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Öğe AN INTERESTING AND RARE COINCIDENCE IN CORONARY ARTERY DISEASE(Elsevier Ireland Ltd, 2013) Köleoğlu, M.; Köroğlu, S.; Suner, A.; Nacar, A.; Kaya, H.; Altun, B.; Aksu, E.[Anstract Not Available]Öğe Effects of dietary diludine supplementation on growth, proximate composition, muscle and texture structure of rainbow trout juveniles(Iranian Fisheries Science Research Inst-Ifsri, 2018) Hisar, O.; Karaoglu, M. M.; Hisar, S. A.; Yanik, T.; Gurkan, M.; Kaya, H.A feeding trial which lasted for eight weeks was conducted to investigate the effects of diludine, a growth promoter, on feed efficiency, muscle structure and proximate composition of juvenile rainbow trout. Diludine was added at 0.0(D-0) 0.2(D-1), 0.5(D-2) and 1(D-3) g kg(-1) to a casein-based diet, and every diet was given to the triplicated groups of juvenile rainbow trout. At the end of experiment, it was determined that a significant improvability existed for both growth and feed utilization in fish fed diets supplemented with diludine (p<0.05). Similarly, different concentrations of diludine affected the densitometric quantification of myofibrillar proteins in fish muscle according to results obtained by Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The mean value of fiber diameters significantly increased in skeletal muscle with increasing concentrations of diludine. The histological results also showed hypertrophic adipocytes in skeletal muscle of fish fed D-2 and D-3 diets. The lowest elasticity values were observed in fish fed the control diet while those fed D-3 diet had highest elasticity values. On the other hand, no differences were found between fish fed experimental diets in terms of survival rate and all fish exhibited similar proximate composition for protein, lipid, moisture and ash. Consequently, it may be suggested that dietary diludine supplementaion up to 1 g kg(-1) concentration in the diets have positive impacts on growth of rainbow trout juvenils and the better growth in the fish fed with diludine supplements could be arise from muscle characteristics, in particular changes in fibres than proximate composition of the muscles.Öğe Effects of lead nitrate on haematological and immunological parameters in the tilapia (Oreochromis mossambicus, L. 1758)(Elsevier Ireland Ltd, 2011) Kaya, H.; Akbulut, M.; Celik, E. S.; Yilmaz, S.; Aydin, F.; Duysak, M.[Anstract Not Available]Öğe Environmental changes based on multi-proxy analysis of core sediments in Lake Aktas, Turkey: Preliminary results(Pergamon-Elsevier Science Ltd, 2018) Kilic, Nurgul Karlioglu; Caner, Hulya; Erginal, Ahmet Evren; Ersin, Sinem; Selim, H. Haluk; Kaya, H.A sediment core covering the last millennium from Lake Aktas, a shallow alkaline soda lake in the northeast Anatolian highland of Turkey, was studied for pollen and physical and chemical proxies to reconstruct past climate change. The sediments were dated by AMS radiocarbon dating of bulk organic carbon. Among arboreal pollen (AP) from around 930 years ago, dominant trees were Pinus sylvestris, Picea orientalis, Abies, Betula, Fagus, and Quercus. AP exceeded NAP (non-arboreal pollen) in this time, whereas the opposite is the case in a pollen trap in the same region collecting the pollen for one year in 2015-2016. The comparison of modern and fossil pollen influx indicates that in that period trees were more widely distributed around the lake than today, where steppe vegetation now prevails. Inferred causes for the disappearance of trees are anthropogenic impacts and climatic change towards more continental conditions. The results also identify the onset of the Little Ice Age in the NE Anatolian highland of Turkey. (C) 2018 Elsevier Ltd and INQUA. All rights reserved.Öğe HEART RATE VARIABILITY IN FAMILIAL MEDITERRANEAN FEVER PATIENTS(Elsevier Ireland Ltd, 2013) Suner, A.; Kaya, H.; Köroğlu, S.; Akçay, A.; Sayarlıoğlu, M.; Köleoğlu, M.; Altun, B.[Anstract Not Available]Öğe Hyperkalemia in heart failure patients with renal dysfunction in real life clinical practice: Results from TREAT HF Study(Wiley, 2020) Cavusoglu, Y.; Kaya, H.; Murat, S.; Yilmaz, M. B.