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Öğe Arginine vasopressin and difficult triangle of heart failure, atrial fibrillation, and hyponatremia(Hellenic Cardiological Soc, 2020) Kaya, Hakki; Cavusoglu, Yuksel[Anstract Not Available]Öğe Association between stasis dermatitis and length of stay in heart failure hospitalizations(Wolters Kluwer Medknow Publications, 2020) Kaya, Ozge; Sahin, Anil; Kaya, HakkiBackground: Stasis dermatitis (SD) is caused by venous hypertension that can be associated with peripheral congestion due to heart failure (HF). Length of stay (LOS) is the primary driver of HF hospitalization costs. Therefore, it is important to determine those patients who will have longer LOS. We aimed to investigate the relationship between the SD and LOS in HF patients. Methods: A total of 308 patients, who were hospitalized between January 2012 and January 2014 due to acute decompensated HF (ADHF) in our center, were evaluated in this retrospective observational cohort study. Patients' baseline clinical characteristics and presence of SD diagnosis within the past 3 months prior the HF hospitalization were assessed by a review of cardiology and dermatology clinics medical records. Results: A total of 237, acutely decompensated, HF patients were enrolled in the study. The median LOS was 5 days, and the mean LOS was 5.4 ± 2 days. Prolonged LOS was defined as LOS >5 days, and the patients were classified into two groups: Those with LOS ?5 days (Group I) and those with LOS >5 days (Group II, longer LOS). The presence of SD diagnosis was higher in Group II compared to patients in Group I (22% vs. 46%, P < 0.001). In the multivariate logistic regression model, presence of SD diagnosis, presence of moderate-to-severe tricuspid regurgitation, presence of atrial fibrillation, left atrial diameter, creatinine level, sodium level remained associated with longer LOS after adjustment for age, gender and for the variables found to be statistically significant in univariate analysis and correlated with LOS. Conclusions: This was the first time in the literature that a study demonstrated that the presence of SD was associated with an increased the risk of prolonged hospitalization independent of other factors in patients with reduced ejection fraction heart failure admitted for ADHF. © 2020 Society of Cardiovascular Academy. All rights reserved.Öğe EPICARDIAL FAT THICKNESS INCREASE IN PATIENTS WITH SEBORRHEIC DERMATITIS AS A CLINICAL BIOMARKER OF CARDIO-METABOLIC RISK(Termedia Publishing House Ltd, 2023) Kaya, Ozge; Kaya, HakkiBackground. Seborrheic dermatitis (SD) can be associated with cardiometabolic conditions. This study aimed to evaluate epicardial fat thickness (EFT), a marker of cardiometabolic disease, in SD patients.Material and methods. In this cross-sectional and observational study, 90 patients with SD and 50 age-and sex-matched control subjects were evaluated for echocardiographic EFT and metabolic profile data.Results. Systolic blood pressure, heart rate, high sensitive C-reactive protein, monocyte count and EFT were found to be significantly higher in the SD group (53 female; mean age, 39.3 +/- 13.3 years) compared to the control group (34 female; mean age, 39.9 +/- 13.4 years). In the multivariate logistic regression analysis, the EFT and heart rate were found to be independently associated with SD. Additionally, in the multivariate linear regression analysis including the parameters correlated with EFT and the parameters associated with EFT at the p<0.001 level in univariate analysis; BMI (beta: 0.341, p<0.001) and SD disease duration (beta: 0.435, p<0.001), as well as seborrheic dermatitis area and severity index (beta: 0.177, p=0.037) were found to be independently associated with EFT.Conclusions. EFT is increased in patients with SD and was also found to be independently associated with SD. Prolonged and severe SD may be a dermatological sign regarding cardiometabolic disease.