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    ANTI-APOPTOTIC AND PROLIFERATIVE EFFECT OF MODERATE EXERCISE ON TESTICULAR TISSUE IN STREPTOZOTOCIN-INDUCED RATS
    (Parlar Scientific Publications (P S P), 2022) Ozturk, Samil; Ozdemir, Ilhan; Kamalak, Zeynep; Irkin, Latife Ceyda
    DM causes damage in many tissues and organs including the reproductive system. Severe damage in the male reproductive system is an important complication of DM. The aim of this study was to examine the effects of moderate exercise on testicular tissue in streptozotocin-diabetic (STZ) rats and to investigate the possible positive effects of exercise on the histological findings. Thirty adult rats were assigned to three groups: (a) control, (b) diabetes (40 mg/kg STZ) and (c) diabetes moderate exercise. The moderate exercise group started the exercise program 3 days before the induction of diabetes. After four weeks, the testes tissues of the rats were resected. Histochemical staining of the collected tissue specimens and morphometric tests were performed. Our study showed a reduction in the testis weight in the diabetes groups. The testis tissue of the control group was normal. Despite the atrophic changes, primary spermatocytes and spermatids were available in the testis tubules of the diabetic group. In the moderate exercise group, the architecture of the seminiferous tubules was close to normal in most of the specimens and the microscopic findings were not significantly different from those of the control group. Immunohistochemical results revealed that PCNA and TUNEL positive cells were significantly increased in the diabetic groups compared to the control group (p<0.001). The findings of our study supported that exercise had a significantly favorable effect on infertility, which is a complication of diabetes. Further molecular studies are required on this subject.
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    Apoptotic effect of thymoquinone on OVCAR3 cells via the P53 and CASP3 activation
    (Acta Cirurgica Brasileira, 2024) Karaosmanoglu, Ozge; Kamalak, Zeynep; Ozdemir, Ilhan; Tuncer, Mehmet Cudi; Ozturk, Tamil
    Purpose: The limitations in cancer treatment and the inadequacy of classical methods have made it necessary to discover therapeutics in cancer treatment. The cytotoxicity of thymoquinone, which has quite different properties in terms of biological activities, in ovarian cancer cells, and the changes in the expression levels of apoptotic genes (p53/caspase-3 (casp-3)) were investigated. Methods: In the study, thymoquinone (5, 50, 100, 250 and 500 mu M and 24, 48, 72 hours) were applied to ovarian adenocarcinoma cancer cell line (OVCAR3), at different concentrations. Cytotoxic effect of thymoquinone on OVCAR-3 cells were analyzed by MTT method, and apoptotic and pro-apoptotic gene expression levels (p53, Casp-3) of thymoquinone in cancer cells were analyzed by quantitative real-time polymerase chain reaction. Results: Thymoquinone, whose effect has been revealed in many types of cancer, was shown to significantly reduce the viability of OVCAR3 cancer cells depending on the dose and time (p < 0.05). It was also determined that Casp-3 and p53 gene expressions increased in OVCAR3 cells. Conclusion: Considering the in-vitro cytotoxic activity and apoptotic gene expressions of thymoquinone, an important treatment agent, since it is a promising agent for the future of cancer treatment, more comprehensive studies may pave the way for its clinical use.