[Anstract Not Available]Öğe Influence of Tribulus terrestris extract on the survival and histopathology of Oreochromis mossambicus (Peters, 1852) fry before and after Streptococcus iniae infection(Wiley, 2014) Yilmaz, S.; Ergun, S.; Kaya, H.; Gurkan, M.The aim of this study was to determine the effects of Tribulus terrestris extract (TT) on growth performance, disease resistance and histopathological changes in intestine and liver tissues of Oreochromis mossambicus (Peters, 1852) first-feeding fry before and after exposure to Streptococcus iniae. Five iso-nitrogenous and isocaloric diets were formulated to contain 0 (control), 200, 400, 600, and 800 mg kg(-1) TT. After feeding for 45 days, fish were infected with S. iniae and mortalities recorded. Final weight, weight gain and SGR of tilapia fry fed the 400 mg kg(-1) TT diet were significantly greater than that of control diet. In the challenge experiment, the best survival rate was obtained with 400 mg kg(-1) TT supplementation. Infection by S. iniae appeared to have a negative effect on histopathological findings and outcome than did TT-800 used alone. However, administration of TT (200 or 400 mg extract kg(-1)) resulted in overall improvement in the intestine and liver histopathology, emphasizing the protective potential of TT. The present study suggests the protective potential of TT in alleviating intestinal and hepatic damage that can occur after a S. iniae infection. It was concluded that 400 mg kg(-1) TT can enhance growth and disease resistance during first-feeding of O. mossambicus fry. This suggests that TT may be an alternative to antibiotics in controlling streptococcal disease in tilapia culture.Öğe Is bendopnea associated with atrial fibrillation in heart failure patients with reduced ejection fraction?(Wiley, 2023) Sahin, A.; Oztekin, G. M. Yilmaz; Genc, A.; Kaya, H.; Yilmaz, M. B.[Anstract Not Available]Öğe Is elabela/toddler a poor prognostic marker in heart failure patients?(Lithographia, 2023) Kucuk, U.; Kirilmaz, B.; Kaya, H.; Aksit, E.; Arslan, K.Background: Elabela/toddler (ELA-32) is a recently identified endogenous apelin receptor ligand. ELA levels are known to rise in heart failure (HF) patients. However, the association between elevated ELA levels and prognosis in these patients remains unknown. We aimed to investigate whether ELA plasma levels are correlated with prognosis in heart failure patients with reduced ejection fraction (HFrEF). Methods: This case-control cross-sectional study enrolled 150 patients, including 73 HFrEF patients and 77 age- and gender-matched healthy volunteers. We collected a blood sample at hospital admission to measure ELA-32 levels. The study endpoint was cardiovascular mortality or HF-related hospitalization. We followed up all patients in the study for a mean of 7.48 +/- 2.73 months. Results: In patients with HFrEF, ELA-32 levels were higher than those in controls. The levels of ELA-32 showed a significant increase at advanced New York Heart Association stages. In the receiver operating characteristics curve analysis, a cut-off value of the serum ELA-32 level of 8.25 ng/mL showed a sensitivity of 76 % and specificity of 82 % for predicting the study endpoint [area under the curve: 0.84; 95 % confidence interval (CI): 0.72-0.98; p <0.001]. Cardiovascular mortality (p =0.042) and HF-related hospitalization (p <0.001) were statistically more significant in patients with ELA-32 levels greater than 8.25. Age [Hazard ratio (HR) =1.023; 95 % CI: 0.964-1.230, p =0.039], N-terminal =1.142; 95 % CI 1.022-1.547, p =0.028), and ELA-32 >= 8.25 (HR =2.556; 95 % CI: 1.078-3.941, p <0.001) remained independently associated with the risk of study endpoint. Conclusion: For the first time, HF-related hospitalizations and cardiovascular mortality are independently associated with increased ELA-32 levels in patients with HFrEF. HIPPOKRATIA 2023, 27 (4):126-131.Öğe Monitoring of trace metals, biochemical composition and growth of Axillary seabream (Pagellus acarne Risso, 1827) in offshore copper alloy mesh cages(Natl Centre Marine Research, 2016) Yigit, M.; Celikkol, B.; Bulut, M.; Decew, J.; Ozalp, B.; Yilmaz, S.; Kaya, H.The study was conducted to assess trace metal contents, biochemical composition and growth performance of axillary seabream (Pagellus acarne Risso, 1827) cultured in a copper alloy mesh cage. A total of 400 axillary seabream (initial mean weight: 176.0 +/- 14.0 g), a new candidate species for the Mediterranean aquaculture, were stocked into a high-density polyethylene frame gravity cage and fed a commercial seabream diet for a period of 6 months. At the end of the feeding trial, fish reached a final weight of 264.8 +/- 16.8 g with a weight increase of 88.8 g and a feed conversion rate of 2.51. Overall, relative growth rate, specific growth rate and feed conversion ratio were satisfactory and comparable to the pelagic fishes such as gilthead seabream or European seabass, which are presently the main fish species for the Mediterranean aquaculture industry. Trace elements in fish grown in copper alloy net cages over a 6-month period showed satisfactory results, as the metal concentrations in fish tissues such as liver, skin, muscle and gills were below the reported upper limits for human consumption, indicating that copper alloy net is an acceptable and safe material for finfish cage aquaculture. Furthermore, from the growth performance data obtained in the present study, it can be concluded that axillary seabream showed potential for cage farming, and thus is a promising new candidate for the Mediterranean aquaculture industry.