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    Evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency
    (Galenos Yayincilik, 2020) Demir, Bulent; Demir, Sureyya Saridas; Karacaer, Kubra Ozkan; Pasa, Semir; Sılan, Fatma
    Objective: In most of primary ovarian insufficiency (POI) cases, etiologic factors have not been fully elucidated. Recent studies have revealed that inflammatory agents play an important role in the etiopathogenesis of POI. Therefore, the aim of this study was to investigate the role of inflammatory markers of hemogram parameters in POI. Materials and Methods: The study compared 47 healthy women and 47 women diagnosed as having POI retrospectively by scanning electronic and written recording systems. Complete blood counts, day-3 hormone profiles levels of all subjects were analyzed. The neutrophil-lymphocyte ratio (NLR), red cell distribution width (RDW), platelet ratio (RPR), platelet lymphocyte ratio (PLR), and mean platelet volume (MPV) mean platelet lymphocyte ratio (MPLR) were calculated from the complete blood count parameters. Results: White blood cell and MPV values, platelet, and lymphocyte counts were significantly higher in the POI patients (p<0.001, p=0.042, p=0.038, p=0.049, respectively), RPR was significantly lower than the control group (p=0.011), but there were no significant differences in hemoglobin, RDW, NLR, PLR, and MPLR (p=0.454, p=0.057, p=0.635, p=0.780, p=0.126, respectively). The neutrophil count of the study group was higher than in the control group (p=0.057). Bivariate correlation analyses showed no correlations between blood parameters and hormone levels. The area under the receiver operating characteristic curve for RPR in POI was 0.652, with a threshold value 0.053, sensitivity=63% and specificity=63. Conclusion: Inflammatory markers of hemogram detected higher in patients with POI then control subjects.
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    Maternal and foetal risks associated with teenage pregnancy - a comparative retrospective study in Turkey
    (Taylor & Francis Inc, 2024) Duran, Mehmet Nuri; Pek, Eren; Demir, Sureyya Saridas; Karacaer, Kubra Ozkan; Demir, Bulent
    BackgroundAdolescent pregnancy is defined as pregnancy occurring in young women between the ages of 10 and 19 years. Adolescent pregnancies, which are among the social healthcare concerns in developed and developing countries, have negative effects on maternal and infant health. Pregnancy in adolescence puts the health of both the mother and child at risk, as adolescent pregnancies have higher rates of eclampsia, systemic infection, low birth weight, and preterm delivery compared to other pregnancies. In this study, the effects of education level, smoking, and marital status on maternal and foetal outcomes in adolescent pregnancies were evaluated.MethodsThe records of a total of 960 pregnant women (480 pregnant adolescents aged 15-19 years and 480 pregnant adult women aged 20-26 years) were examined retrospectively. The demographic data of the groups and maternal and foetal outcomes of the pregnancies were compared. A logistic regression model was established as a statistical method for reducing confounding effects.ResultsUnmarried women were statistically significantly more prevalent in the adolescent group (38.3% vs. 7.3%). Among the considered risk factors, preeclampsia (2.9% vs. 0.8%) and smoking (29.8% vs. 9.8%) were statistically significantly more common in the adolescent group. When the groups were compared in terms of risk factors in pregnancy, it was found that pregnancy in adolescence was associated with a 3.04-fold higher risk of smoking, 5.25-fold higher risk of being unmarried, 3.50-fold higher risk of preeclampsia, and 1.70-fold higher risk of intrauterine growth retardation (IUGR).ConclusionsThis study demonstrates an increased risk of preeclampsia, IUGR, and smoking during pregnancy in adolescent pregnant women. These findings can be used to identify adolescent pregnancies requiring specific assistance and to take measures to reduce the probability of adverse outcomes. In this study, we examine the risks of adolescent pregnancies. Adolescent pregnancy is a public health problem, and it is more common in underdeveloped or developing countries. We believe that non-governmental organisations and governments should take precautions regarding adolescent pregnancies and protect this legally vulnerable sociodemographic group from pregnancy. For healthier and more conscientious pregnancy experiences, mothers must be of appropriate age, having passed the period of adolescence. Adolescent pregnancies, which come with many risks, and especially risks of preeclampsia, premature birth, and maternal death, should be minimised or prevented.
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    Öğe
    The association of oxidative stress with serum irisin and betatrophin in pregnant women with gestational diabetes mellitus
    (Via Medica, 2020) Beyazit, Fatma; Karacaer, Kubra Ozkan; Turkon, Hakan
    Background. Irisin and betatrophin are polypeptide hormones implicated in glucose metabolism and insulin resistance (IR). Gestational diabetes mellitus (GDM) is accompanied by oxidative stress (OS) and the association between circulating irisin and betatrophin levels and GDM is controversial. The present study aimed to investigate the association of second-trimester irisin, betatrophin concentrations and their correlations between serum OS markers in GDM patients. Methods. The study included 45 GDM patients and 45-age matched pregnant women as controls. Serum fasting glucose, HOMA-IR, ischemia modified albumin (IMA), total oxidative stress (TOS), total antioxidant status (TAS), oxidative stress index (OSI), irisin and betatrophin were measured. Results. Serum irisin levels were decreased and TOS and OSI levels were found to be increased in the patient group. No significant difference was found with respect to serum betatrophin and IMA levels between study groups. A correlation analysis revealed no correlation between serum irisin and other assessed variables. Conclusions. Gestational diabetes mellitus is an OS condition in addition to being a metabolic disease. Although not correlated with OS, irisin but not betatrophin may be a useful biomarker to predict GDM.