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Öğe A Case of Sporadic Creutzfeldt-Jakob Disease That Developed With Psychiatric Symptoms(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2015) Ozkan, Adile; Aydin Canturk, Ilknur; Candan, Fatma; Isik, Nihal; Ozisik Karaman, Handan IsinCreutzfeldt-Jakob disease (CJD) is a fairly rare prion sickness characterized by rapidly progressive dementia and neuropsychiatric symptoms. The diversity of clinical characteristics of the disease causes difficulties during diagnosis. The first finding of the disease might be psychiatric symptoms. The male patient who was diagnosed with CJD after dementia, ataxia, and myoclonus developed rapidly following psychiatric symptoms, was presented in order to draw attention to the onset with psychiatric symptoms in CJD.Öğe Early and Late Onset Seizures After Cerebrovascular Disease(Kare Publ, 2015) Ozkan, Adile; Gokceer, Sevda Yildiz; Isik, Nihal; Canturk, Ilknur Aydin; Candan, FatmaObjectives: This study aimed to compare seizure types, clinical and demographic features, treatment response and prognosis among patients with early and late onset post-stroke seizures. Methods: A retrospective evaluation was made of the data of 46 patients admitted to our clinic between January 2000 and April 2006 diagnosed with cerebrovascular disease, and who had post-stroke epileptic seizures. Two types of post-stroke seizures were defined; 'early onset' (occurring within 14 days post-stroke) and ` late onset' (occurring after the 14th day). Results: Among the 46 patients, 15 (32.6%) had early onset and 31 (67.3%) had late onset seizures. The early onset post-stroke seizures occurred more frequently after hemorrhagic stroke, while the late onset were more often seen in ischemic stroke. Ischemic strokes occurred mostly in the middle cerebral artery area, whereas lobar cortical hematomas were observed in the hemorrhagic stroke patients. The early onset seizures had statistically significant left hemisphere lesions, while those which were late onset had right hemisphere lesions (p<0.038). Secondary generalized seizures were the most common type in both groups. The seizures were well controlled with monotherapy in both groups, but seizure recurrence was found to be higher in the late onset seizure group. Conclusion: This study found significant left hemisphere lesions in the patients with early onset seizures, while in those with late onset seizures, lesions were present in the right hemisphere. In both groups, cortical involvement played an important role. Secondary generalized seizures were the most frequently occurring, and these were treated with antiepileptic monotherapy.Öğe Evaluation of the Thalamic Region with Proton Magnetic Resonance Spectroscopy in Patients with Essential Tremor(Turkish Neurological Soc, 2015) Ozkan, Adile; Candan, Fatma; Isik, Nihal; Canturk, Ilknur Aydin; Ari, Semra; Cakmak, Ozgur Oztop; Ayaz, TunahanObjective: Although essential tremor (ET) is the most common movement disorder, its pathogenesis is poorly understood. It is suggested that the ventral intermediate (VIM) nucleus of the thalamus is important in the pathophysiology disease. Materials and Methods: The present study aimed to evaluate N-acetylaspartate (NAA), choline (cho), and creatinine (Cr) values via proton magnetic resonance spectroscopy (H-1 MRS) of the VIM of the thalamus in 16 control patients and 42 patients with ET. Results: The mean NAA/Cr and NAA/Cho values of the thalamus VIM nucleus region in patients with ET was statistically significantly lower than the control group (p=0.001, p=0.005, respectively). In patients with ET, no significant relation was found between NAA/Cr, NAA/Cho values, and age, family history, disease duration, tremor severity, dominant extremity localization of tremor, and history of drug use (p>0.05). Conclusion: Low NAA values in the thalamus region of patients with ET indicate neuron loss and cell death. Neuron loss in the thalamus region has been suggested to play a part in the pathophysiology of the disease, and may indicate that ET is a neurodegenerative disease.Öğe Experiences in an Epilepsy Polyclinic: Epilepsy in the Elderly(Kare Publ, 2015) Ozkan, Adile; Candan, Fatma; Canturk, Ilknur Aydin; Gokceer, Sevda Yildiz; Isik, Nihal; Karaman, Handan Isin OzisikObjectives: Epilepsy is one of the most common serious neurological disorders in the elderly. In this study the demographic and clinical features, etiological factors, seizure types and response ratios to treatment are presented for a group of patients aged 60 years and over diagnosed with epilepsy. Results: Twenty-five patients aged 60 years and over who applied to the epilepsy polyclinic were retrospectively investigated. Results: Average patient age was 75.0 +/- 7.1 years and average disease duration was 2.32 +/- 1.8 years. Sixteen patients were male and 9 female. Among the patients, cerebrovascular disease (17 patients), brain tumor (1 patient), arachnoid cyst (1 patient), aneurysm (1 patient) and myocardial infarction (1 patient) were considered as the underlying factors in seizure development. In the remaining 4 cases, no etiological cause was determined. Seizure types were; secondary generalized tonic-clonic seizure (20 patients), simple partial seizure (2 patients), status epilepticus seizure (2 patients), and complex partial seizure (1 patient). EEG findings were abnormal in 32% of the patients (n=8). When evaluated for treatment, 18 patients received monotherapy; 6 patients used double, and 1 patient used triple drugs. The follow-up period in 21 cases was without seizure. Conclusion: In the study, the most common etiological cause of epilepsy seen in the elderly was cerebrovascular disease. Seizure type was mainly secondary generalized tonic-clonic. The patients responded well to monotherapy and prognosis was improved.
