as synthetic recognition elements, providing high selectivity and excellent stability. These features help overcome the disadvantages of conventional sensing systems. The ongoing advancement of MIP-based sensors presents new opportunities for future applications and offers a reliable and versatile approach to meet the growing demands of current analytical research. This review focuses on studies published since 2023 concerning the detection of aflatoxins using MIP-based sensors, which hold a prominent and critical position in the literature. Additionally, this review addresses several limitations of MIP-based sensors, particularly in the context of aflatoxin detection, and discusses proposed solutions to overcome these challenges. Lastly, current advancements and future expectations in the topic are also highlighted.
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    Lateral flow assays for hormones
    (Elsevier, 2025) Cetinkaya, Ahmet; Kaya, S. Irem; Uludağ Anıl, İnci; Kemal Sezgintürk, Mustafa Kemal; Ozkan, Sibel A.
    Hormones are biological entities that are released by endocrine glands or tissues, and the critical metabolic and physiological pathways of the body require various hormones. Blood levels of hormones in an individual are important indicators of healthy or abnormal conditions. Accurate, rapid, and sensitive determination of the concentrations of hormones, which are usually at the picomolar-nanomolar level, is critical in health applications. In addition to this, it may also be possible to aim to increase efficiency and promote growth by adding steroid hormones to foods inappropriately. Detection of hormone residues in foods is also important to prevent situations that threaten food safety and human health. Lateral flow assays (LFAs) are advantageous, paper-based analysis platforms in which separation and selectivity features are integrated. LFAs are advantageous, paper-based analysis platforms in which separation and selectivity features are integrated. LFA design includes parts such as the bioreceptor, control zone, etc., and detection methods such as colorimetry or fluorescence can be used. In this chapter, the applications of LFAs in the health field for purposes such as diagnostics or monitoring of a condition and their use in food safety are examined. After giving information about the design of a standard LFA and the assay procedure, current studies containing the most important applications in hormone determination were evaluated in terms of target hormone, assay type, label, detection method used in LFA, linear range, limit of detection, examined sample, and recovery% value. While the current status of LFAs on a critical issue, such as hormone analysis, is discussed in detail, the future course is also evaluated. © 2026 Elsevier Inc. All rights reserved..
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    Lateral flow assays in food analysis
    (Elsevier, 2025) Kaya, S. Irem; Cetinkaya, Ahmet; Kemal Sezgintürk, Mustafa Kemal; Ozkan, Sibel A.
    The intricacy of the global food systems has led to a focus on food safety and authentication, and food safety is a serious concern at every stage of manufacturing because foodborne microorganisms have a negative effect on human health. Furthermore, the presence of chemicals, drugs, heavy metals, microbial pathogens, mycotoxins, pesticides, and other potentially hazardous substances in food products poses a threat to food safety. Therefore, it is vital to develop a reliable and user-friendly tool to assess food quality. Traditional approaches to determining substances affecting seed safety in food analysis, like chromatographic techniques (high-performance liquid chromatography and gas chromatography), immunoassay techniques (enzyme-linked immunosorbent assay), polymerase chain reaction, mass spectrometry, and surface-enhanced Raman scattering are time-consuming, labor-intensive, and expensive, which makes them unsuitable for on-site use. The need for quick and easy methods for food safety has increased due to recurrent outbreaks of foodborne illness. Lateral flow assays (LFA) have gained popularity recently due to their on-site, low-cost, and quick pathogen detection capabilities. Here, recent advances in LFAs for detecting various food safety threats in food samples were examined, and the advantages and disadvantages of LFA performance were highlighted. In addition, the advantages and disadvantages of LFAs in food analysis, as well as future trends, will be discussed. The primary obstacles to the continued advancement of LFA platforms were explained, and LFAs could soon provide exceptional performance at the point of care that can compete with laboratory methods. © 2026 Elsevier Inc. All rights reserved..