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Öğe Deneysel diyabet oluşturulmuş sıçanlarda kefir'in böbrek fonksiyonlarına etkileri(Çanakkale Onsekiz Mart Üniversitesi, 2014) Kahraman, Mustafa; Deniz, MustafaBu çalışma, deneysel diyabet oluşturulan sıçanların böbrek dokusunda oluşabilecek oksidatif hasar, histolojik değişiklikler, biyokimyasal değişiklikler ve bu değişikliklere kefirin koruyucu etkisinin olup olmayacağını ortaya konulmak amacıyla planlandı. Çalışmada 40 adet sıçan kullanıldı. Diyabet oluşturmak için SF tedavili diyabet ve kefir tedavili diyabet gruplarındaki sıçanlara 65 mg/kg tek doz streptozotosin, intraperitoneal uygulandı. Kontrol grubu ve SF tedavili diyabet grubuna aynı miktarda serum fizyolojik enjekte edildi. Kan glukozları 250 mg/dl ve üzerinde olanlar diyabetik olarak kabul edilip çalışmaya dahil edildi. Kontrol kefir ve kefir tedavili diyabet gruplarındaki sıçanlara kefir, 10 ml/kg/gün olarak 35 gün boyunca verildi. Çalışma 1. gününde sıçanların kan glukozlarına bakıldı. Çalışmanın 36. gününde sıçanlar dekapite edilerek kanda glukoz, üre, kreatinin, sodyum, potasyum ve klor idrarda glukoz, kreatinin, mikroalbuminüri ve sodyum parametrelerine bakıldı. 24 saatlik idrar hacimleri ölçüldü. Kan ve idrar testlerinin sonuçlarıyla fraksiyonel sodyum ekskresyonu, fraksiyonel su eksresyonu ve glomerüler filtrasyon hızı hesaplandı. Gruplardan alınan böbrek dokularında ise süperoksit dismutaz, katalaz, glutatyon, malondialdehit ve miyeloperoksidaz düzeyleri ölçüldü. Böbrek dokusunda histolojik inceleme yapıldı. Çalışma sonucunda biyokimyasal ve antioksidan parametrelerin analizlerinde ve histolojik değerlendirmede anlamlı sonuçlar bulundu. Diyabetin böbreklere hasar verdiği hem biyokimyasal hem de histolojik olarak tespit edildi. Kefirin, diyabetin böbrekte oluşturduğu hasarı azalttığı görüldü.Öğe Efficacy of synchronized diabetes monitoring system in patients with type 2 diabetes: Preliminary results of a pilot, randomized clinical trial(Elsevier Ltd, 2025) Kahraman, Mustafa; Mutlu, Ummu; Ozbek, Hasan Ediz; Boz, Elif Beyza; Çakmak, Ramazan; Kurt, Serkan; Dudukcu, Hatice VildanAim The purpose of this study is to evaluate the applicability and efficacy of the Synchronized Diabetes Monitoring System (SDMs), which consists of a smart cap attached to insulin pens with recording, alarm, alert, and reminder functions, and software that operates via Bluetooth, in patients with type 2 diabetes on insulin treatment. Methods The system consists of a smart mobile apparatus mounted on an insulin pen and automatically recording the dose and time of the administered insulin, an application developed for mobile phones that can read blood glucose results from the glucometer, and a website. Results The system has been tested in a 6-month pilot cohort of SDMs group (n = 23, 44 % female, age: 50.1 ± 13 years, duration: 12.2 ± 9.2 years) in a transparent, controlled, and single-center pilot trial, showing promising results. The results were compared to the control group (n = 23, age: 54 ± 9.3 years, 52 % female, duration: 13.8 ± 7.4 years). In the third month, we found that they had better glycemic control, as indicated by a decrease in fasting blood glucose (from 147 to 114 mg/dL, p = 0.024) and HbA1c levels (from 8.5 % to 7.2 %, p = 0.003). Additionally, improvements were achieved in physical function, role limitation, and physical and mental health domains of SF-36 survey in patients using the system. Conclusion The preliminary results from this pilot study suggest that the synchronized diabetes monitoring system have the potential to improve glycemic control and increase health satisfaction in insulin-treated patients with type 2 diabetes. © 2025 Primary Care Diabetes Europe.Öğe Protective Effect of Possible Olive Oil, Olive Leaves and Olive Seeds on Ethanol Induced Experimental Ulcer Model in Rats(Wiley-Blackwell, 2015) Vural, Zehra; Kahraman, Mustafa; Sehitoglu, Hilal; Vural, Ahmet; Arik, Kasim; Simsek, Tuncer; Cetiner, Sule[Anstract Not Available]Öğe The Effects of Kefir on Kidney Tissues and Functions in Diabetic Rats(Springer, 2021) Kahraman, Mustafa; Ertekin, Yusuf Haydar; Satman, İlhanThis study was designed to determine the protective effect of kefir on the oxidative damage, as well as histological and biochemical changes that occur in the kidney tissues of experimental diabetic rats. Forty rats were allocated into four groups as “healthy saline” (SF), “healthy kefir” (KF), and the same groups with experimentally induced diabetes (DSF and DKF). Diabetes was induced by administering 65 mg/kg single-dose streptozotocin. Oral kefir was given 10 ml/kg/day for 35 days to the rats in the groups KF and DKF. The same amount of saline was given to the groups SF and DSF. On the 36th day of the study, blood glucose, urea, and creatinine were measured besides glucose, creatinine, microalbuminuria, and sodium in the urine. Additionally, histological examination was performed on the kidney tissues. Blood glucose, creatinine, and urea levels were significantly lower in the DKF group compared with those of the DSF group (p < 0.001). Also, the creatinine level was significantly decreased (p < 0.001), and microalbuminuria was increased (p < 0.001) in the DKF group compared with that of the DSF group. Histologically, intermittent expansion in the renal glomeruli, reduction of cast formation in the tubules, and improvement in the renal epithelial tissues of the DKF group were observed. Kefir decreased the damage caused by diabetes. These results indicate that kefir supplementation may contribute to better control of oxidative stress, which is related to the improvement of renal functions, suggesting its use to slow down the progression of diabetic nephropathy.Öğe The Effects of Kefir on the Renal Functions of Rats with Streptozotosin Induced Experimental Diabetes Mellitus(Wiley-Blackwell, 2015) Kahraman, Mustafa; Ertekin, Yusuf Haydar; Turkon, Hakan; Cetinel, Sule; Arik, Muhammet Kasim; Deniz, Mustafa[Anstract Not Available]