Öğe Gender-Related Differences in Patients with Acute Heart Failure: Observation from the Journey Heart Failure-Turkish Population Study(Kare Publ, 2023) Akcay, Filiz Akyildiz; Sinan, Umit Yasar; Gurbuz, Dogac Caglar; Safak, Ozgen; Kaya, Hakki; Yuksek, Umit; Zoghi, MehdiBackground: Gender-related clinical variations in patients with acute heart failure have been described in previous studies. However, there is still a lack of research on gender differences in patients hospitalized for acute heart failure in Turkiye. The aim of this study is to compare the clinical features, in-hospital approaches, and outcomes of male and female patients hospitalized for acute heart failure. Methods: Differences in clinical characteristics, medication prescription, hospital management, and outcomes between males and females with acute heart failure were investigated from the Journey Heart Failure-Turkish Population study. Results: Nine hundred eighteen patients (57.2%) were men and 688 (42.8%) were women. Women were older than men (70.48 +/- 13.20 years vs. 65.87 +/- 12.82 years; P <.001). The frequency of comorbidities such as hypertension (72.7% vs. 62.4%, P <.001), diabetes (46.5% vs. 38.5%, P =.001), atrial fibrillation (46.5% vs. 33.4%, P <.001), New York Heart Association class III-IV symptoms (80.6% vs. 71.2%, P =.001), and dyspnea in the rest (73.8% vs. 68.3%, P =.044) were more common in women on admission. Male patients were more frequently hospitalized with reduced left ventricular ejection fraction (51.0% vs. 72.4%, P <.001). In-hospital mortality was higher among female patients (9.3% vs. 6.4%, P =.022). Higher New York Heart Association class, lower estimated glomerular filtration rate, higher N-terminal pro-B type natriuretic peptide on admission, and mechanical ventilation usage were the independent parameters of in-hospital mortality, whereas the female gender was not. Conclusion: Our study clearly demonstrated the diversity in presentation, management, and in-hospital outcomes of acute heart failure between male and female patients. Although left ventricular systolic functions were better in female patients, in-hospital mortality was higher. Recognizing these differences in the management of heart failure in different sexes will serve better results in clinical practice.Öğe Olfactory dysfunction may predict myocardial injury in COVID-19 patients(Churchill Livingstone, 2020) Aksit, Ercan; Cil, Ozge Caglar; Kaya, Hakki[Anstract Not Available]Öğe Relationship between sST2 levels and prognosis in patients with pulmonary arterial hypertension(Bayrakol Medical Publisher, 2020) Sahin, Anil; Kaya, Hakki; Gul, IbrahimAim: Soluble Suppression of Tumorigenicity-2 (sST2) was approved for non-invasive risk assessment and its prognostic benefits were monitored in some heterogeneous pulmonary hypertension cohorts. In this study, we aimed to evaluate the relationship of sST2 use with clinical deterioration and survival in pulmonary arterial hypertension (PAH) patients. Material and Method: Forty-one patients (36 women, 5 men) who were followed due to known PAH were included in the study. The primary endpoint was determined as clinical deterioration. Results: At the end of the mean 6 +/- 2 months follow-up period, in total, 14 patients (34%) exhibited clinical deterioration and 7 patients (17%) died. Patients having WHO-FC III-IV, high sST2, and NT-proBNP levels and low 6-MWT presence were associated with clinical deterioration (p<0.001). Also, sST2 and NT-proBNP levels were significantly higher in patients who died during follow-up (p=0.004 and p=0.003, respectively). In the multivariate Cox proportional hazards model with the forward stepwise method, TAPSE (HR=0.587, 95% CI: 0.419-0.823, p=0.002) and sST2>51 ng/ml on admission (HR=9.653, 95% CI: 4.074-82.249, p=0.004) remained associated with an increased risk of clinical deterioration. Discussion: This study shows that sST2 levels can provide some information in determining clinical impairment in PAH patients. This is compatible with previous studies showing high levels of sST2 in PAH patients. sST2 levels were shown to be an independent predictor of clinical deterioration on PAH.Öğe The Significant Role of Post-Acute Care Programs in Individuals with Heart Failure(Taiwan Soc Cardiology, 2024) Aksit, Ercan; Kaya, Hakki; Gazi, Emine[Anstract Not Available]
