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    A Reason of Delayed Weaning in Critical Care: Amiodarone Pulmonary Toxicity
    (2017) Öterkuş, Mesut; Tezcan, Aysu Hayriye; Dönmez, İlksen; Karayol, Sunay Sibel; Öztürk, Ömür
    Amiodarone is a frequently used antiarrhythmic drug in criticalcare which was used to treat especially ventricular arrhythmias.But it must known that secondary to its chemical properties, drugtends to accumulate in tissues and it presents as cardiac, ophtalmic,pulmonary and neurological side effects. Amiodarone pulmonarytoxicity (APT) is one of the life-threatening side effects ofthe drug which may present as respiratory failure. And thorax computedtomography scans demonstrate the pathology with pneumonitis,groung glass opacities and fibrosis. Dispnea and coughare common clinical presentations. But an intubated and mechanicallyventilated patient’s respiratory failure secondary to APT mayreflect as only delayed weaning as in our case. Most importantly,rapid diagnosis and early treatment are the most important factorsthat reduce the mortality of patients.
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    Comparison of tru-cut biopsy and fine-needle aspiration cytology in an experimental alcoholic liver disease model
    (Assoc Medica Brasileira, 2020) Adali, Yasemen; Eroglu, Huseyin Avni; Makav, Mustafa; Karayol, Sunay Sibel; Guvendi, Gulname Findik; Gok, Mustafa
    INTRODUCTION: Liver biopsies such as tru-cut (sharp needle) and fine-needle aspiration cytology (FNAC) are the most commonly preferred techniques to detect the grade and stage of certain liver diseases. In this study, we aimed to compare the efficiency of USG-guided tru-cut biopsy and fine-needle aspiration cytology in an experimental alcoholic liver disease model. METHODS: Thirty-six female Wistar albino rats, 4-6 months old, and weighing from 190 to 250 g, were used in this study. The animals were randomly divided into six equal groups: GI (control), G2 (tru-cut control), G3 (FNAC control), G4 (Alcoholic liver disease model), G5 (Alcoholic liver disease model + FNAC), and G6 (Alcoholic liver disease model + tru-cut biopsy). After a histopathological evaluation by light microscopy, the sensitivity, specificity, positive and negative predictive values of FNAC and tru-cut biopsy for the diagnosis of liver lesions were calculated. RESULTS: No pathology was detected in GI except for mild congestion. On the other hand, hepatocyte damage, periportal inflammation, congestion, and fatty changes were detected in all liver tissues of the alcoholic liver disease groups. The sensitivity of hepatocyte damage, inflammation, congestion, and fatty change parameters for FNAC were 33.3%, 80%, 0%, and 0%, respectively, while the sensitivity of the same variables for tru-cut were 66.7%, 40%, 100%, and 20%, respectively. DISCUSSION: Both techniques were superior in some aspects. FNAC can be an attractive alternative to tru-cut biopsy and applied in routine practice in the diagnosis of non-tumoral liver diseases.
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    Fine Needle Aspiration Cytology (FNAC) vs. Tru-cut Biopsy in Liver with Iron Overload: An Experimental Study
    (2023) Adalı, Yasemen; Eroğlu, Hüseyin Avni; Makav, Mustafa; Karayol, Sunay Sibel; Güvendi, Gülname Fındık; Gök, Mustafa
    Objective: Fine needle aspiration cytology (FNAC) is safer, simpler, faster and cost effective, compared to tru-cut biopsy, and patient compliance is generally better. There is not much data on the use of FNAC, which is used in many organs and lesions, in parenchymal diseases in the liver. Therefore, in this study, the benefit of FNAC in showing iron deposition and injury of liver is evaluated. Methods: There were 2 control groups in the study. At the end of the study, FNAC and tru-cut biopsy samples were taken from these groups, where no administration was performed. FNAC and tru-cut biopsy procedures were also performed to the study groups after the iron overload was created by intraperitoneal iron dextran (88 mg/kg) administration for 28 days. Hepatocyte injury, inflammation and iron deposition were evaluated histopathologically in the preparations. The sensitivity, specificity, positive and negative predictivity and diagnostic accuracy of both methods were calculated based on the hepatectomy material. Results: In hepatocyte injury; sensitivity (60%), diagnostic accuracy (66.7%) and negative predictivity (50%) were found to be significantly higher in tru-cut group. It was observed that the methods were not superior to each other in the evaluation of inflammation, and FNAC almost approached tru-cut biopsy rates (100%) with a sensitivity of 83.3% and diagnostic accuracy in iron deposition. Conclusion: In iron-induced liver damage, the gold standard should be tissue examination, so tru-cut biopsy must be the first choice. However, based on the present study results, it is suggested that FNAC may be preferred over more invasive options in cases where tru-cut biopsy can not be used in terms of susceptibility to bleeding, situations where surgical accessibility is not available, patient orientation and cooperation is poor, or in presence of different accompanying diseases.
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    Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma
    (2019) Eroğlu, Hüseyin Avni; Karayol, Sunay Sibel; Güvendi, Bülent; Adalı, Yasemen
    Introduction: Due to the well-known relationship between inflammatory processes and carcinogenesis, the diagnostic and prognostic value of systemic inflammatorymarkers are at the focus of research. This study aimed to investigate the predictive value of inflammatory cell data obtained from complete blood count in incidentallydetected thyroid papillary carcinoma.Methods: A total of 100 cases were included in the study, consisting of histopathologically diagnosed multinodular hyperplasia (MNH) (N = 20), lymphocytic thyroiditis(LT) (n = 20), incidental thyroid papillary carcinoma (ITPC) (n = 20), incidental papillary carcinoma and lymphocytic thyroiditis (ITPCLT) (n = 20), and thyroid papillarycarcinoma (TPC) (n = 20). Neutrophil / lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), platelet/neutrophil ratio (PNR), lymphocyte/ monocyte ratio (LMR)and lymphocyte/ eosinophil ratio (LER) values were compared between the groups.Results: No significant difference was detected between the groups concerning the mean inflammatory cell and platelet values. However, statistical significance wasobserved between the ITPC and ITPCLT groups regarding the mean LMR and LER values (p=0.009 and p=0.037, respectively). Higher LMR was found in the ITPCgroup, while higher LER was seen in the ITPCLT group.Conclusions: We suggest that besides ratios such as NLR and PLR used as systemic inflammatory markers in carcinogenetic processes, the evaluation of LER and LMRmight be imperative as well. Therefore, these potential markers should be studied in bigger series of tumors, especially where inflammatory processes are involved in theetiology