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    The Effect of Body Mass Index on Acne, Hirsutism and Menstrual Irregularity Symptoms in Turkish Adolescent Girls
    (Gazi Univ, Fac Med, 2013) Hizli, Deniz; Kosger, Hatice; Hacivelioglu, Servet; Kosus, Nermin; Kosus, Aydin; Kamalak, Zeynep; Akcal, Banu
    Purpose: The aim of the present study was to determine whether body mass index (BMI) influences polycystic ovary syndrome (PCOS) related symptoms such as acne, hirsutism and menstrual irregularity in a large healthy adolescent population. Methods: Self-administered questionnaires were distributed to all volunteer female students at 15 different secondary schools. The subjects' BMI, birthweight, age at menarche, pattern of menstrual cycle and presence of acne or hirsutism complaints were recorded. Subjects with BMI of = 18.4 kg/m 2, 18.5-24.9 kg/m(2), 25-29.9 kg/m(2) and > 30 kg/m(2) were defined as group 1, group 2, group 3 and group 4, respectively. The relation between BMI and the symptoms of acne, hirsutism and menstrual irregularity was analyzed. Results: A total of 1309 students filled the questionnaires properly and included in the study. Of these students, 314 were in group 1, 899 in group 2, 81 in group 3 and 15 in group 4. The median ages of participants were 16 years (range 13-20 years) and median age at menarche was 13 years (range of 11-16 years). A total of 106 (8.1%) participants reported various menstrual irregularity. Underweighed girls had significantly less acne (p= 0.001) and hirsutism problems (p<0.001) compared to normo weighed girls. Hirsutism incidence was significantly higher in overweighed girls than in normo weighed subjects (p<0.001). Conclusion: The present study provided the prevalence of PCOS related symptoms in population, including menstrual irregularity, acne and hirsutism according to BMI in a large adolescent population. Our results showed that menstrual irregularity was not significantly increased as BMI increased, however acne and hirsutism problems were significantly increased as BMI increased.
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    Türk adölesan kızlarda vücut kitle indeksinin akne, hirsutism ve menstrüel düzensizlik semptomları üzerine etkisi
    (2013) Hızlı, Deniz; Köşger, Hatice; Hacıvelioğlu, Servet Özden; Köşüş, Nermin; Köşüş, Aydın; Kamalak, Zeynep; Akçal, Banu Uslu
    Amaç: Bu çalışmanın amacı sağlıklı adölesan popülasyonda vücut kitleindeksinin (VKİ) polikistik over sendromların (PKOS)dan olan akne, hirsutismve menstrüel düzensizlik semptomları üzerindeki etkilerini incelemektir.Materyal ve metod: On beş farklı ortaöğretim okulunda okuyan gönüllü kızöğrencilere anket soruları dağıtıldı. Öğrencilerin VKİ, doğum ağırlığı, menarşyaşı, menstruel düzeni ve akne ve hirsutism şikayetlerinin varlığı kaydedildi.Olgular VKİe göre Grup 1; ?18.4 kg/m2, Grup 2; 18.5-24.9 kg/m2, Grup 3; 25-29.9 kg/m2 ve Grup 4; >30 kg/m2 şeklinde gruplandırıldı. VKİ ile akne,hirsutism ve menstruel düzensizlik semptomları arasındaki ilişki incelendi.Bulgular: Toplam 1309 öğrenci anketi tam doldurdu ve çalışmaya dahil edildi.Bu öğrencilerden 314ü Grup 1de, 899u Grup 2de, 81i Grup 3de, 15I Grup4de idi. Öğrencilerin ortanca yaşı 16 yıl (13-20 yıl) ve ortanca menarş yaşı 13 ıl (11-16 yıl) idi. Toplam 106 (% 8,1) öğrenci menstrual düzensizlik tarifledi.Düşük kilolu kızlar normal kilolu kızlara gore anlamlı olarak daha az akne(p=0,001) ve hirsutism (p<0,001) problemlerine sahipti. Hirsutism insidansı,kilolu kızlarda normal kilolu kızlara gore daha yüksekti (p<0,001).Sonuç: Bu çalışmada, geniş Türk adolesan populasyonda, VKİe göre PKOSunsemptomları olan akne, hirsutism ve menstruel düzensizlik prevalansı vearalarındaki ilişki araştırılmıştır. Sonuçlarımız, VKİ arttıkça menstrueldüzensizliğin anlamlı olarak artmadığını ancak akne ve hirsutismproblemlerinin anlamlı olarak arttığını göstermiştir.