Öğe Potantial clinical application of potassium binders in patients with chronic heart failure in real life clinical practice: results from TREAT HF study(Oxford Univ Press, 2020) Cavusoglu, Y.; Kaya, H.; Murat, S.; Yilmaz, B.[Anstract Not Available]Öğe Potential clinical application of dapagliflozin in patients with chronic heart failure in real life clinical practice: Results from TREAT HF Study(Wiley, 2020) Cavusoglu, Y. Yuksel; Kaya, H.; Yilmaz, M. B.[Anstract Not Available]Öğe Prevalence of hyperkalemia in patients with chronic heart failure in real life clinical practice: Results from TREAT HF Study(Wiley, 2020) Cavusoglu, Y.; Kaya, H.; Murat, S.; Yilmaz, M. B.[Anstract Not Available]Öğe Protective effect of an L-type calcium channel blocker, amlodipine, on paracetamol-induced hepatotoxicity in rats(Sage Publications Ltd, 2018) Kaya, H.; Polat, B.; Albayrak, A.; Mercantepe, T.; Buyuk, B.Paracetamol (P), one of the most popular and commonly used analgesic and antipyretic agents, causes hepatotoxicity in overdoses. Amlodipine (AML), an L-type calcium channel blocker, has been shown to have anti-inflammatory activity by reversing the effect of calcium in the inflammation pathogenesis. In this study, the hepatoprotective activity of AML on P-induced hepatotoxicity was evaluated. Thirty male albino Wistar rats were divided into five groups: (1) control, (2) 2 g/kg of P, (3) 2 g/kg of P + 5 mg/kg of AML, (4) 2 g/kg of P + 10 mg/kg of AML, and (5) 10 mg/kg of AML. Some liver enzymes, oxidative parameters, cytokine mRNA expressions, histopathology, and immunohistochemical studies were performed in liver and blood samples. The serum levels of alanine aminotransferase and aspartate aminotransferase and the mRNA expression of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta in the liver tissues were significantly increased in the group treated with P. The superoxide dismutase and glutathione parameters decreased and malondialdehyde levels increased in the livers of the rats treated with P. All these parameters were increased with both doses of the AML similar to the control group. A histopathological examination of the liver showed that AML administration ameliorated the P-induced inflammatory liver damage. In immunohistochemical staining, the expression of TNF-alpha in the cytoplasm of the hepatocytes was increased in the P group but not in other treatment groups when compared to the control. In conclusion, AML treatment showed significant protective effects against P-induced hepatotoxicity by increasing the activity of antioxidants and reducing inflammatory cytokines.Öğe Radiodiagnostic examination of common carp (Cyprinus carpio, L. 1758) vertebra exposed to phosalone(Elsevier Ireland Ltd, 2011) Kaya, H.; Celik, E. S.; Akbulut, M.; Yilmaz, S.; Aydin, S.; Duysak, M.; Aydin, F.[Anstract Not Available]Öğe Stasis dermatitis: A skin manifestation of poor prognosis in patients with heart failure(Lithographia, 2022) Kaya, O.; Kaya, H.Background: The relationship between stasis dermatitis (SD), clinical factors, and heart failure (HF) outcomes in outpatients has not been previously assessed. Methods: This observational cross-sectional study evaluated 324 patients admitted to the HF outpatient clinic. A total of 158 HF outpatients (100 males and 58 females) were enrolled in the study and were divided into two groups depending on whether they were diagnosed with SD within six months before attending the outpatient clinic. Forty-one patients (26 %) diagnosed with SD in the preceding six months were designated group 1, and 117 (74 %) not diagnosed were designated group 2. Results: Diabetes mellitus (DM) (OR =5.473, p <0.001), chronic obstructive pulmonary disease (COPD) (OR =2.623, p =0.039), and increased systolic pulmonary artery pressure (SPAP) (OR =1.061, p =0.001) values were independently associated with SD in multivariate logistic regression analysis. During the follow-up of 12 +/- 4 months, no significant difference was documented between group 1 and group 2 regarding the death ratio (17 % vs. 19 %, p =0.991). In the multivariate Cox proportional-hazards model with a stepwise forward method, the presence of SD diagnosis [hazard ratio (HR) =2.933, 95 % Confidence Interval (CI): 1.660-5.181, p <0.001] and coronary artery disease (CAD) (HR=2.492, 95%CI: 1.238-5.018, p= 0.011) remained independently associated with the risk of HF-related hospitalization. Conclusion: SD was found, for the first time, to be independently associated with DM, COPD, and increased SPAP values and determined as an independent predictor for HF-related hospitalization.
